GenomeNet

Database: UniProt
Entry: G3ULN8_LOXAF
LinkDB: G3ULN8_LOXAF
Original site: G3ULN8_LOXAF 
ID   G3ULN8_LOXAF            Unreviewed;      4470 AA.
AC   G3ULN8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSLAFP00000028747};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSLAFP00000028747};
OS   Loxodonta africana (African elephant).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta.
OX   NCBI_TaxID=9785 {ECO:0000313|Ensembl:ENSLAFP00000028747, ECO:0000313|Proteomes:UP000007646};
RN   [1] {ECO:0000313|Ensembl:ENSLAFP00000028747}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028747};
RA   Di Palma F., Heiman D., Young S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "The Genome Sequence of Loxodonta africana (African elephant).";
RL   Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSLAFP00000028747}
RP   IDENTIFICATION.
RC   STRAIN=Isolate ISIS603380 {ECO:0000313|Ensembl:ENSLAFP00000028747};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSLAFP00000028747}.
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DR   STRING; 9785.ENSLAFP00000028747; -.
DR   Ensembl; ENSLAFT00000027003; ENSLAFP00000028747; ENSLAFG00000005626.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3ULN8; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007646; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 8.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3776   3800       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4011   4031       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4079   4098       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4210   4228       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4271   4292       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4351   4374       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       61    272       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      488    684       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      824   1040       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3512   3547       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4470 AA;  507715 MW;  90DD7C19562B3BAD CRC64;
     AALIRGNRNN CAQFSNNLDW LISKLDRLES SSGILEVLHC ILIESPEALN LIAEGHIKSI
     ISLLDKHGRN HKVLDVLCSL CLCNGVAVRA NQNLICDNLL PRRNLLLQTR LINDVTSIRP
     NIFLGVAEGS AQYKKWYFEL IIDQVDPFLT AEPTHLRVGW ASSSGYAPYP GGGEGWGGNG
     VGDDLYSYGF DGLHLWSGRI PRAVASINQH LLRSDDVVSC CLDLGVPSIS FRINGQPVQG
     MFENFNTDGL FFPVVSFSAG VKVRFLMGGR HGEFKFLPPS GYAPCYEALL PKEKMRLEPV
