ID G3VT59_SARHA Unreviewed; 948 AA.
AC G3VT59;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=ERN2 {ECO:0000313|Ensembl:ENSSHAP00000006364.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006364.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000006364.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000006364.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004115}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004115}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3VT59; -.
DR STRING; 9305.ENSSHAP00000006364; -.
DR Ensembl; ENSSHAT00000006419.2; ENSSHAP00000006364.2; ENSSHAG00000005538.2.
DR eggNOG; KOG1027; Eukaryota.
DR GeneTree; ENSGT00940000160812; -.
DR HOGENOM; CLU_004875_1_1_1; -.
DR InParanoid; G3VT59; -.
DR TreeFam; TF313986; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:Ensembl.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0004521; F:RNA endonuclease activity; IEA:InterPro.
DR GO; GO:0030263; P:apoptotic chromosome condensation; IEA:Ensembl.
DR GO; GO:0030968; P:endoplasmic reticulum unfolded protein response; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0016075; P:rRNA catabolic process; IEA:Ensembl.
DR CDD; cd09769; Luminal_IRE1; 1.
DR CDD; cd10422; RNase_Ire1; 1.
DR CDD; cd13982; STKc_IRE1; 1.
DR Gene3D; 1.20.1440.180; KEN domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR045133; IRE1/2-like.
DR InterPro; IPR010513; KEN_dom.
DR InterPro; IPR038357; KEN_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR018391; PQQ_beta_propeller_repeat.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR011047; Quinoprotein_ADH-like_supfam.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13954; IRE1-RELATED; 1.
DR PANTHER; PTHR13954:SF15; SERINE_THREONINE-PROTEIN KINASE_ENDORIBONUCLEASE IRE2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF06479; Ribonuc_2-5A; 1.
DR SMART; SM00564; PQQ; 4.
DR SMART; SM00580; PUG; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50998; Quinoprotein alcohol dehydrogenase-like; 1.
DR PROSITE; PS51392; KEN; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..948
FT /note="non-specific serine/threonine protein kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029887867"
FT DOMAIN 539..800
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 803..931
FT /note="KEN"
FT /evidence="ECO:0000259|PROSITE:PS51392"
FT REGION 479..529
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 948 AA; 104319 MW; D068133BE1A989F7 CRC64;
MERAGLPLCL LALLWPCLPQ GRTGSIPEAL LFISTLDGSL HAVSKKTGDI QWTLKDDPII
QGPVYATEPA FLPDPSDGSL YILGEESKQG LMKLPFTIPE LVHASPCRSS DGVFYTGRKQ
DTWFMVDPKS GKKQTMLSTE AWDGLYPSAP LLYIGRTQYT VTMYDPRSQA LRWNTTYRGY
SAPLLDHLPG YQVGHFACSG EGLVVTVDKE NGTVLWTRDY GSPVAGIYAW HQDSLHRLPH
LTMALDTLRF LTLRSNHIRL RRWAQPPGTA NRDFSTSETQ LLLTLYVGKH AASFYASSAL
VHAGVALVPR GVTLAPVKGP TTEGVTLSDS GEREVTPSTA VRYPPGSITA LHSSWLLIGH
HELPPVLHTT MLRVFPSSES GTRAKISPSD GALPGPLFQE LLSLSQEVTW GLERLPEPQP
EQRPQDLYPG SGSRDILVAG LTTLLLGGWI IFLLCQCIQE KHYGPVGIPN PCPSQDLLPL
PPGAALNNQG TSWRSTAITP SSSDPKQPTC KVHSSQSAPE SGDTEAPDEE LTVVGKISFN
SKDVLGRGTG GTFVFRGQFE GRAVAVKRLL RECFSLVHRE VQLLQESDSH PGVLRYFCTE
RGPQFHYIAL ELCTATLKEY VENPALDHLG LEPVALLYQL TSGLAHLHSL NIVHRDLKPC
NILITAPNSQ GRSRAVLSDF GLCKKLPAGR HTFSLCSGIP GTEGWMAPEL LQDAPPQSPT
CAVDIFSAGL VFYYVLSGGG HPFGDSLHRQ ANILAGAVHM DHFEEETHEK VIAKELVEAM
LSPQPQLRPS AQSVLAHPFF WSRTKELQFF QDVSDRVEKE AAEGPLVTAL ETGGKVVVRQ
NWHSHISGPL QSDLRKFRTY KGTSVRDLLR AMRNKRHHYQ ELPTEVRQAL GQVPEEFVQY
FTSRFPQLLL HTHKAMGSCA SESLFQPYYS TEGMGDKKDK APDCRGNS
//
