ID G3VVT2_SARHA Unreviewed; 1676 AA.
AC G3VVT2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Polybromo 1 {ECO:0000313|Ensembl:ENSSHAP00000007287.2};
GN Name=PBRM1 {ECO:0000313|Ensembl:ENSSHAP00000007287.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000007287.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000007287.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000007287.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR STRING; 9305.ENSSHAP00000007287; -.
DR Ensembl; ENSSHAT00000007349.2; ENSSHAP00000007287.2; ENSSHAG00000006335.2.
DR eggNOG; KOG1827; Eukaryota.
DR GeneTree; ENSGT00390000003017; -.
DR HOGENOM; CLU_001483_1_0_1; -.
DR TreeFam; TF106120; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016586; C:RSC-type complex; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006338; P:chromatin remodeling; IEA:InterPro.
DR CDD; cd04717; BAH_polybromo; 2.
DR CDD; cd05524; Bromo_polybromo_I; 1.
DR CDD; cd05517; Bromo_polybromo_II; 1.
DR CDD; cd05520; Bromo_polybromo_III; 1.
DR CDD; cd05518; Bromo_polybromo_IV; 1.
DR CDD; cd05515; Bromo_polybromo_V; 1.
DR CDD; cd05526; Bromo_polybromo_VI; 1.
DR CDD; cd21984; HMG-box_PB1; 1.
DR Gene3D; 2.30.30.490; -; 2.
DR Gene3D; 1.20.920.10; Bromodomain-like; 6.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR001487; Bromodomain.
DR InterPro; IPR036427; Bromodomain-like_sf.
DR InterPro; IPR018359; Bromodomain_CS.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR037968; PBRM1_BD5.
DR InterPro; IPR037382; Rsc/polybromo.
DR PANTHER; PTHR16062:SF19; PROTEIN POLYBROMO-1; 1.
DR PANTHER; PTHR16062; SWI/SNF-RELATED; 1.
DR Pfam; PF01426; BAH; 2.
DR Pfam; PF00439; Bromodomain; 6.
DR Pfam; PF00505; HMG_box; 1.
DR PRINTS; PR00503; BROMODOMAIN.
DR SMART; SM00439; BAH; 2.
DR SMART; SM00297; BROMO; 6.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47370; Bromodomain; 6.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS51038; BAH; 2.
DR PROSITE; PS00633; BROMODOMAIN_1; 5.
DR PROSITE; PS50014; BROMODOMAIN_2; 6.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Bromodomain {ECO:0000256|ARBA:ARBA00023117, ECO:0000256|PROSITE-
KW ProRule:PRU00035}; DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 82..152
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 218..288
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 386..456
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 524..594
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 662..732
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 803..848
FT /note="Bromo"
FT /evidence="ECO:0000259|PROSITE:PS50014"
FT DOMAIN 942..1060
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1143..1259
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT DOMAIN 1366..1434
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 1366..1434
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 17..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 172..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 473..503
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1339..1365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 23..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..625
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 888..919
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1676 AA; 191633 MW; 25C394BE7B99C335 CRC64;
MRRLAFRGAG CTLKKLDSMG SKRRRATSPS SSISGDFDDG HHSVPTPGPS RKRRRLSNLP
TVDPIAVCHE LYNTIRDYKD EQGRLLCELF IRAPKRRNQP DYYEVVSQPI DLMKIQQKLK
MEEYDDVNLL TADFQLLFNN AKAYYKPDSP EFKAACKLWD LYLRTRNEFV QKGDADEDED
EEDGHDNQGT MSEVSSPSYL KEILEQLLEA IAIATNPSGR LISELFQKLP SKVQYPDYYA
IIKEPIDLKT IAQKIQNGSY KSIHAMAKDI DLLAKNAKTY NEPGSQVFKD ANSIKKIFHL
KKAEIEHVEM AKSSLRISNK RAVQGGRLSA ITMALQYGSE SDEDAALAAA RYEEGESEAE
SITSFMDVSN PLYQLYDTVR SCRNNQGQLI AEPFFHLPSK KKYPDYYQQI KMPISLQQIR
TKLKNQEYET LDHLECDLNL MFENAKRYNV PNSAIYKRVL KMQQVMQAKK KELARRDDIE
DGDSMISSAT SDTGSAKRKS KKNIRKQRMK ILFNVVLEAR EPGTGRRLCD LFMVKPSKKD
YPDYYKIILE PMDLKIIEHN IRNDKYAGEE AMMEDMKLMF RNARHYNEEG SQVYNDAHIL
EKMLRDKRKE LGPLPEDDDM ASPKLKLSRK SGISPKKSKY MTPMQQKLNE VYEAVKNYTD
KRGRRLSAIF LRLPSRSELP DYYLTIKKPV DMEKIRSHMM ANKYQDIDSM VEDFVMMFNN
ACTYNEPESL IYKDALVLHK VLLETRRDIE GDEDSHVPNV TLLIQELIHN LFVSVMSHQD
DEGRCYSDSL AEIPSVDPSF PNKPPLTFDI IRKNVENNRY RRLDLFQEQM FDVLERARRM
NRTDSEIYED AVELQQFFIK IRDELCKNGE ILLSPALSYT TKHLHNDVEK EKKEKLPKEI
EEDKLKREEE KREAEKSEDS SGGTGLSILH RTYSQDCSFK NSMYHVGDYV YVEPAEANLQ
PHIVCIERLW EDSAGEKWLC GCWFYRPNET FHLATRKFLE KEVFKSDYYN KVPVSKILGK
CVVMFVKEYF KLCPETFRDE DVYVCESRYS AKTKSFKKIK LWTMPVSSVR FIPRDVPLPV
VRVASVFANT DKLDDEKHTE TLEDSKGADT FLNLEKEKED VPVEMSNGEP GCHYFEQLRY
NDMWLKVGDC VFIKSHGLVR PRVGRIEKLW VRDGAAYFFG PIFIHPEETE HEPTKMFYKK
EVFLSNLEET CPMTCILGKC AVLSFKDFLS CRPTEIPEND VLLCESRYNE SDKQMKKFKG
LKRFSLSAKV VDDEIYYFRK PIVPQKEPSP LLEKKIQLLE AKFAELEGGD DDIEEMGEEE
GEVIEAPSLP QLQTPLANDL DIMPYTPPQS TPKSAKGSSK KEGSKRKINM SGYILFSSEM
RAVIKAQHPD YSFGELSRLV GTEWRNLETT KKAEYEERAA KVAEQQERER AAQQPQPSAS
PRAGPPAGAL MGVVPPPTPM AMLNQQLTPV AGMIGGYPPV LPPLQGPVDG IVSMGSMQPL
HPGVPPPHHL PPGMPGIPGI PPPGVMGQGV SPIVGPPAPG GSPYGQQMGI LGPPGQQAPP
PYPGQNPAGQ PVMQQPTTPM FVSPPPKTQR LLHSEAYLKY IEGLSAESNS ISKWDQTLAA
RRRDVHLSKE QESRLPSHWL KSKGAHTTMA DALWRLRDLM LRDTLNIRQA YNIENV
//
