ID G3V2J9_HUMAN Unreviewed; 1281 AA.
AC G3V2J9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 79.
DE RecName: Full=Tubulin--tyrosine ligase-like protein 5 {ECO:0000256|ARBA:ARBA00041448};
GN Name=TTLL5 {ECO:0000313|Ensembl:ENSP00000450713.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000450713.1, ECO:0000313|Proteomes:UP000005640};
RN [1] {ECO:0000313|Ensembl:ENSP00000450713.1, ECO:0000313|Proteomes:UP000005640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12508121; DOI=10.1038/nature01348;
RA Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C.,
RA Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A.,
RA Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H.,
RA Du H., Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T.,
RA Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B.,
RA Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D.,
RA Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R.,
RA Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S.,
RA Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C.,
RA Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S.,
RA Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C.,
RA Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P.,
RA Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M.,
RA Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V.,
RA Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J.,
RA Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F.,
RA Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F.,
RA Waterston R., Hood L., Weissenbach J.;
RT "The DNA sequence and analysis of human chromosome 14.";
RL Nature 421:601-607(2003).
RN [2] {ECO:0000313|Ensembl:ENSP00000450713.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-glutamate + L-glutamyl-[protein] = ADP + gamma-L-
CC glutamyl-L-glutamyl-[protein] + H(+) + phosphate;
CC Xref=Rhea:RHEA:60144, Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:15517,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29973, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:143622,
CC ChEBI:CHEBI:456216; Evidence={ECO:0000256|ARBA:ARBA00036640};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:60145;
CC Evidence={ECO:0000256|ARBA:ARBA00036640};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AC007182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC009399; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AF107885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G3V2J9; -.
DR EPD; G3V2J9; -.
DR MassIVE; G3V2J9; -.
DR MaxQB; G3V2J9; -.
DR PeptideAtlas; G3V2J9; -.
DR ProteomicsDB; 32657; -.
DR Antibodypedia; 25856; 70 antibodies from 13 providers.
DR Ensembl; ENST00000557636.5; ENSP00000450713.1; ENSG00000119685.20.
DR UCSC; uc010ask.3; human.
DR HGNC; HGNC:19963; TTLL5.
DR VEuPathDB; HostDB:ENSG00000119685; -.
DR GeneTree; ENSGT00940000162939; -.
DR OMA; TRLFQDX; -.
DR PhylomeDB; G3V2J9; -.
DR ChiTaRS; TTLL5; human.
DR Proteomes; UP000005640; Chromosome 14.
DR Bgee; ENSG00000119685; Expressed in left testis and 207 other cell types or tissues.
DR ExpressionAtlas; G3V2J9; baseline and differential.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:HPA.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR12241; TUBULIN POLYGLUTAMYLASE; 1.
DR PANTHER; PTHR12241:SF145; TUBULIN POLYGLUTAMYLASE TTLL5; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:G3V2J9,
KW ECO:0007829|MaxQB:G3V2J9};
KW Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT REGION 410..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..628
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1087..1129
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1214..1248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 596..618
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1087..1127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1281 AA; 144229 MW; 99C2F08494207512 CRC64;
MPIVMARDLE ETASSSEDEE VISQEDHPCI MWTGGCRRIP VLVFHADAIL TKDNNIRVIG
ERYHLSYKIV RTDSRLVRSI LTAHGFHEVH PSSTDYNLMW TGSHLKPFLL RTLSEAQKVN
HFPRSYELTR KDRLYKNIIR MQHTHGFKAF HILPQTFLLP AEYAEFCNSY SKDRGPWIVK
PVASSRGRGV YLINNPNQIS LEENILVSRY INNPLLIDDF KFDVRLYVLV TSYDPLVIYL
YEEGLARFAT VRYDQGAKNI RNQFMHLTNY SVNKKSGDYV SCDDPEVEDY GNKWSMSAML
RYLKQEGRDT TALMAHVEDL IIKTIISAEL AIATACKTFV PHRSSCFELY GFDVLIDSTL
KPWLLEVNLS PSLACDAPLD LKIKASMISD MFTVVGFVCQ DPAQRASTRP IYPTFESSRR
NPFQKPQRPV SAQFQSSKAK QRCRPLSASD AEMKNLVGSA REKGPGKLGG SVLGLSMEEI
KVLRRVKEEN DRRGGFIRIF PTSETWEIYG SYLEHKTSMN YMLATRLFQD RMTADGAPEL
KIESLNSKAK LHAALYERKL LSLEVRKRRR RSSRLRAMRP KYPVITQPAE MNVKTETESE
EEEEVALDNE DEEQEASQEE SAGFLRENQA KYTPSLTALV ENTPKENSMK VREWNNKGGH
CCKLETQELE PKFNLMQILQ DNGNLSKMQA RIAFSAYLQH VQIRLMKDSG GQTFSASWAA
KEDEQMELVV RFLKRASNNL QHSLRMVLPS RRLALLERRR ILAHQLGDFI IVYNKETEQM
AEKKSKKKVE EEEEDGVNME NFQEFIRQAS EAELEEVLTF YTQKNKSASV FLGTHSKISK
NNNNYSDSGA KGDHPETIME EVKIKPPKQQ QTTEIHSDKL SRFTTSAEKE AKLVYSNSSS
GPTATLQKIP NTHLSSVTTS DLSPGPCHHS SLSQIPSAIP SMPHQPTILL NTVSASASPC
LHPGAQNIPS PTGLPRCRSG SHTIGPFSSF QSAAHIYSQK LSRPSSAKAA GSCYLNKHHS
GIAKTQKEGE DASLYSKRYN QSMVTAELQR LAEKQAARQY SPSSHINLLT QQVTNLNLAT
GIINRSSASA PPTLRPIISP SGPTWSTQSD PQAPENHSSS PGSRSLQTGG FAWEGEVENN
VYSQATGVVP QHKYHPTAGS YQLQFALQQL EQQKLQSRQL LDQSRARHQA IFGSQTLPNS
NLWTMNNGAG CRISSATASG QKPTTLPQKV VPPPSSCASL VPKPPPNHEQ VLRRATSQKA
SNTRFRSSFQ NYLWYFFQAV S
//
