ID G3VGY1_SARHA Unreviewed; 1392 AA.
AC G3VGY1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Regulator of G protein signaling 12 {ECO:0000313|Ensembl:ENSSHAP00000002435.2};
GN Name=RGS12 {ECO:0000313|Ensembl:ENSSHAP00000002435.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000002435.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000002435.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000002435.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR Ensembl; ENSSHAT00000002461.2; ENSSHAP00000002435.2; ENSSHAG00000002156.2.
DR GeneTree; ENSGT00940000159741; -.
DR HOGENOM; CLU_002190_0_0_1; -.
DR InParanoid; G3VGY1; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd13162; PTB_RGS12; 1.
DR CDD; cd17136; RBD1_RGS12; 1.
DR CDD; cd17138; RBD2_RGS12; 1.
DR CDD; cd08742; RGS_RGS12; 1.
DR Gene3D; 1.10.196.10; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.167.10; Regulator of G-protein Signalling 4, domain 2; 1.
DR InterPro; IPR003109; GoLoco_motif.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR006020; PTB/PI_dom.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR016137; RGS.
DR InterPro; IPR046995; RGS10/12/14-like.
DR InterPro; IPR037880; RGS12_RGS.
DR InterPro; IPR036305; RGS_sf.
DR InterPro; IPR024066; RGS_subdom1/3.
DR InterPro; IPR044926; RGS_subdomain_2.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR45945:SF1; REGULATOR OF G-PROTEIN SIGNALING 12; 1.
DR PANTHER; PTHR45945; REGULATOR OF G-PROTEIN SIGNALING LOCO; 1.
DR Pfam; PF02188; GoLoco; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00615; RGS; 1.
DR Pfam; PF16613; RGS12_us1; 1.
DR Pfam; PF16611; RGS12_us2; 1.
DR Pfam; PF16612; RGS12_usC; 1.
DR PRINTS; PR01301; RGSPROTEIN.
DR SMART; SM00390; GoLoco; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00462; PTB; 1.
DR SMART; SM00455; RBD; 2.
DR SMART; SM00315; RGS; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48097; Regulator of G-protein signaling, RGS; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 2.
DR PROSITE; PS50877; GOLOCO; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS01179; PID; 1.
DR PROSITE; PS50898; RBD; 2.
DR PROSITE; PS50132; RGS; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 22..95
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 230..342
FT /note="PID"
FT /evidence="ECO:0000259|PROSITE:PS01179"
FT DOMAIN 711..828
FT /note="RGS"
FT /evidence="ECO:0000259|PROSITE:PS50132"
FT DOMAIN 958..1028
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1030..1100
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT REGION 507..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 619..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1221..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 838..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..893
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 906..924
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 925..939
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1128..1149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1164
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1263..1279
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1359..1392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1392 AA; 152905 MW; FDE0D2A9236F5085 CRC64;
MYKPAETVKR RLNVHAPPRI RSVDVARGRA GYGFTLSGQA PCVLSCVMKG SPADYVGLKA
GDQIFAVNDI NVKKASHEDV VKLIGKCSGV LHMIICEGIS HMDSCSSDEE VGFYEGKGWL
KPKLDSKALG INRAERVVEE MQSGGIFSMI FENPTLCAAS SDHSKLKQRS LSESAAAASR
FDIAQESLTS PNYNLHSKDE MSKVIHDDSV FSIGLENHDD FGLDASILNV AMVVGYLGSI
ELPSTSSNLE YDSLQAIRGC MRRLRAEQKI HSLVMMKIMH DCIQLCTDKA GVVAEYPAEK
LAFSAVCPDD RRFFGLVTMQ TNDDGSLAQE DEGVLRTSCH VFMVDPELFS HKIHQGIARR
FGFDCTADPD TNGCLEFPTS SLPVLQFISV LYRDMGELIE GMRARAFLDG DADAHQNNST
SSNSDSGIGN FNQEEKSNRV LVVDLGGSSS KHIPSNLWEN PGGRAPNLPA AHWNGFCHDS
EGSSLEPTQN DKFCELNKHL GPSSRMEIPL VSSRSSVPPS KRSATGMGGG ANQRWLPVHV
LQEWQHGHAS DQESYTDSTD GWSSVNCGTL PPPMNKIPAD RYRVEGSFVQ PQLSAHKSEW
SKKAFGMQNF FGPHRNVRKM KEDKKSSKFG IGLLPTPQRT STRRSFGRSK RFSITRSLDD
LESATVSDGE LNSTDLKDCV SNNSLSSNAS LPSVQSCRRL RERRVASWAV SFERLLQDPI
GVRYFSDFLR KEFSEENILF WQACEYFSHV PAHDKKELSY RAREIFTKFL CSKATTPVNI
DSQAQLADDI LNAPHPDMFK EQQLQIFNLM KFDSYTRFLK SQLYQECILA EVEGRSLPDS
QQVPSSPASK HSISSDRSNV STPKKLSGKS KSGRSLNEES GEEDGEKKRK GTFFSWSRNK
STGRSQKKKE HGDHPHDTLH SNGGLHRRES QGSMSSGASL DLSDTFRVSV AEKDKSSKHC
CINLPDGTSC VVVVKSGFSI KEILSGLCEK HGINVAAVDL FLVGGDKPLV LHQDSSILDS
RDLRLEKRTL FRLDLVPINR SVGLKAKPTK PVTEVLRPVV AKYGLNLSDL VVRLSGEKEP
LDLGVPISNL DGQRVILEEK DPTKGKVFTD KQKGASAKQN IAVIPSSRNH SATGEERTLG
KSNSIKIKGE NGKNARDPRL SKREESIAKI GKKKYQKINL DEAEEFFELI SKAQSNRADD
QRGLLRKEDL VLPEFLRLPP CAAEPTASTP AAAKGLSKRT VKNGSKEKAA QPNGKLESPP
SGPESPAKSP GPAESKPRPP LAALPTQKSY SGPFSAPLSP IPRVQEAQIW KRQSEELPGE
GIQTIDDDNV ADLTLVGEGD ISSPNSTLLP PPPTPPSDAT KLTEANYTPP TPLTDKQEKP
GYQRSVSGIS RF
//
