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Database: UniProt
Entry: G3VLH0_SARHA
LinkDB: G3VLH0_SARHA
Original site: G3VLH0_SARHA 
ID   G3VLH0_SARHA            Unreviewed;      1518 AA.
AC   G3VLH0;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 36.
DE   SubName: Full=Transient receptor potential cation channel subfamily M member 2 {ECO:0000313|Ensembl:ENSSHAP00000004025};
GN   Name=TRPM2 {ECO:0000313|Ensembl:ENSSHAP00000004025};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004025, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000004025}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000004025}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000004025}.
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DR   EMBL; AEFK01182664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01182665; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01182666; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000004025; -.
DR   Ensembl; ENSSHAT00000004065; ENSSHAP00000004025; ENSSHAG00000003548.
DR   eggNOG; KOG3614; Eukaryota.
DR   eggNOG; KOG4195; Eukaryota.
DR   eggNOG; ENOG410XR5B; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; G3VLH0; -.
DR   OMA; GSHTGVM; -.
DR   OrthoDB; EOG091G035A; -.
DR   TreeFam; TF314204; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:Ensembl.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:Ensembl.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0047631; F:ADP-ribose diphosphatase activity; IEA:InterPro.
DR   GO; GO:0099604; F:ligand-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:Ensembl.
DR   GO; GO:0098703; P:calcium ion import across plasma membrane; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0071415; P:cellular response to purine-containing compound; IEA:Ensembl.
DR   GO; GO:0071502; P:cellular response to temperature stimulus; IEA:Ensembl.
DR   GO; GO:0002407; P:dendritic cell chemotaxis; IEA:Ensembl.
DR   GO; GO:0097028; P:dendritic cell differentiation; IEA:Ensembl.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:Ensembl.
DR   GO; GO:0009408; P:response to heat; IEA:Ensembl.
DR   GO; GO:0033194; P:response to hydroperoxide; IEA:Ensembl.
DR   GO; GO:0001659; P:temperature homeostasis; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000086; NUDIX_hydrolase_dom.
DR   InterPro; IPR015797; NUDIX_hydrolase_dom-like.
DR   InterPro; IPR029594; TRPM2.
DR   PANTHER; PTHR13800:SF2; PTHR13800:SF2; 2.
DR   Pfam; PF00520; Ion_trans; 1.
DR   SUPFAM; SSF55811; SSF55811; 1.
DR   PROSITE; PS51462; NUDIX; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    758    779       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    800    823       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    874    894       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    939    960       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1028   1050       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1369   1513       Nudix hydrolase. {ECO:0000259|PROSITE:
FT                                PS51462}.
SQ   SEQUENCE   1518 AA;  173307 MW;  54113D7ACC9398BE CRC64;
     MEPSRLKKTS SEEEEGDEED DGYIIPRKKT SKLEMVPNLR RSNSGRSKNK RRQYAFGSNE
     KENLSSWIPE NIKKKECVYF VESSKTSDSG KVVCECGYTR EQHLEEATKP QVFQGKEWDL
     KKHVQEMPTD AFGDIVFTGL GQKVGKYVRV SQDTPPGVIY HLMTQHWGLD VPNLLISVTG
     GAKNFNMKVR LKSIFRRGLV KVAQTTGAWI ITGGSHAGVM KQVGEAVRDF SLSSSYKEGE
     VITIGIATWG TVHNRESLIY PTGGFPAEYI LDEESQGNLS CLDSNHSHFI LVDDGTHGRY
     GVEILLRTKL EKFISEQTKE RGGVAIKIPI VCVVLEGGPG TLDTIFNAMT NGTPCVIVEG
     SGRVADVIAQ VANLPISEIT ISLIQKKLSL LFHETFETFT ESKIVEWTKK IQDIVRKRQL
     LTIYREGKNG QQDVDVAILQ ALLKAPASRN HDHVGHENWD HQLKLAVAWN RVDIARSEIF
     TDERQWKPSD LHPMMAAALI TNKPEFVKLF LENGVRLKEF VTWDTLIYLY ENLAPSSLFH
     SKLQKVLMEE MERSAYSSLP KIQMHHVSQV LRELLGDFTQ PLYPKPKHSE RPRLSLAVPH
     IKLNVQGVSL RSLYKRSPGR VTFTMDPVRD LLIWAIVQNR KELAEIIWAQ SQDCIAAALA
     CSKILKELSK EEDDTDSSEE MLTLAEEYEH RAIGVFTECY RKDEERAQKL LIRVSEAWGK
     TTCLQLALEA KDMKFVSHGG IQAFLTKVWW GQLCVDNGLW RVILCMLMFP LLYTGIISFR
     EKRLQPVSCL ARFRAFFTAP VVIFHLNILS YFTFLWLFAY VLMIDFQPTP SWREYVIYFW
     LFSLVCEETR QLFYDPDGFG LLKMASLYFN DFWNKLDVGA ILIFIAGLTC RLIPATLYPG
     RIILSLDFIM FCLRLMHIFT VSKTLGPKII IVKRMMKDVF FFLFLLAVWV VSFGVAKQAI
     LIHNESRVDW IFRGVVYHSY LTIFGQIPTY IDGVNFNPEQ CSPNGTDPYK PKCPESSEVS
     NKPVFPEWLT VILLCLYLLF TNILLLNLLI ARFKGGDTME GEEGLRGDDR SPWSWRQGPS
     GQRGLGRSKV LDGPSLRGLL PSSALGTTGR AWGAPGPRGA RFSFSASLPS EKKLEKNEEA
     TLLSWEIYLK ENYLQSQQYQ LKQRTDQKIE DMGNKIDIMM DLLDLDHLKR LGSVEQRLGY
     LEEQMFQSTK ALTWIIRALR DNGFGSEEDV PVKMPEGKEY DPGDKQEDTE DLYHVNARHL
     LYPNSTVTRF PVPNEKVPWE QEFHIYDPPF YTAERKEKAT SDPVGNSLES LSRINYNTMD
     GLINRQSFHG PYMVQDGLSL NPMGRTGLRG RGSLCCFGPN HALHPVITRW RRNQDGAICR
     KSIKKMLEIL VVKHALSEHW ALPGGSLEPG EILPRKLKRI LSQEFWQYFE TLLKQGAEVY
     KGYVDDPRNT DNAWIETIAI SVHFKDQNDL ELKRLNSHLQ VCDPEVSIRW QVVDKRIPLY
     ANHKEILQKA SALFGAYY
//
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