     KEYKRDAEGV RDLLGTTQFL SQASFIPCPI DTSQVVLPPH LEKIRDRLAE NIHELWGMNK
     IELGWTFGKT RDDNKRQHPC LVEFSKLPET EKNYNLQMST ETLKTLLALG CHIAHANPAA
     EEDLKKVKLP KNYMMSNGYK PAPLDLSDVK LSPPQEILVD KLAENAHNVW AKDRLKQGWT
     YGIQQDLKNK RNPRLVPYAL LDERTKKSNR DSLREAVRTF VGYGYNIEPS DQELADPTVE
     KVSIDKIRFF RVERSYAVRS GKWYFEFEVV TGGDMRVGWA RPGCRPDIEL GADDQAFVFE
     GSRGQRWHQG SGYFGRTWQP GDVVGCMINL DDASMIFTLN GELLITNKGS ELAFADYEVE
     NGFVPICSLG LSQIGRMNLG TDASTFKYYT MCGLQEGFEP FAVNMNRDVA MWFSKRLPTF
     VNVPKDHPHI EVMRIDGTMD SPPCLKVSHK TFGTQNSSAG MIYCRLSMPV ECHSSFSHIP
     CLDSDAFQKS SHANHEACEV FLPDTDYILC CPLMHSWLGK QNNLFIGIPT YIFTLSPHPP
     TLICHLRSVV CQNCGFFIKM TNLNMDYSPP RKQILPWVRS SVSPHSARNN VETVIITCQC
     YYAIRIFAGQ DPTCVWVGWV TPDYHLYSEK FDLNKNCTVT VTLGDERGRV HESLSVKRSN
     CYMVWGGDIV ASSQRSSRSN VDLEIGCLVD LAMGMLSFSA NGKELGTCYQ VEPNTKVFPA
     VFLQPTSTSL FQFELGKLKN AMPLSAAIFK SEEKNPVPQC PPRLDVQTIQ PVLWSRMPSN
     FLKVEMERVS ERHGWVVQCL EPLQMMALYI PEENRCVDIL ELCEQEDLMQ FHYHTLRLYS
     AVCALGNNRV AYALCSHVDL SQLFYAIDNK YLPGLLRSGF YDLLISIHLA NAKERKLMMK
     NEYIIPITST TRKVSLYPDE SKRHGLPGVG LRTCLKPGFR FSTPCFVVTS EEHHKQSPEI
     PLEILKTKAL SMLTEAVQCS GAHIRDPVGG SVEFQFVPVL KLIGSLLVMG VFNDEDVQQI
     LLLIDPSVFG EHSGETEEGG EKEEVTQVEE KAVEAGEKAS KEAQAPVKGL LQTRIPESVK
     LQMCELLSYL CDCELQHRVE AIVAFGDIYV SKLQANQKFR YNELMQALNM SAALTARKTK
     EFRSPPQEQI NMLVNFQLGE NCPCPEEIRE ELYDFHEDLL LHCGVPLEEE EEEEDNTSWT
     GKLWSLVYKI KGLPKPEKQQ PTEEEEGAPM QHRPSYTTLK ELISQTMICW AQEDQVQDAE
     LVRMMFTLLR RQYDSIGELL QALRKTYTIS HASVSDTINL LAALGQIRSL LSVRMGKEEE
     LLMIHGLGDI MNNKVFYQHP NLMRVLGMHE TVMEVMVNVL GTEKSQIAFP KMVASCCRFL
     CYFCRISRQN QKAMFEHLSY LLENSSFGLA SPSMRGSTPL DVAASSVMDN NELALSLEEP
     DLEKVVTYLA GCGLQSCPML LAKGYPDIGW NPIEGERYLS FLRFAVFVNS ESVEENASVV
     VKLLIRRPEC FGPALRGEGG NGLLAAMQGA IKISENPALD LPSQGYKREV SMEDDGEGEE
     IVHMGNAIMS FYSALIDLLG RCAPEMHLIQ TGKGEAIRIR SILRSLVPTE DLVGIISIPL
     KLPSVNKDGS VMEPDMAANF CPDHKAPMVL FMDRVYGIKD QPFLLHLLEV GFLPDLRASA
     SLDTVSLSTT EAALALNRYI CSAVLPLLTR CAPLFAGTEH CTSLIDSTLQ TIYRLSKGRS
     LTKAQRDTIE ECLLAICNHL RPSMLQQLLR RLVFDVPLLN EYCKMPLKLL TNHYEQCWKY
     YCLPSGWGSY GLAVEEELHL TEKLFWGIFD SLSHKKYDPD LFRMALPCLS AIAGALPPDY
     LDTRITATLE KQVSVDAEGN FDPKPINTMN FSLPEKLEYV VTKYAEHSHD KWACDKSQNG
     WKYGISLDEN VKTHPLIRPF RTLTEKEKEI YRWPARESLK TMLAVGWTVE RTKEGEALVQ
     QRENEKLRSM SQASQVQQPS QSYSPAPLDL SNVVLSRELQ GMVEVVAENY HNIWAKKKKL
     ELESKGGGSH PLLVPYDTLT AKEKFRDREK AQDLFKFLQV NGIIVSRGMK DMELDASSME
     KRFAHKFLKK ILKYVDSAQE FIAHLEAIVS SGKTEKSPHD QEIKFFAKVL LPLVDQYFTN
