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Database: UniProt
Entry: G3UZW6_MOUSE
LinkDB: G3UZW6_MOUSE
Original site: G3UZW6_MOUSE 
ID   G3UZW6_MOUSE            Unreviewed;       746 AA.
AC   G3UZW6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 47.
DE   SubName: Full=Short transient receptor potential channel 7 {ECO:0000313|Ensembl:ENSMUSP00000134662};
GN   Name=Trpc7 {ECO:0000313|Ensembl:ENSMUSP00000134662,
GN   ECO:0000313|MGI:MGI:1349470};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000134662, ECO:0000313|Proteomes:UP000000589};
RN   [1] {ECO:0000313|Ensembl:ENSMUSP00000134662, ECO:0000313|Proteomes:UP000000589}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134662,
RC   ECO:0000313|Proteomes:UP000000589};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2] {ECO:0000313|Ensembl:ENSMUSP00000134662}
RP   IDENTIFICATION.
RC   STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000134662};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSMUSP00000134662}.
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DR   EMBL; AC132322; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC132886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   ProteinModelPortal; G3UZW6; -.
DR   MaxQB; G3UZW6; -.
DR   PaxDb; G3UZW6; -.
DR   PRIDE; G3UZW6; -.
DR   Ensembl; ENSMUST00000173513; ENSMUSP00000134662; ENSMUSG00000021541.
DR   MGI; MGI:1349470; Trpc7.
DR   eggNOG; KOG3609; Eukaryota.
DR   eggNOG; ENOG410XQ0Y; LUCA.
DR   GeneTree; ENSGT00760000119180; -.
DR   Proteomes; UP000000589; Chromosome 13.
DR   Bgee; ENSMUSG00000021541; -.
DR   ExpressionAtlas; G3UZW6; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR   GO; GO:0006828; P:manganese ion transport; IEA:Ensembl.
DR   CDD; cd00204; ANK; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR004729; TRP_channel.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR005463; TRPC7_channel.
DR   InterPro; IPR002153; TRPC_channel.
DR   PANTHER; PTHR10117; PTHR10117; 1.
DR   PANTHER; PTHR10117:SF64; PTHR10117:SF64; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 3.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   TIGRFAMs; TIGR00870; trp; 1.
PE   3: Inferred from homology;
KW   ANK repeat {ECO:0000256|SAAS:SAAS00844120};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000589};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    463    486       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    534    556       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       51    128       ANK_REP_REGION. {ECO:0000259|Pfam:
FT                                PF12796}.
FT   DOMAIN      198    260       TRP_2. {ECO:0000259|Pfam:PF08344}.
FT   DOMAIN      277    567       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   746 AA;  86223 MW;  89713E0A905BB059 CRC64;
     MLGSNTFKNM QRRHTTLREK GRRQAIRGPA YMFNEKGTSL TPEEERFLDS AEYGNIPVVR
     KMLEESKTLN FNCVDYMGQN ALQLAVGNEH LEVTELLLKK ENLARVGDAL LLAISKGYVR
     IVEAILSHPA FAQGQRLTLS PLEQELRDDD FYAYDEDGTR FSHDITPIIL AAHCQEYEIV
     HILLLKGARI ERPHDYFCKC NECTEKQRKD SFSHSRSRMN AYKGLASAAY LSLSSEDPVL
     TALELSNELA RLANIETEFK LGQTLRSPFM KFVAHAVSFT IFLGLLVVNA SDRFEGVKTL
     PNETFTDYPK QIFRVKTTQF SWTEMLIMKW VLGMIWSECK EIWEEGPREY VLHLWNLLDF
     GMLSIFVASF TARFMAFLKA SEAQLYVDQY VQDVTLHNVS LPPEVAYFTY ARDKWWPSDP
     QIISEGLYAI AVVLSFSRIA YILPANESFG PLQISLGRTV KDIFKFMVIF IMVFVAFMIG
     MFNLYSYYRG AKYNPAFTTV EESFKTLFWS IFGLSEVISV VLKYDHKFIE NIGYVLYGVY
     NVTMVVVLLN MLIAMINNSY QEIEEDADVE WKFARAKLWL SYFDEGRTLP APFNLVPSPK
     SFYYLIMRIK MCLIELCQSK AKRCENDLEM GMLNSKFRKT RYQAGMRNSE NLTANSTFSK
     PTRYQKIMKR LIKRYVLKAQ VDRENDEVNE GELKEIKQDI SSLRYELLEE KSQATGELAD
     LIQQLSEKFG KNLNKDHLRV NQGKDI
//
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