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Database: UniProt
Entry: G3VTH6_SARHA
LinkDB: G3VTH6_SARHA
Original site: G3VTH6_SARHA 
ID   G3VTH6_SARHA            Unreviewed;      2397 AA.
AC   G3VTH6;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   25-OCT-2017, entry version 40.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSSHAP00000006481};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000006481, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000006481}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000006481}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000006481}.
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DR   EMBL; AEFK01179643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01179644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01179645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01179646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01179647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01179648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000006481; -.
DR   Ensembl; ENSSHAT00000006537; ENSSHAP00000006481; ENSSHAG00000005640.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G3VTH6; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0010045; P:response to nickel cation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    123    142       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    213    237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    345    366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    372    397       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    748    766       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    778    799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    869    888       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    945    968       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1278   1296       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1316   1337       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1349   1368       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1413   1435       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1515   1538       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1613   1634       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1646   1669       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1747   1766       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1830   1852       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       80    408       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      747    974       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1276   1548       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1612   1862       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1547   1574       {ECO:0000256|SAM:Coils}.
FT   COILED     1851   1875       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2397 AA;  265914 MW;  4BAB1DA05FD97BB5 CRC64;
     MDEEEDGAKA EEFGQSKTLV RLNDLSGAGG LLGPGPGDKD PGSTDSEPEG LPYPALAPVV
     FFYLSQESRP RSWCLRLVCN PWFERVSMLV ILLNCVTLGM FQPCEDIACD SQRCRILQAF
     DDFIFAFFAV EMVVKMVALG IFGKKCYLGD TWNRLDFFIV IAGMLEYSLD LQNVSFSAVR
     TVRVLRPLRA INRVPTTVSP LIQLKVIQAS QPVVGTVGML CFFVFFIFGI VGVQLWAGLL
     RNRCFLPENF SIPLSVDLER YYQTENEDES PFICSQPREN GMRSCRSVPT LRGEGGGGPP
     CGLDYEAYNS SSNTTCVNWN QYYTNCSAGE HNPFKGAINF DNIGYAWIAI FQVITLEGWV
     DIMYFVMDAH SFYNFIYFIL LIIVGSFFMI NLCLVVIATQ FSETKQRESQ LMKEQRVRFL
     SNASTLASFS EPGSCYEELL KYLVYILRKA ARRLAQASRV VGARAGLLAS PAGRGVSETQ
     PSGSGSCSRS RRRRPSIHHL VHHHHHHHHH YHLGNGTLRA PHANPEISDG DASETRRLML
     PAPPTSAHPG GSPGGSESVH SFYHADCHLE PLRCQASPAR SSPEGPGRNM GGGKVYPTVH
     SRSPPKVLKE KALVEAAPTS GPPTLTNLNI PPGPYSSMHK LLETQSTGSC QGSCRISSPC
     GKAESGDSGP DNCPYCTPTQ AGEAELMDPE LHDSDSEGIY EFTQDAQHGD HRDPHWGPSQ
     GQGQEPSPLM AFWTLVCETF RKIVDSKYFG RGIMIAILIN TLSMGIEYHE QPEELTNALE
     ISNIVFTSLF ALEMLLKLLV YGPFGYIKNP YNIFDGVIVV ISVWEIVGQQ GGGLSVLRTF
     RLMRVLKLVR FLPALQRQLV VLMKTMDNVA TFCMLLMLFI FIFSILGMHL FGCKFASERD
     GDTLPDRKNF DSLLWAIVTV FQILTQEDWN KVLYNGMAST SSWAALYFIA LMTFGNYVLF
     NLLVAILVEG FQTEEISKRE DAGGQLSCIQ LPVDSLGGDA TKSESETDFF SPSLDGKGDR
     KKHLALMSLG EHPELRKSLL PPLIIHTAAT PMPLPKSVGL GEASGPASRR PSGSGSNDPN
     VAHEIKSPPS VRSSPHSPWS AASSWNSRRS SWNSLGRAPS LKRRSPSGER RSLLSGDGRE
     SMEEDETSDE DQASRVGSDP RAGSVDRETK GSFDLQDTLQ VPGVYRTASG QSSASEHQDC
     NGKTASGHPD RNLQLDEPQL EGDDADDEGN MSKGERFRAW IRSWLPTCCR ERDTWSAYIF
     PPQSKFRLMC HKIITHKMFD HVVLVIIFLN CITIAMERPK IDPHSAERIF LTLSNYIFTA
     IFLAEMTVKV VALGWCFGEK AYLRSSWNIL DGLLVLISVI DILVSMVSDS GTKILGMLRV
     LRLLRTLRPL RVISRAQGLK LVVETLMSSL KPIGNIVVIC CAFFIIFGIL GVQLFKGKFF
     ICQGEDTRNI TNKSDCTEAS YRWVRHKYNF DNLGQALMSL FVLASKDGWV DIMYDGLDAV
     GVDQQPIMNH NPWMLLYFIS FLLIVAFFVL NMFVGVVVEN FHKCRQHQEE EEARRREEKR
     LRRMEKKRRN LMLDDVITPG SSASAAPEAQ CKPYYSDYSR FRLLVHHMCT SHYLDLFITG
     VIGLNVVTMA MEHYQQPQIL DEALKICNYI FTVIFVLESV FKLVAFGFRR FFQDRWNQLD
     LAIVLLSIMG ITLEEIEVNA SLPINPTIIR IMRVLRIARV LKLLKMAVGM RALLDTVMQA
     LPQVGNLGLL FMLLFFIFAA LGVELFGDLE CDETHPCEGL GRHATFRNFG MAFLTLFRVS
     TGDNWNGIMK DTLRDCDQES TCYNTVISPI YFVSFVLTAQ FVLVNVVIAV LMKHLEESNK
     EAKEEAELEA ELEMEMKTLA PSQPPMPGDP FSWPRGEGGS DSQPGSPKLR APQALHVKVA
     SQLSLTHPTD RQLFDTISLL IQGSLEGELK LMDELSSSLG RPYTFPPAPG QGDSEPQIPL
     AEMEALSLTS DILSEQSCSL ALTDDSLPDD THILLLSALE RNTVTLPYPE GILATGPSAF
     QPSLLTIRKS GVSRTHSLPN DSYMFRDGGS YQGSVGQRAW MLPKSQSAGS TTSIHSQPVD
     ARALLQLPKD GSHQLQLYDL SSWGMIPKLP PPGCSPSAQR QLRRQAAIRT DSVDMQFVGS
     REDVVAEVSV SPTMAPQDTP SWGRSSIRVQ QCPRNQCRKS KHTPPAPCLM REAPLQDRCQ
     PGHEASETIS CLELHAQPSW GSSPGPQHPP TQKGGEHLRD LKKCYSAETQ GCPRRPTLWP
     DEQRRHSIAV SSLDSCSQTC PGPGALSLGG QELNRPGIGS KSWPKKKLSP PCISIEPPDS
     QGPRPLPNPG VCLRRRSPST DSKDPLAPDS MAISSPPPKK DLLMLSSFSS DQLDLEP
//
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