ID G3VLW9_SARHA Unreviewed; 684 AA.
AC G3VLW9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Netrin-1 {ECO:0000256|ARBA:ARBA00015919};
GN Name=LOC100920534 {ECO:0000313|Ensembl:ENSSHAP00000004174.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004174.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004174.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004174.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
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DR AlphaFoldDB; G3VLW9; -.
DR STRING; 9305.ENSSHAP00000004174; -.
DR Ensembl; ENSSHAT00000004215.2; ENSSHAP00000004174.2; ENSSHAG00000003679.2.
DR eggNOG; KOG0994; Eukaryota.
DR GeneTree; ENSGT00940000165132; -.
DR HOGENOM; CLU_016961_2_1_1; -.
DR InParanoid; G3VLW9; -.
DR TreeFam; TF352481; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR CDD; cd00055; EGF_Lam; 3.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 1.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR008211; Laminin_N.
DR InterPro; IPR002049; LE_dom.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR10574:SF431; LAMININ G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00053; Laminin_EGF; 3.
DR Pfam; PF00055; Laminin_N; 1.
DR Pfam; PF01759; NTR; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00180; EGF_Lam; 3.
DR SMART; SM00136; LamNT; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 3.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS01248; EGF_LAM_1; 1.
DR PROSITE; PS50027; EGF_LAM_2; 2.
DR PROSITE; PS51117; LAMININ_NTER; 1.
DR PROSITE; PS50189; NTR; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..684
FT /note="Netrin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029759662"
FT DOMAIN 31..267
FT /note="Laminin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51117"
FT DOMAIN 333..395
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 396..449
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 516..644
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 363..372
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 423..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 684 AA; 76316 MW; D85B399AA8F0048C CRC64;
MAALGLALIL LLESAVSGSG EAGKFHTFRC DHHACNPPVG NLATGRIPIT FTTCGESGTE
LSCFYVDQPA LPSNTLNCGH LQCTKCNAQQ PNNSHPPSSM TDNVFITPST WWQSAPGISR
EEVRLDFETE FYLTHVIVVF KSPRPAAMIL ERSQDGGHTW RPYKYFATNC TATFGLQDDL
TEEGSLCTSR YSDAIPCTRG EVIYRALTPT NQIADPYGPE AQDLLKLTNL RLLLLKRQDC
PCQGMRLLEK PQRFTHYAIY DLIVRGSCFC NGHGEMCRPV DEMGDSRNKV HGACVCRHHT
AGLHCEKCLP LYNDQPWKPG DGKTNQPNEC KKCRCHNHAD SCHFDEDVWL SSGKRRGGIC
DNCRHHTEGR HCQKCKSGFY RDWSKPMSSP EVCKPCSCQP LGSSNETSHK GFPCHPKTGY
CLCKPGVAGP HCDRCLVGYW GFGGNGCRPC NCSGACDPHT GACLSGHEKE PFLHIPVGGQ
IPDLVQGPGN DSEEPEPLRW DGQEQGFSAL RHPEKCVCKE KAVGKVRDFC QMKYAYVIKA
KILSAYDKGT HAEVWVKVKK VLKSGQMKIS RSHQSIYPES WTHRGCTCPI LNPGTDYLIA
GQEDPKNSKL LVNMNSLVKP WKVYLGKQCY KWKIRIYHWM PYFVIYYGEG KLEAPWFGGK
GADFGPRCCY LLPEPVCEPG FLHQ
//
