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Database: UniProt
Entry: G3VGX7_SARHA
LinkDB: G3VGX7_SARHA
Original site: G3VGX7_SARHA 
ID   G3VGX7_SARHA            Unreviewed;       836 AA.
AC   G3VGX7;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   05-JUL-2017, entry version 23.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A4 {ECO:0000313|Ensembl:ENSSHAP00000002431};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002431, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000002431}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000002431}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000002431}.
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DR   EMBL; AEFK01205113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSSHAT00000002457; ENSSHAP00000002431; ENSSHAG00000002153.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    398    427       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    466       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    545    566       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    572    592       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    642    661       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    768    792       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   836 AA;  95428 MW;  C4D8C7675A602E8C CRC64;
     MASVFRSEEM CLSQLFLQAE AAYCCVAELG ELGLVQFKDL NANVNSFQRK FVNEVRRCES
     LERILRFLED EMKEEIVIQV PEKSPQTPLP REMIDLEIIL EKLEGELQEA NQNQQALRTN
     FLQLTELKYL LKKTEDFFET ENSLNDDFFT EDTSGLLELK SVPSPVAGKL GFTAGVINRE
     RMAPFERLLW RVCRGNVYLK YTEIDTLLED PVTKEELKKN IFIIFYQGDQ LKKKVNKICE
     GFRATVYPCP EVASERREML ANVNVRLEDL NTVITQTESH RQRLLQEAAA NWYSWSIKVQ
     KMKAIYHVLN CCNIDVTQQC IIAEIWFPVA DTVAIKTALQ QGVDRSGSPI APIMTAVEMK
     STPPTFNRSN KFTAGFQNIV DAYGVGNYRE MNPTPYTIIT FPFLFAVMFG DCGHGAIMLI
     LALWMVMNEK SLLAQKNTNE IWNTFFNGRY LILLMGFFSV YTGFIYNDCF SKALNIFGSS
     WSVRSMFTNG TWNSHLVETN PILQLDPAVP GVFSGNPYPF GIDPVWNIAA NKLTFLNSYK
     MKMSVILGII QMVFGVILSL FNHIYFRKTI NIVLQFIPEM IFILCLFGYL VFMVIFKWCQ
     YDVYTSRSAP SILIHFINMF LFNYDDPTSK PLYAHQKEVQ SFLVIFALIA VPWMLLIKPF
     ILRARHRKSQ ALLNNAAADI EADGSSHSKS AGKENSAGAQ GGHDDHEEEF NFGDIFVHQA
     IHTIEYCLGC ISNTASYLRL WALSLAHSQL SEVLWTMVMN IGLRQRSWGG LIGVFIIFAF
     FAVLTVAILL VMEGLSAFLH ALRLHWVEFQ NKFYSGCGYK FTPFSFKVIL DGTAEE
//
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