ID G3UKM0_LOXAF Unreviewed; 956 AA.
AC G3UKM0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=HECT and RLD domain containing E3 ubiquitin protein ligase 5 {ECO:0000313|Ensembl:ENSLAFP00000028379.1};
GN Name=HERC5 {ECO:0000313|Ensembl:ENSLAFP00000028379.1};
OS Loxodonta africana (African elephant).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028379.1, ECO:0000313|Proteomes:UP000007646};
RN [1] {ECO:0000313|Ensembl:ENSLAFP00000028379.1, ECO:0000313|Proteomes:UP000007646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028379.1,
RC ECO:0000313|Proteomes:UP000007646};
RA Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Loxodonta africana (African elephant).";
RL Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSLAFP00000028379.1}
RP IDENTIFICATION.
RC STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028379.1};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR Ensembl; ENSLAFT00000037128.1; ENSLAFP00000028379.1; ENSLAFG00000011856.3.
DR GeneTree; ENSGT00940000162703; -.
DR HOGENOM; CLU_002173_5_3_1; -.
DR Proteomes; UP000007646; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR PANTHER; PTHR45622:SF7; E3 ISG15--PROTEIN LIGASE HERC5; 1.
DR PANTHER; PTHR45622; UBIQUITIN-PROTEIN LIGASE E3A-RELATED; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF00415; RCC1; 3.
DR Pfam; PF13540; RCC1_2; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT REPEAT 164..216
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 217..268
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 269..320
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 322..384
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 633..956
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 926
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 956 AA; 107903 MW; FE81E4E0E924721D CRC64;
MKRMPRRRSR GPERPAPKPK PASRPGARSS AAFSDPRGAQ LWLFPSSAGL SQALSGRCKK
TRQICCTQDR LAVLEHGGAR VEVHQLPVGS HSAGKPKYMT LERKMMIHSI DQGAEHMLIL
SSDGKPFEYN YGIEPARFQC VLRQKIIIQI ACGDYHSLAL SKGGELFAWG QNLHGQLGVG
RIVDSTPTPQ IVAHLSGVPL AQISAGEAHS MALSMSGNVY SWGKNDFGQL GLGHTDSKDS
PSLIEELDNQ DVEFLTCGGS HTALLTKDGL VFTFGAGQYG QLGHNSAQNE PRPRLVTELV
GNRVTQIACG RDHTLAYVSD LGKVFSFGSG KEGQLGNGGT HNQLIPLPMK LPSQEELKFE
NCTSKKELIM IAGGNQSILL WMGKENSYVN LKRKPTLKEG TVERWIADVG TKQWHSTQRE
IREIFSSPAC LTGSFLKKRI PAETMSISLD LNKARDTFKE LTQNAWIANT ITTCLRDNLL
VNLPLHPPHQ EALEVFLLLP ECPVMQDSNN WKSLMVPFAK AVCKISDQSS GILENYWASL
EESTFSKLVQ VLKGAIVSLM DYWTESHENH CHMQVLLKML KKLHRVKKFI AFMPLSETEA
VGESKSPLEP NFNLTVRRSH LVEDVFNQLH QSEIEDLRKE LWVSFSGEIN YGFGGVRLEF
FHCIFEEMTR PEYGMFMYPE EASYMWFPVR PKFEEKRYFF FGVLCGLSLF NFSVANIPFP
LALFKKLLDQ TPSLEDLKEL SPVLGKCLQT LLDDEGKDFG EVFYIRFDAH WDKNEAELIP
NGSDIMVDQT NKREYVSKYV DYIFNVSVKG VYEEFQRGFY SVCDKELIEI FHPEELKDVI
IGNTDYDWET FEKNACYEEG YSSSHPTIEM FWKALHKLTL EEKKKFLVLP LLGXDRLQMG
GLKNMKITFC CPGNLNEKDP IRAQTCLSII YLPKYSTMER VEEALHVAID SHRGFG
//
