GenomeNet

Database: UniProt
Entry: G3USD2_MELGA
LinkDB: G3USD2_MELGA
Original site: G3USD2_MELGA 
ID   G3USD2_MELGA            Unreviewed;       462 AA.
AC   G3USD2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   24-JAN-2024, entry version 58.
DE   RecName: Full=renin {ECO:0000256|ARBA:ARBA00013216};
DE            EC=3.4.23.15 {ECO:0000256|ARBA:ARBA00013216};
DE   AltName: Full=Angiotensinogenase {ECO:0000256|ARBA:ARBA00032220};
GN   Name=REN {ECO:0000313|Ensembl:ENSMGAP00000018605.2};
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000018605.2, ECO:0000313|Proteomes:UP000001645};
RN   [1] {ECO:0000313|Ensembl:ENSMGAP00000018605.2, ECO:0000313|Proteomes:UP000001645}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA   Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA   Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA   Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA   Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA   Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA   Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA   Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA   Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA   Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA   Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA   Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA   Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA   Zhang Y., Reed K.M.;
RT   "Multi-platform next-generation sequencing of the domestic turkey
RT   (Meleagris gallopavo): genome assembly and analysis.";
RL   PLoS Biol. 8:E1000475-E1000475(2010).
RN   [2] {ECO:0000313|Ensembl:ENSMGAP00000018605.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Cleavage of Leu-|-Xaa bond in angiotensinogen to generate
CC         angiotensin I.; EC=3.4.23.15;
CC         Evidence={ECO:0000256|ARBA:ARBA00000430};
CC   -!- SIMILARITY: Belongs to the peptidase A1 family.
CC       {ECO:0000256|ARBA:ARBA00007447, ECO:0000256|RuleBase:RU000454}.
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DR   AlphaFoldDB; G3USD2; -.
DR   MEROPS; A01.008; -.
DR   Ensembl; ENSMGAT00000019567.2; ENSMGAP00000018605.2; ENSMGAG00000002701.3.
DR   GeneTree; ENSGT00940000157898; -.
DR   HOGENOM; CLU_013253_3_3_1; -.
DR   InParanoid; G3USD2; -.
DR   Proteomes; UP000001645; Chromosome 28.
DR   Bgee; ENSMGAG00000002701; Expressed in liver and 9 other cell types or tissues.
DR   GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR   GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR   GO; GO:0004190; F:aspartic-type endopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR   GO; GO:0002003; P:angiotensin maturation; IEA:Ensembl.
DR   GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR   GO; GO:0043408; P:regulation of MAPK cascade; IEA:Ensembl.
DR   Gene3D; 2.40.70.10; Acid Proteases; 2.
DR   InterPro; IPR001461; Aspartic_peptidase_A1.
DR   InterPro; IPR001969; Aspartic_peptidase_AS.
DR   InterPro; IPR033121; PEPTIDASE_A1.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   PANTHER; PTHR47966; BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED; 1.
DR   PANTHER; PTHR47966:SF24; RENIN; 1.
DR   Pfam; PF00026; Asp; 1.
DR   PRINTS; PR00792; PEPSIN.
DR   SUPFAM; SSF50630; Acid proteases; 1.
DR   PROSITE; PS00141; ASP_PROTEASE; 2.
DR   PROSITE; PS51767; PEPTIDASE_A1; 1.
PE   3: Inferred from homology;
KW   Aspartyl protease {ECO:0000256|RuleBase:RU000454};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR601461-2};
KW   Hydrolase {ECO:0000256|RuleBase:RU000454};
KW   Protease {ECO:0000256|RuleBase:RU000454};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001645}.
FT   DOMAIN          141..459
FT                   /note="Peptidase A1"
FT                   /evidence="ECO:0000259|PROSITE:PS51767"
FT   ACT_SITE        159
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   ACT_SITE        347
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-1"
FT   DISULFID        170..179
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
FT   DISULFID        338..342
FT                   /evidence="ECO:0000256|PIRSR:PIRSR601461-2"
SQ   SEQUENCE   462 AA;  49850 MW;  74D2CAA6F8F18777 CRC64;
     MAQQHLSLHS NLQHDAFHLQ NQRAEPQHIT NPPVCAGYPY STVSPYPRIP LRGRDPAGSC
     CHLELGSSRA GRCGLLGVST APSSARRIAL RRMPSIRQTL QEMGVKVSDV FPELRQRRGG
     AGGPQNGTAP TLLTNYLDTQ YYGEISIGTP PQTFKVVFDT GSANLWVPSC KCSPLYSACI
     SHSRYDSSKS RTYIANGTGF AIRYGTGSVK GFLSQDVVMV SDIPIIQVFA EATVLPAFPF
     IFARFDGVLG MGYPSQAIDG ITPVFDRIIS QQILKEDVSP PYVLHSRNAP LKPGGEIILG
     GTDPAYYTGD FHYLSISRNG YWQISMKGVS VGAEILFCKE GCSVAIDTGA SYITGPAGPV
     SVLMKAIGAA EMTEGEYVVD CEKVPQLPNI SFHLGGKAYT LSGSAYVLRV SCYGEDICVV
     ALSGLDVPPP AGPLWILGAS FIGHYYTKFD RRNNRIGFAT AR
//
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