ID G3VMT0_SARHA Unreviewed; 655 AA.
AC G3VMT0;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Protein MTO1 homolog, mitochondrial {ECO:0000256|ARBA:ARBA00013407};
GN Name=MTO1 {ECO:0000313|Ensembl:ENSSHAP00000004485.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004485.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004485.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004485.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the 5-carboxymethylaminomethyl modification
CC (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
CC {ECO:0000256|ARBA:ARBA00002739}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the MnmG family.
CC {ECO:0000256|ARBA:ARBA00007653}.
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DR AlphaFoldDB; G3VMT0; -.
DR STRING; 9305.ENSSHAP00000004485; -.
DR Ensembl; ENSSHAT00000004531.2; ENSSHAP00000004485.2; ENSSHAG00000003944.2.
DR eggNOG; KOG2311; Eukaryota.
DR GeneTree; ENSGT00390000011297; -.
DR HOGENOM; CLU_007831_2_2_1; -.
DR OrthoDB; 5486689at2759; -.
DR TreeFam; TF354240; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.150.570; GidA associated domain, C-terminal subdomain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR049312; GIDA_C_N.
DR InterPro; IPR004416; MnmG.
DR InterPro; IPR002218; MnmG-rel.
DR InterPro; IPR020595; MnmG-rel_CS.
DR InterPro; IPR026904; MnmG_C.
DR InterPro; IPR047001; MnmG_C_subdom.
DR InterPro; IPR044920; MnmG_C_subdom_sf.
DR InterPro; IPR040131; MnmG_N.
DR NCBIfam; TIGR00136; gidA; 1.
DR PANTHER; PTHR11806; GLUCOSE INHIBITED DIVISION PROTEIN A; 1.
DR PANTHER; PTHR11806:SF0; PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01134; GIDA; 1.
DR Pfam; PF13932; GIDA_C; 1.
DR Pfam; PF21680; GIDA_C_1st; 1.
DR SMART; SM01228; GIDA_assoc_3; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 2.
DR PROSITE; PS01280; GIDA_1; 1.
DR PROSITE; PS01281; GIDA_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 549..622
FT /note="tRNA uridine 5-carboxymethylaminomethyl modification
FT enzyme C-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01228"
SQ SEQUENCE 655 AA; 72716 MW; D09D02407B46FB58 CRC64;
MGGPRTIGGV MGRVHGALRP RAPRHDVSKD GGPLQSLSTI RSPLTLSSCS APVTVLNRGD
FCPALTMLPL GHWSCRVAAR LSKQPLAISR SYGGPAGPHY DVEEILTTPL LTVKETAVED
LLLTEPDSDH PGKCRVSGVV LEDGSRVYAE SVVLTTGTFL RGMILIGLEA YPAGRLGDQS
SIGLAQTLEN LGFVVGRLKT GTPPRIAKDS INFSILNKHM PDNPSVPFSF LSEAVWLRPE
DQLPCYLTHT NSRVEQIVNE NIHLNTHVKE TTKGPRYCPS IESKVLRFPN RIHQVWLEPE
GMDSDLIYPQ GLSMTLPPNI QEQLITSIRG LEKAKIVQPG YGVQYDYLDP RQITPSLETH
LVQRLFFAGQ INGTTGYEEA AAQGIIAGIN ASLRVHGKPP FVVSRTEGYI GVLIDDLTTL
GTSEPYRMFT SRVEFRVSLR PDNADSRLTF RGYSETGCVS QQRYNRASLM KSSLEEGIAV
LKSLQFSSYK WKKMIPEAPV STIKSEPQSA LDILKYEEVD MAMLAKVLPE PLTKFAECQE
LMNRLKIEAT YELSLILQQK EIEEVRRDEA LQLPKDLDYL TIRDVSLSQE VREKLHSSRP
QTIGAASRIP GITPAAIVNL LRFVKTTKHK KESADKLSLN DQYLSKRDRL QKIEL
//
