ID G3UHP2_LOXAF Unreviewed; 611 AA.
AC G3UHP2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=SH3 domain containing ring finger 2 {ECO:0000313|Ensembl:ENSLAFP00000027350.1};
GN Name=SH3RF2 {ECO:0000313|Ensembl:ENSLAFP00000027350.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000027350.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000027350.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027350.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000027350.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000027350.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3UHP2; -.
DR STRING; 9785.ENSLAFP00000027350; -.
DR Ensembl; ENSLAFT00000027656.1; ENSLAFP00000027350.1; ENSLAFG00000000315.3.
DR eggNOG; KOG2177; Eukaryota.
DR GeneTree; ENSGT00940000160067; -.
DR InParanoid; G3UHP2; -.
DR OMA; PRLHMEG; -.
DR TreeFam; TF105571; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0008157; F:protein phosphatase 1 binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0031397; P:negative regulation of protein ubiquitination; IEA:Ensembl.
DR GO; GO:0030335; P:positive regulation of cell migration; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0051865; P:protein autoubiquitination; IEA:Ensembl.
DR CDD; cd11929; SH3_SH3RF2_1; 1.
DR CDD; cd11932; SH3_SH3RF2_2; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035792; SH3RF2_SH3_1.
DR InterPro; IPR035794; SH3RF2_SH3_2.
DR PANTHER; PTHR14167:SF60; E3 UBIQUITIN-PROTEIN LIGASE SH3RF2; 1.
DR PANTHER; PTHR14167; SH3 DOMAIN-CONTAINING; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR PRINTS; PR00499; P67PHOX.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..58
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 61..126
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 133..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 440..469
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 488..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..530
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 611 AA; 66004 MW; 68B80DE77E3D5E82 CRC64;
VPRAKALCNY RGQNPGDLRF NKGDVILLRR QLDENWYQGE INGVSGIFPA SSVEIIKQLP
QPPPLCRALY NFDLRDRDKS ENQDCLTFLK DDIITVISRV DENWAEGKLG DKVGIFPILF
VEPNLTARHL LEKNKGRPSS RTKNLPLGPS SPRGKAINSP VLRRGPGSRR KLPGQFSITT
ALNTLNRMVH SPSGRHMVEI STPVLISSSN PSVITQHMEK ADIPPSSVGQ ERASSKHPGP
TKPGGRESTA LIILPAPAHH HGVLRAFAVH SSKKGETERA DSRRGEQVGV GSEIWCGWGR
GTANLPGRAS IFCPSSYLKI PTTRKTSSFP ESRSPGLYAT WTLSTSSVSS QGSISEGDPR
QSRPFKSVFV PTAIVNPVRS STASPGTVAQ GSLRKGRSSM RKNGSLQRPV QSGIPTLVVG
SLRRSPTMVV QPQQFQFYQP QGVPSSPSSV AVEMGPKPAP TGEPALTCVS RGNDTRIHSA
ASSLIMEGKE NPIKSEPPLK PPASAPPSIL VKPENSRNGT EKQVKTVRFQ NYSPPPAKHY
TYGKPEQPAT PKGSQPEAAP LGPEMTILFA HRSGCHSGQQ TDLRRKPTFG KAMSPVPVPT
ASATQTVFPS K
//
