ID G3VGX7_SARHA Unreviewed; 836 AA.
AC G3VGX7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 28-MAR-2018, entry version 25.
DE RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN Name=ATP6V0A4 {ECO:0000313|Ensembl:ENSSHAP00000002431};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002431, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002431}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered
RT marsupial Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002431}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2011) to UniProtKB.
CC -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC ATPase), a multimeric enzyme that catalyzes the translocation of
CC protons across the membranes. Required for assembly and activity
CC of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC {ECO:0000256|RuleBase:RU361189}.
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DR EMBL; AEFK01205113; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSSHAT00000002457; ENSSHAP00000002431; ENSSHAG00000002153.
DR eggNOG; KOG2189; Eukaryota.
DR eggNOG; COG1269; LUCA.
DR GeneTree; ENSGT00390000004941; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR InterPro; IPR002490; V-ATPase_116kDa_su.
DR InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR PANTHER; PTHR11629; PTHR11629; 1.
DR Pfam; PF01496; V_ATPase_I; 1.
DR PIRSF; PIRSF001293; ATP6V0A1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW Ion transport {ECO:0000256|RuleBase:RU361189};
KW Membrane {ECO:0000256|RuleBase:RU361189};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|RuleBase:RU361189};
KW Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW Transport {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 398 427 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 447 466 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 545 566 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 572 592 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 642 661 Helical. {ECO:0000256|RuleBase:RU361189}.
FT TRANSMEM 768 792 Helical. {ECO:0000256|RuleBase:RU361189}.
FT COILED 58 78 {ECO:0000256|SAM:Coils}.
FT COILED 93 127 {ECO:0000256|SAM:Coils}.
FT COILED 267 287 {ECO:0000256|SAM:Coils}.
SQ SEQUENCE 836 AA; 95428 MW; C4D8C7675A602E8C CRC64;
MASVFRSEEM CLSQLFLQAE AAYCCVAELG ELGLVQFKDL NANVNSFQRK FVNEVRRCES
LERILRFLED EMKEEIVIQV PEKSPQTPLP REMIDLEIIL EKLEGELQEA NQNQQALRTN
FLQLTELKYL LKKTEDFFET ENSLNDDFFT EDTSGLLELK SVPSPVAGKL GFTAGVINRE
RMAPFERLLW RVCRGNVYLK YTEIDTLLED PVTKEELKKN IFIIFYQGDQ LKKKVNKICE
GFRATVYPCP EVASERREML ANVNVRLEDL NTVITQTESH RQRLLQEAAA NWYSWSIKVQ
KMKAIYHVLN CCNIDVTQQC IIAEIWFPVA DTVAIKTALQ QGVDRSGSPI APIMTAVEMK
STPPTFNRSN KFTAGFQNIV DAYGVGNYRE MNPTPYTIIT FPFLFAVMFG DCGHGAIMLI
LALWMVMNEK SLLAQKNTNE IWNTFFNGRY LILLMGFFSV YTGFIYNDCF SKALNIFGSS
WSVRSMFTNG TWNSHLVETN PILQLDPAVP GVFSGNPYPF GIDPVWNIAA NKLTFLNSYK
MKMSVILGII QMVFGVILSL FNHIYFRKTI NIVLQFIPEM IFILCLFGYL VFMVIFKWCQ
YDVYTSRSAP SILIHFINMF LFNYDDPTSK PLYAHQKEVQ SFLVIFALIA VPWMLLIKPF
ILRARHRKSQ ALLNNAAADI EADGSSHSKS AGKENSAGAQ GGHDDHEEEF NFGDIFVHQA
IHTIEYCLGC ISNTASYLRL WALSLAHSQL SEVLWTMVMN IGLRQRSWGG LIGVFIIFAF
FAVLTVAILL VMEGLSAFLH ALRLHWVEFQ NKFYSGCGYK FTPFSFKVIL DGTAEE
//
