GenomeNet

Database: UniProt
Entry: G3UKW6_LOXAF
LinkDB: G3UKW6_LOXAF
Original site: G3UKW6_LOXAF 
ID   G3UKW6_LOXAF            Unreviewed;       327 AA.
AC   G3UKW6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   08-NOV-2023, entry version 54.
DE   RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028475.1, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000028475.1, ECO:0000313|Proteomes:UP000007646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028475.1,
RC   ECO:0000313|Proteomes:UP000007646};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000028475.1}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028475.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   AlphaFoldDB; G3UKW6; -.
DR   STRING; 9785.ENSLAFP00000028475; -.
DR   Ensembl; ENSLAFT00000028981.1; ENSLAFP00000028475.1; ENSLAFG00000002901.2.
DR   eggNOG; ENOG502QQGM; Eukaryota.
DR   GeneTree; ENSGT00990000203527; -.
DR   InParanoid; G3UKW6; -.
DR   OMA; HWLYFSV; -.
DR   TreeFam; TF350010; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0071398; P:cellular response to fatty acid; IEA:Ensembl.
DR   GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR   GO; GO:0002385; P:mucosal immune response; IEA:Ensembl.
DR   GO; GO:0045776; P:negative regulation of blood pressure; IEA:Ensembl.
DR   GO; GO:0046676; P:negative regulation of insulin secretion; IEA:Ensembl.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0002879; P:positive regulation of acute inflammatory response to non-antigenic stimulus; IEA:Ensembl.
DR   GO; GO:0032722; P:positive regulation of chemokine production; IEA:Ensembl.
DR   GO; GO:0002720; P:positive regulation of cytokine production involved in immune response; IEA:Ensembl.
DR   GO; GO:1904457; P:positive regulation of neuronal action potential; IEA:Ensembl.
DR   GO; GO:0003062; P:regulation of heart rate by chemical signal; IEA:Ensembl.
DR   GO; GO:0046885; P:regulation of hormone biosynthetic process; IEA:Ensembl.
DR   GO; GO:0046626; P:regulation of insulin receptor signaling pathway; IEA:Ensembl.
DR   CDD; cd15170; 7tmA_FFAR2_FFAR3; 1.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR013312; GPR40-rel_orph.
DR   PANTHER; PTHR45822; FREE FATTY ACID RECEPTOR 2-RELATED; 1.
DR   PANTHER; PTHR45822:SF6; FREE FATTY ACID RECEPTOR 3-RELATED; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01904; GPR40FAMILY.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        15..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        52..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        90..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        132..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        188..211
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        261..278
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          31..276
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   327 AA;  36872 MW;  D547D57246910E2B CRC64;
     MGTNPEQSFF PGHHWLYFSV YLFAFLVGLP LNLMALVIFV GKLRHRPVAV DVLLLNLTIS
     DLILLLFLPF RMVEAANGMR WPLPFFLCPF SGFLFFTTIY LTSLFLAAVS IERFLSVAYP
     VWYKTRPRPG QAVLVSGACW LLAAGHCSVV YVIELSEGSS HSPNTNGTCY LEFQEYQLAI
     LLPVRLEMAV VLFGMPLLIT SYCYSQLVWI LSKGASHHRR KRVAGLVAAT LLNFLVCFGP
     YNVSHVVGYV RGESPSWRGY VLLLSTLNSC IDPFVYYFSS SGFQADFQGL LRRLAGVWSS
     YRRERSVELK GKEGVKRGEH SLRELPS
//
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