GenomeNet

Database: UniProt
Entry: G3UWI6_MOUSE
LinkDB: G3UWI6_MOUSE
Original site: G3UWI6_MOUSE 
ID   G3UWI6_MOUSE            Unreviewed;       807 AA.
AC   G3UWI6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 50.
DE   SubName: Full=Short transient receptor potential channel 7 {ECO:0000313|Ensembl:ENSMUSP00000133305};
GN   Name=Trpc7 {ECO:0000313|Ensembl:ENSMUSP00000133305,
GN   ECO:0000313|MGI:MGI:1349470};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133305, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000133305, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133305,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000133305}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133305};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000133305}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AC132322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC132886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3UWI6; -.
DR   MaxQB; G3UWI6; -.
DR   PRIDE; G3UWI6; -.
DR   Ensembl; ENSMUST00000174457; ENSMUSP00000133305; ENSMUSG00000021541.
DR   MGI; MGI:1349470; Trpc7.
DR   GeneTree; ENSGT00760000119180; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   Bgee; ENSMUSG00000021541; -.
DR   ExpressionAtlas; G3UWI6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0006828; P:manganese ion transport; IEA:Ensembl.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 2.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005463; TRPC7_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF64; PTHR10117:SF64; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   PRINTS; PR01648; TRPCHANNEL7.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00844120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    524    547       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    595    617       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       51    128       ANK_REP_REGION. {ECO:0000259|Pfam:
FT                                PF12796}.
FT   DOMAIN      198    260       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      338    628       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   807 AA;  93323 MW;  D14A260BA0C13B37 CRC64;
     MLGSNTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR
     KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR
     IVEAILSHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV
     HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL
     TALELSNELA RLANIETEFK NDYRKLSMQC KDFVVGVLDL CRDTEEVEAI LNGDVNLQVW
     SDHHRPSLSR IKLAIKYEVK KLGQTLRSPF MKFVAHAVSF TIFLGLLVVN ASDRFEGVKT
     LPNETFTDYP KQIFRVKTTQ FSWTEMLIMK WVLGMIWSEC KEIWEEGPRE YVLHLWNLLD
     FGMLSIFVAS FTARFMAFLK ASEAQLYVDQ YVQDVTLHNV SLPPEVAYFT YARDKWWPSD
     PQIISEGLYA IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVI FIMVFVAFMI
     GMFNLYSYYR GAKYNPAFTT VEESFKTLFW SIFGLSEVIS VVLKYDHKFI ENIGYVLYGV
     YNVTMVVVLL NMLIAMINNS YQEIEEDADV EWKFARAKLW LSYFDEGRTL PAPFNLVPSP
     KSFYYLIMRI KMCLIELCQS KAKRCENDLE MGMLNSKFRK TRYQAGMRNS ENLTANSTFS
     KPTRYQKIMK RLIKRYVLKA QVDRENDEVN EGELKEIKQD ISSLRYELLE EKSQATGELA
     DLIQQLSEKF GKNLNKDHLR VNQGKDI
//
DBGET integrated database retrieval system