ID G3VN99_SARHA Unreviewed; 827 AA.
AC G3VN99;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=BCAR3 adaptor protein, NSP family member {ECO:0000313|Ensembl:ENSSHAP00000004654.1};
GN Name=BCAR3 {ECO:0000313|Ensembl:ENSSHAP00000004654.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004654.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004654.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004654.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR RefSeq; XP_003769709.2; XM_003769661.2.
DR AlphaFoldDB; G3VN99; -.
DR STRING; 9305.ENSSHAP00000004654; -.
DR Ensembl; ENSSHAT00000004702.2; ENSSHAP00000004654.1; ENSSHAG00000004089.2.
DR eggNOG; ENOG502QPX3; Eukaryota.
DR GeneTree; ENSGT00940000154130; -.
DR InParanoid; G3VN99; -.
DR OMA; VLVWWQY; -.
DR OrthoDB; 2953960at2759; -.
DR TreeFam; TF323756; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:Ensembl.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 156..255
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 550..820
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 827 AA; 93354 MW; 786D609169701919 CRC64;
MMAAGKFASL PRNMQVNHQF PLASSMDLLS SKSPLTEPRS DAYQDVSIHG TLPRKKKGSV
PIRSSDAFSY MGTLPYSKTQ RQNPSLIQDV IEESPLQDWR GENSTFRDPH LLDPVMEYVK
FSKERHIMDR SPEKLLKKEL EEELQLSGED LRSHAWYHGR IPRQVSESLV QRDGDFLVRD
SLSSPGNFVL TCQWKNTAQH FKISKTVLRL NEAYCRIQYQ FDQESFDTIP GLVRCYVGNR
RPISQQSGAI IFQPINRTVP LRCLEERYGT SPTRSREYSL SEGKMETTKR LSLNMCNVPS
REQSLARGNL LRNKEKSGSQ PACLDHMQDK RSLSLKAHQS ESYLPIGSKL PLQSSGVDTS
PCPNSPVFRT GSEPTLSPTV VRRVSLEAQV PGEALRGSDS QLYPKPPPKP SKVPFFKPPP
SPSTWHNFEA NYCELNPAFP PGFCGTKQAL CPQSGCGEPP KTRENGALSF RNSGTNYLIL
DDDAPRPSRA LLAAQMEKGQ EGGGVFVTPF LETVSSFRPN DFESKLLPPE NKPLETSMLK
RAKELFTNND PKVIAKHMLK MDCKVARILE VSEEMKRIMG VSSGLELITL PYGHQLRLDI
IERHNTMAIG IAVDILGCTG SLEERAATLH KIIQVAVELK DSMGDLYAFS AIMKALEMPQ
ITRLEQTWTA LRHQYTQTAI LYEKQLKPFS KTLHEGKETI CVPQNKVTVP LLMPLVTLME
RQVVTFEGTD MWEKNDQSCE IMLSHLETAR FIAQAADMYR ANAESILEGF QADEEMNEIF
KTEFQMRLLW GSKGAQVNQT ERYEKFNQIL TALSRKLEPP PLKHAEL
//