ID G3VTA1_SARHA Unreviewed; 492 AA.
AC G3VTA1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=phosphatidylinositol N-acetylglucosaminyltransferase {ECO:0000256|ARBA:ARBA00012420};
DE EC=2.4.1.198 {ECO:0000256|ARBA:ARBA00012420};
DE AltName: Full=GlcNAc-PI synthesis protein {ECO:0000256|ARBA:ARBA00032160};
GN Name=PIGA {ECO:0000313|Ensembl:ENSSHAP00000006406.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006406.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000006406.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000006406.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
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DR RefSeq; XP_003765609.1; XM_003765561.2.
DR AlphaFoldDB; G3VTA1; -.
DR STRING; 9305.ENSSHAP00000006406; -.
DR Ensembl; ENSSHAT00000006461.2; ENSSHAP00000006406.1; ENSSHAG00000005576.2.
DR GeneID; 100918629; -.
DR KEGG; shr:100918629; -.
DR CTD; 5277; -.
DR eggNOG; KOG1111; Eukaryota.
DR GeneTree; ENSGT00390000014405; -.
DR HOGENOM; CLU_009583_19_0_1; -.
DR InParanoid; G3VTA1; -.
DR OMA; QCVLPTM; -.
DR OrthoDB; 24420at2759; -.
DR TreeFam; TF105675; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0000506; C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; IEA:Ensembl.
DR GO; GO:0017176; F:phosphatidylinositol N-acetylglucosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEA:Ensembl.
DR GO; GO:0006506; P:GPI anchor biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd03796; GT4_PIG-A-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR001296; Glyco_trans_1.
DR InterPro; IPR039507; PIG-A/GPI3.
DR InterPro; IPR013234; PIGA_GPI_anchor_biosynthesis.
DR PANTHER; PTHR45871; N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN; 1.
DR PANTHER; PTHR45871:SF1; PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A; 1.
DR Pfam; PF00534; Glycos_transf_1; 1.
DR Pfam; PF08288; PIGA; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 4: Predicted;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 429..450
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 79..168
FT /note="PIGA GPI anchor biosynthesis"
FT /evidence="ECO:0000259|Pfam:PF08288"
FT DOMAIN 229..373
FT /note="Glycosyl transferase family 1"
FT /evidence="ECO:0000259|Pfam:PF00534"
SQ SEQUENCE 492 AA; 55410 MW; 91FF2419479FB020 CRC64;
MTKLHLNMAY RRVNGNGHSI TSKLSHNDYG IHQLHRTGTH NICMVSDFFY PNMGGVESHI
YQLSQCLIER GHKVIIVTHA YGNRKGIRYL TNGLKVYYLP LKVMYNQSTA TTLFHSLPLL
RYIFVRERVT IVHSHSSFSA MAHDALFHAK TMGLQTVFTD HSLFGFADVS SVLTNKLLTV
SLCDTNHIIC VSYTSKENTV LRAALNPEIV SVIPNAVDPT DFTPDPFRRD DSVITIVVIS
RLVYRKGIDL LSGIIPELCQ KYPDLNFIVG GEGPKRIILE EVRERYQLHD RVRLLGALEH
QDVRDVLVQG HIFLNTSLTE AFCMAIVEAA SCGLRVVSTR VGGIPEVLPD NLIILCEPSV
KSLCNGLEKA ISQLKSGTLP DPEKIHNRVK TFYTWRNVAE RTEKVYDRVS REAVLPMDKR
LNRLISHCGP VTGCTFALLA VLNFLFLVFL RWLTPDSIID IAVDATGPKG AWTQQYSFCK
KGEENKEISE SR
//
