ID G3VNK1_SARHA Unreviewed; 272 AA.
AC G3VNK1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=PDCDL2 {ECO:0000313|EMBL:APS85789.1};
GN Name=PDCD1LG2 {ECO:0000313|Ensembl:ENSSHAP00000004756.2};
GN Synonyms=PDCDL2 {ECO:0000313|EMBL:APS85789.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000004756.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000004756.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|EMBL:APS85789.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=28018348; DOI=10.3389/fimmu.2016.00581;
RA Flies A.S., Lyons A.B., Corcoran L.M., Papenfuss A.T., Murphy J.M.,
RA Knowles G.W., Woods G.M., Hayball J.D.;
RT "PD-L1 Is Not Constitutively Expressed on Tasmanian Devil Facial Tumor
RT Cells but Is Strongly Upregulated in Response to IFN-? and Can Be Expressed
RT in the Tumor Microenvironment.";
RL Front. Immunol. 7:581-581(2016).
RN [3] {ECO:0000313|Ensembl:ENSSHAP00000004756.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KY075917; APS85789.1; -; mRNA.
DR RefSeq; XP_012399521.1; XM_012544067.1.
DR Ensembl; ENSSHAT00000004804.2; ENSSHAP00000004756.2; ENSSHAG00000004176.2.
DR GeneID; 100921234; -.
DR KEGG; shr:100921234; -.
DR CTD; 80380; -.
DR GeneTree; ENSGT00940000161373; -.
DR HOGENOM; CLU_013137_8_1_1; -.
DR OMA; ELYIVEH; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002682; P:regulation of immune system process; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR PANTHER; PTHR25466:SF1; PROGRAMMED CELL DEATH 1 LIGAND 2; 1.
DR PANTHER; PTHR25466; T-LYMPHOCYTE ACTIVATION ANTIGEN; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..272
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5041117370"
FT TRANSMEM 236..256
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..132
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 149..222
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 272 AA; 31217 MW; 01A7133279AE1656 CRC64;
MFFLLSFLIV EMKLHLTTGL FIVTVPKEFY MADYGSNITM ECNFDTGGEV DIEALRVTWA
KDERKIVNFP SKQEDLEIHS EPTGRRMTLL EDQLSLRKAL LHIRDVQIMD AGQYHCLLFY
RDAADYKYVT LQVKASYKTI NTQVIRVPGN NEMELTCQSQ GYPLAVVTWL NISESVNTTY
SKTPEGLYNI TSVLRLKANT HSNVSCEFWN EAIQESTSAV VNTSDQEKIP YRELPLVYIF
ISTCIIIFVA VFLIFLKLRH NSKVSRRTGV NL
//
