ID G3UKK8_LOXAF Unreviewed; 710 AA.
AC G3UKK8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Proprotein convertase subtilisin/kexin type 5 {ECO:0000313|Ensembl:ENSLAFP00000028367.1};
GN Name=PCSK5 {ECO:0000313|Ensembl:ENSLAFP00000028367.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028367.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028367.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028367.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028367.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028367.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase S8 family.
CC {ECO:0000256|ARBA:ARBA00011073, ECO:0000256|PROSITE-ProRule:PRU01240}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU01240}.
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DR AlphaFoldDB; G3UKK8; -.
DR MEROPS; S08.076; -.
DR Ensembl; ENSLAFT00000034838.1; ENSLAFP00000028367.1; ENSLAFG00000015309.3.
DR GeneTree; ENSGT00940000155770; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00064; FU; 5.
DR CDD; cd04059; Peptidases_S8_Protein_convertases_Kexins_Furin-like; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR034182; Kexin/furin.
DR InterPro; IPR002884; P_dom.
DR InterPro; IPR000209; Peptidase_S8/S53_dom.
DR InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR InterPro; IPR022398; Peptidase_S8_His-AS.
DR InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR InterPro; IPR010909; PLAC.
DR PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR PANTHER; PTHR42884:SF7; PROPROTEIN CONVERTASE SUBTILISIN_KEXIN TYPE 5; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF01483; P_proprotein; 1.
DR Pfam; PF00082; Peptidase_S8; 1.
DR Pfam; PF08686; PLAC; 1.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00261; FU; 5.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52743; Subtilisin-like; 1.
DR PROSITE; PS51829; P_HOMO_B; 1.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS51892; SUBTILASE; 1.
DR PROSITE; PS00137; SUBTILASE_HIS; 1.
DR PROSITE; PS00138; SUBTILASE_SER; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Serine protease {ECO:0000256|ARBA:ARBA00022825};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 251..391
FT /note="P/Homo B"
FT /evidence="ECO:0000259|PROSITE:PS51829"
FT DOMAIN 672..710
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
SQ SEQUENCE 710 AA; 78411 MW; 208530EDF4A30501 CRC64;
RHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA
SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI
YTISISSTAE SGKKPWYLEE CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP
MAAGIIALAL EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE
AMVMEAEKWT TVPQQHVCVE STDRQIKTIR PNSAVRSIYK ASGCSDNPNH HVNYLEHVVV
RITITHPRRG DLAIYLTSPS GTRSQLLANR LFDHSMEGFK NWEFMTIHCW GERAAGDWIL
EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV QPYSPTNEFP KVERVRYSRV EDPTDDYGTE
DYAGQITPAN NQEYIPSSCD PECSEVGCDG PGPDHCNDCL HYYYKLKNNT RICVSSCPPG
HYHADKKRCR KCAPNCESCF GSHSDQCLSC KYGYFLNEDI NSCVTHCPEG FYQDTKKNLC
RKCSENCKTC TESLNCTECR DGLSLQGSRC SVTCEDGWYF DGQDCQPCHR FCATCAGAGA
DGCINCTEGY FMEDGRCVQS CSISYYFDYP SENGYKSCKK CDASCLTCNG PGFKNCTSCP
SGYLLDLGMC QMGAICKDGD YTLCAVVKKN NLCQRKVLQQ LCCKTCTFQG
//
