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Database: UniProt
Entry: G3VN99_SARHA
LinkDB: G3VN99_SARHA
Original site: G3VN99_SARHA 
ID   G3VN99_SARHA            Unreviewed;       827 AA.
AC   G3VN99;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   24-JAN-2024, entry version 61.
DE   SubName: Full=BCAR3 adaptor protein, NSP family member {ECO:0000313|Ensembl:ENSSHAP00000004654.1};
GN   Name=BCAR3 {ECO:0000313|Ensembl:ENSSHAP00000004654.1};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004654.1, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000004654.1, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000004654.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
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DR   RefSeq; XP_003769709.2; XM_003769661.2.
DR   AlphaFoldDB; G3VN99; -.
DR   STRING; 9305.ENSSHAP00000004654; -.
DR   Ensembl; ENSSHAT00000004702.2; ENSSHAP00000004654.1; ENSSHAG00000004089.2.
DR   eggNOG; ENOG502QPX3; Eukaryota.
DR   GeneTree; ENSGT00940000154130; -.
DR   InParanoid; G3VN99; -.
DR   OMA; VLVWWQY; -.
DR   OrthoDB; 2953960at2759; -.
DR   TreeFam; TF323756; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR   GO; GO:0016020; C:membrane; IEA:Ensembl.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0019900; F:kinase binding; IEA:Ensembl.
DR   GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR   GO; GO:0086100; P:endothelin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0002089; P:lens morphogenesis in camera-type eye; IEA:Ensembl.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR   GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IEA:Ensembl.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   CDD; cd10337; SH2_BCAR3; 1.
DR   Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR023578; Ras_GEF_dom_sf.
DR   InterPro; IPR001895; RASGEF_cat_dom.
DR   InterPro; IPR036964; RASGEF_cat_dom_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR   PANTHER; PTHR14247:SF10; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3; 1.
DR   PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR   Pfam; PF00617; RasGEF; 1.
DR   Pfam; PF00017; SH2; 1.
DR   SMART; SM00147; RasGEF; 1.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF48366; Ras GEF; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50009; RASGEF_CAT; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          156..255
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   DOMAIN          550..820
FT                   /note="Ras-GEF"
FT                   /evidence="ECO:0000259|PROSITE:PS50009"
SQ   SEQUENCE   827 AA;  93354 MW;  786D609169701919 CRC64;
     MMAAGKFASL PRNMQVNHQF PLASSMDLLS SKSPLTEPRS DAYQDVSIHG TLPRKKKGSV
     PIRSSDAFSY MGTLPYSKTQ RQNPSLIQDV IEESPLQDWR GENSTFRDPH LLDPVMEYVK
     FSKERHIMDR SPEKLLKKEL EEELQLSGED LRSHAWYHGR IPRQVSESLV QRDGDFLVRD
     SLSSPGNFVL TCQWKNTAQH FKISKTVLRL NEAYCRIQYQ FDQESFDTIP GLVRCYVGNR
     RPISQQSGAI IFQPINRTVP LRCLEERYGT SPTRSREYSL SEGKMETTKR LSLNMCNVPS
     REQSLARGNL LRNKEKSGSQ PACLDHMQDK RSLSLKAHQS ESYLPIGSKL PLQSSGVDTS
     PCPNSPVFRT GSEPTLSPTV VRRVSLEAQV PGEALRGSDS QLYPKPPPKP SKVPFFKPPP
     SPSTWHNFEA NYCELNPAFP PGFCGTKQAL CPQSGCGEPP KTRENGALSF RNSGTNYLIL
     DDDAPRPSRA LLAAQMEKGQ EGGGVFVTPF LETVSSFRPN DFESKLLPPE NKPLETSMLK
     RAKELFTNND PKVIAKHMLK MDCKVARILE VSEEMKRIMG VSSGLELITL PYGHQLRLDI
     IERHNTMAIG IAVDILGCTG SLEERAATLH KIIQVAVELK DSMGDLYAFS AIMKALEMPQ
     ITRLEQTWTA LRHQYTQTAI LYEKQLKPFS KTLHEGKETI CVPQNKVTVP LLMPLVTLME
     RQVVTFEGTD MWEKNDQSCE IMLSHLETAR FIAQAADMYR ANAESILEGF QADEEMNEIF
     KTEFQMRLLW GSKGAQVNQT ERYEKFNQIL TALSRKLEPP PLKHAEL
//
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