ID G3VNE6_SARHA Unreviewed; 635 AA.
AC G3VNE6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE RecName: Full=PAS domain-containing protein {ECO:0000259|PROSITE:PS50112};
GN Name=HIF3A {ECO:0000313|Ensembl:ENSSHAP00000004701.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004701.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004701.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000004701.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3VNE6; -.
DR STRING; 9305.ENSSHAP00000004701; -.
DR Ensembl; ENSSHAT00000004749.2; ENSSHAP00000004701.2; ENSSHAG00000004128.2.
DR eggNOG; KOG3558; Eukaryota.
DR GeneTree; ENSGT00940000161745; -.
DR HOGENOM; CLU_010044_5_0_1; -.
DR InParanoid; G3VNE6; -.
DR TreeFam; TF317772; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR PANTHER; PTHR23043:SF18; HYPOXIA-INDUCIBLE FACTOR 3-ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 38..93
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 196..245
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 299..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 392..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 461..565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 612..635
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 510..532
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..635
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 635 AA; 68752 MW; F46516B361D8F94B CRC64;
MRLTISYLRM HRLCAAGDWS EVSAAGAGSG EPLDACYLKA LDGFVMVLTA EGDMAYLSEN
VSKHLGLSQL ELIGHSVFDF VHPCDQEELQ DVLTPRQGLS KKKMEAPTER SFSLRMKSTL
TSRGRTLNLK AATWKVLHCT GHMRAYSPPS ESSAGGAPGP EPPLRCLVLI CEAIPHPSSL
EPPLGRGAFL SRHTLDMKFT YCDERISEVA GYCPDDLIGC SAYEYIHALD SDAVSKSIHT
LLSKGQAVTG QYRFLARNGG YLWTQTQATV ISGGRGPQPE SVVCVHFVLS RVEETGVVLS
LEQTEQPTRR PPRPAERGPP SEKSPQGPGD GFDTPGPRIL AFLKPPALSE ATLAADPRRF
CSPDLRRLLA PILDGAAPAP AAAAPVTAAA AVPSGPSAKE RPRSPPPADL PNDLLLEMEN
VHKMFGFGKT LEAVETLDVE QDIEALELEM LAPYISMDDD FQLNTSDQPS RAFRRRPGAT
PRPRARSFHG LSPRPPETLP LLRWGSDPRL SQRTCPTEGD STDTSSQAGA RKRALPQSLE
EDSGTEALGV KPPKRSPSPT TDHFLLPPLS LSFLLSGEST PGTQSDPDTR LLDLEEPMAL
GSSSLLSFYE DEDTAQPRGH FQLEETLSQE LTPGT
//
