ID G3UV43_MELGA Unreviewed; 1672 AA.
AC G3UV43;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN Name=LOC100542338 {ECO:0000313|Ensembl:ENSMGAP00000019712.2};
OS Meleagris gallopavo (Wild turkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Meleagridinae; Meleagris.
OX NCBI_TaxID=9103 {ECO:0000313|Ensembl:ENSMGAP00000019712.2, ECO:0000313|Proteomes:UP000001645};
RN [1] {ECO:0000313|Ensembl:ENSMGAP00000019712.2, ECO:0000313|Proteomes:UP000001645}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20838655; DOI=10.1371/journal.pbio.1000475;
RA Dalloul R.A., Long J.A., Zimin A.V., Aslam L., Beal K., Blomberg L.A.,
RA Bouffard P., Burt D.W., Crasta O., Crooijmans R.P., Cooper K.,
RA Coulombe R.A., De S., Delany M.E., Dodgson J.B., Dong J.J., Evans C.,
RA Frederickson K.M., Flicek P., Florea L., Folkerts O., Groenen M.A.,
RA Harkins T.T., Herrero J., Hoffmann S., Megens H.J., Jiang A., de Jong P.,
RA Kaiser P., Kim H., Kim K.W., Kim S., Langenberger D., Lee M.K., Lee T.,
RA Mane S., Marcais G., Marz M., McElroy A.P., Modise T., Nefedov M.,
RA Notredame C., Paton I.R., Payne W.S., Pertea G., Prickett D., Puiu D.,
RA Qioa D., Raineri E., Ruffier M., Salzberg S.L., Schatz M.C., Scheuring C.,
RA Schmidt C.J., Schroeder S., Searle S.M., Smith E.J., Smith J.,
RA Sonstegard T.S., Stadler P.F., Tafer H., Tu Z.J., Van Tassell C.P.,
RA Vilella A.J., Williams K.P., Yorke J.A., Zhang L., Zhang H.B., Zhang X.,
RA Zhang Y., Reed K.M.;
RT "Multi-platform next-generation sequencing of the domestic turkey
RT (Meleagris gallopavo): genome assembly and analysis.";
RL PLoS Biol. 8:E1000475-E1000475(2010).
RN [2] {ECO:0000313|Ensembl:ENSMGAP00000019712.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|ARBA:ARBA00009535, ECO:0000256|PIRNR:PIRNR002290}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003210892.1; XM_003210844.3.
DR Ensembl; ENSMGAT00000019970.2; ENSMGAP00000019712.2; ENSMGAG00000000798.3.
DR GeneID; 100542338; -.
DR KEGG; mgp:100542338; -.
DR GeneTree; ENSGT00950000183166; -.
DR HOGENOM; CLU_002136_0_0_1; -.
DR TreeFam; TF300059; -.
DR Proteomes; UP000001645; Chromosome 17.
DR Bgee; ENSMGAG00000000798; Expressed in pectoralis major and 17 other cell types or tissues.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 4.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR015348; Clathrin_H-chain_linker_core.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF6; CLATHRIN HEAVY CHAIN 2; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF09268; Clathrin-link; 1.
DR Pfam; PF13838; Clathrin_H_link; 1.
DR Pfam; PF01394; Clathrin_propel; 5.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 6.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 7.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|ARBA:ARBA00023176, ECO:0000256|PIRNR:PIRNR002290};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000001645};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 331..354
FT /note="Clathrin heavy chain linker core motif"
FT /evidence="ECO:0000259|Pfam:PF09268"
SQ SEQUENCE 1672 AA; 191077 MW; CCAE2D1C50D51C98 CRC64;
MAQILPIRFQ EHFQLQNLGI NPANIGFSTL TMESDKFICI REKVGEQAQV VIIDMSDPTS
PIRRPISAES AIMNPASKVI ALKAGKTLQI FNIEMKSKMK AHAMAEEVIF WKWISVNTVA
LVTETAVYHW SMEGESQPQK MFDRHASLAG CQIINYRTDE HQKWLLLIGI SAQQNRVVGA
MQLYSVDRKV SQPIEGHAAA FAEFKIEGNA KPSTLFCFAV RSPAGGKLHI IEVGQPATGN
QPFVKKAVDV FFPPEAQTDF PVAMQIGIKH GVIYLITKYG YIHVYDLESG VCIYMNRISA
DTIFVTASHE PTSGIIGVNK KGQVLSVCVE EDNIVNYATN VLQNPDLGLR MAIRSNLAGA
EELFARKFNT LFAQGSYADA AKVAASAPKG ILRTSDTIRK FQSVPAQPGH ASPLLQYFGI
LLDQGQLNKF ESLELCRPVL QQGRKQLLEK WLKEDKLECS EELGDLVKTA DPTLALSVYL
RANVPNKVIQ CFAETGQFQK IVLYAKKVGY TPDWIFLLRS VMRVSPEQGL QFSQMLVQDE
EPLANINQIV DVFMENSLIQ QCTSFLLDAL KNNRPAEGHL QTRLLEMNLI HAPQVADAIL
GNQMFTHYDR AHIAQLCEKA GLLQRALEHY TDLYDIKRAV VHTHLLNPEW LVNFFGSLSV
EDSVECLRAM LSANIRQNLQ LCVQVASKYH EQLGTQSLVE LFESFKSYEG LFYFLGSIVN
FSQDPDVHFK YIQAACKTGQ IKEVERICRE SNCYNPERVK NFLKEAKLTD QLPLIIVCDR
FDFVHDLVLY LYRNSLQKYI EIYVQKVNPS RIPAVVGGLL DVDCSEDVIK NLIMVVRGQF
STDELVAEVE KRNRLKLLLP WLESRIHEGC EEPATHNALA KIYIDSNNNP ERFLRENPYY
DSRVVGKYCE KRDPHLACVA YERGQCDLEL IKVCNENSLF KSEARYLVRR KDPELWANVL
EENNPFRRQL IDQVVQTALS ETQDPEEVSV TVKAFMTADL PNELIELLEK IVLDNSVFSE
HRNLQNLLIL TAIKADRTRV MEYINRLDNY DAPDIANIAI SNELYEEAFA IFRKFDVNTS
AIQVLIEHIG NLDRAYEFAE RCNEPAVWSQ LARAQLQKNL VKEAIDSYIK ADDPSAYMEV
VQAANRNDNW EDLVKFLQMA RKKARESYVE TELIFAFAKT NRLSELEEFI SGPNNAHIQQ
VGDRCYEEDM YEAAKLLYNN VSNFARLAST LVHLGEYQAA VDSGRKANST RTWKEVCFAC
VDGREFRLAQ ICGLHIVIHA DELEELISYY QDRGYFEELI ALLEAALGLE RAHMGMFTEL
AILYSKFKPQ KMREHLELFW SRVNIPKVLR AAEQAHLWAE LVFLYDKYEE YDNAIITMMN
HPTDAWKEGQ FKDIIAKVAN VELYYKALQF YLDYKPLLIN DLLLVLSPRL DHTRTVNFFS
KVNQLLLVKP YLRSVQNHNN KGVNEALNNL LTQEEDYQGL RASIDAYDNF DNIALAQRLE
KHELIEFRRI AAYLYKGNNR WKQSVELCKK DHLYKDAMQY AAESKDVELA EKLLQWFLEE
GKQECFAACL FTCYDLLHPD VVLELAWRHN IMDFAMPYFV QVMREYLTKV DNLDASESLR
KEEEQVTEPT PIVFGQQLML TAGPSAVPPQ TNFPYGYTAP GFTQPPVYGF NM
//
