ID G3UY25_MOUSE Unreviewed; 228 AA.
AC G3UY25;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE SubName: Full=Tumor necrosis factor (ligand) superfamily, member 10 {ECO:0000313|Ensembl:ENSMUSP00000133917.2};
GN Name=Tnfsf10 {ECO:0000313|Ensembl:ENSMUSP00000133917.2,
GN ECO:0000313|MGI:MGI:107414};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000133917.2, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000133917.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133917.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000133917.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000133917.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR AlphaFoldDB; G3UY25; -.
DR SMR; G3UY25; -.
DR MaxQB; G3UY25; -.
DR ProteomicsDB; 320257; -.
DR Antibodypedia; 3728; 1433 antibodies from 51 providers.
DR Ensembl; ENSMUST00000174840.2; ENSMUSP00000133917.2; ENSMUSG00000039304.12.
DR UCSC; uc008otn.1; mouse.
DR AGR; MGI:107414; -.
DR MGI; MGI:107414; Tnfsf10.
DR VEuPathDB; HostDB:ENSMUSG00000039304; -.
DR GeneTree; ENSGT01070000253816; -.
DR HOGENOM; CLU_1214433_0_0_1; -.
DR ChiTaRS; Tnfsf10; mouse.
DR Proteomes; UP000000589; Chromosome 3.
DR Bgee; ENSMUSG00000039304; Expressed in small intestine Peyer's patch and 102 other cell types or tissues.
DR ExpressionAtlas; G3UY25; baseline and differential.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF27; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10; 1.
DR Pfam; PF00229; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 1: Evidence at protein level;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|EPD:G3UY25,
KW ECO:0007829|MaxQB:G3UY25};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..195
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 228 AA; 25988 MW; 7AE4B203A4422B55 CRC64;
MPSSGALKDL SFSQHFRMMV ICIVLLQVLL QAVSVAVTYM YFTNEMKQLQ DNYSKIGLAC
FSKTDEDFWD STDGEILNRP CLQVKRQLYQ LIEEVTLRTF QDTISTVPEK QLSTPPLPRG
GRPQKVAAHI TGITRRSNSA LIPISKDGKT LGQKIESWES SRKGHSFLNH VLFRNGELVI
EQEGLYYIYS QTYFRFQEAE DASKMVSKDK VVFKTSKRLP TSRTSTLS
//