     HRLYFLSSPL KPLSSSGYAS HKEKEMVASL FCKLAALVRH RISLFGSDST TMVSCLHILA
     QTLDTRTVMK SGSELVKAGL RAFFENAAED LEKTSENLKL GKFTHSRTQI KGVSQNINYT
     TVALLPILTS IFEHVAQHQF GMDLLLGDVQ ISCYHTLCSL YSLGTGKNIY VERQRPALGE
     CLASLAATIP VAFLEPTLNR NNPLSVFNTK TPRERSILGM PDTVEEMCPD IPHLEGLMKE
     INDLAESGAR YTEMPHVIEV ILPMLCNYLS YWWERGPENL PPSAGPCCTQ VTSEHLSVIL
     GNILKIINNN LGIDEASWMK RIAVYAQPII SKARPDLLRS HFIPTLEKLK KKAVKIVQEE
     EQLKADSRGD TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRSNWLKS PGADSDQLFR
     MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDSKS KMSKAMQVKS GGQDQERKKT
     KRRGDFYSIQ TSLIVAALKK MLPIGLNMCT PGDQELISLA KSRYSYRDTD EEVKEHLRNN
     LHLQEKVRND PAVKWQLNLY KDVLKSEEPS NPEKTVERVQ RISAAVFHLE QVEQPLRSKK
     AVWHKLLSKQ RKRAVVACFR MAPLYNLPRH RSINLFLHGY QRFWIETEEY SFEEKLVQDL
     AKSPKAEEEE EEEMEKPPDP LHQIILHFSR NALTERSKLE DDPLYTSYSS MMAKSCQNGE
     DEEEEDKEKT FEEKEMEKQK TLYQQARLHE RGAAEMVLQM ISASKGEMSP MVVETLKLGI
     AILNGGNTSV QQKMLDYLKE KKDAGFFQSL SGLMQSCSLL KSVLDLNAFE RQNKAEGLGM
     VTEEGTRPVI VRERGEKVLQ NDEFTRDLFR FLQLLCEGHN SDFQNFLRTQ MGNTTTVNII
     ISTVDYLLRL QESISDFYWY YSGKDIIDES GQHNFSKALA VTKQIFNSLT EYIQGPCIGN
     QQSLAHSRLW DAVVGFLHVF ANMQMKLSQD SSQIELLKEL LDLLQDMVVM LLSLLEGNVV
     NGTIGKQMVD TLVESSTNVE MILKFFDMFL KLKDLTSSET FKEYDPDGKG IISKKEFQKA
     MEGQKQYTQS EIDFLLSCAE ADENDMFNYI DFVDRFHEPA KDIGFNVAVL LTNLSEHMPN
     DSRLKCLLDP AESVLNYFEP YLGRIEIMGG AKKIERVYFE ISESSRTQWE KPQVKESKRQ
     FIFDVVNEGG EQEKMELFVN FCEDTIFEMQ LASQISESDS ADRPEEVEEE EDSLYTLEME
     GDEEEDTSFE TASAFAMACA SVKRNIANFL KRATLKNLKK QYRKVKKMTA KELVKVFFSF
     FWMLFVGLFQ LFFTILGGVF QILWNTVFGG GLVEGAKNIR VTKILGDMPD PTQFGIHDDV
     IEAERAEVIE PGITTELVHF IKGEKGDADI MSDLFGLHPK KEGSLKHGPD GGLGDLSEII
     GKDGPPTLES TVQKKRKAQV CLVNGKHRKP NPPVSSPPEW VSRPCSMEDG EKEERAKEEE
     QAEYLWAEVT KKKKRRRGQK VEKPEAFMAN FFKRLEIYQT KLLHYLARNF YNLRFLALFV
     AFAINFILLF YKVTEEPLEE ETEDVANLWN SFNDEEEEEA MVFFVLQEST GYMAPTLRAL
     AIIHTIISLV CVVGYYCLKV PLVVFKREKE IARKLEFDGL YITEQPSEDD IKGQWDRLVI
     NTPSFPSNYW DKFVKRKVIN KYGDLYGAER IAELLGLDKN ALDFSPVEEA KTEEASLVSW
     LSSVDMKYHI WKLGVVFTDN SFLYLAWYTT MSFLGHYNNF FFAAHLLDIA MGFKTLRTIL
     SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE DDDEPDMKCD DMMTCYLFHM
     YVGVRAGGGI GDEIEDPAGD PYEMYRIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ
     EQVREDMETK CFICGIGNDY FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE
     SYVWKMYQER CWDFFPAGDC FRKQYEDQLG
//
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