ID G3VXT1_SARHA Unreviewed; 439 AA.
AC G3VXT1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Keratin, type I cytoskeletal 17 {ECO:0000256|ARBA:ARBA00040323};
DE AltName: Full=Cytokeratin-17 {ECO:0000256|ARBA:ARBA00041709};
DE AltName: Full=Keratin-17 {ECO:0000256|ARBA:ARBA00042488};
GN Name=KRT17 {ECO:0000313|Ensembl:ENSSHAP00000007986.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000007986.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000007986.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000007986.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_003768262.1; XM_003768214.2.
DR AlphaFoldDB; G3VXT1; -.
DR STRING; 9305.ENSSHAP00000007986; -.
DR Ensembl; ENSSHAT00000008050.2; ENSSHAP00000007986.2; ENSSHAG00000006929.2.
DR GeneID; 100924226; -.
DR KEGG; shr:100924226; -.
DR CTD; 3872; -.
DR eggNOG; ENOG502QTM6; Eukaryota.
DR GeneTree; ENSGT00940000160681; -.
DR HOGENOM; CLU_012560_8_1_1; -.
DR InParanoid; G3VXT1; -.
DR TreeFam; TF332742; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0031069; P:hair follicle morphogenesis; IEA:Ensembl.
DR GO; GO:0045109; P:intermediate filament organization; IEA:Ensembl.
DR GO; GO:0031424; P:keratinization; IEA:Ensembl.
DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl.
DR GO; GO:0051798; P:positive regulation of hair follicle development; IEA:Ensembl.
DR GO; GO:0045727; P:positive regulation of translation; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF180; KERATIN, TYPE I CYTOSKELETAL 17; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF46579; Prefoldin; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 90..401
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 94..128
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 193..234
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 259..386
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 439 AA; 48599 MW; 506B517B5B525056 CRC64;
MATTTTIRQY TTSSSIKGSS GLGGGSSRAS CRAPGSSFGS VSSSRLVSGG GLGGGYGGSC
YSGNYSFGSG LGGSYGSSFG SVDGLLAGGE KATMQNLNDR LASYLDKVRA LEEANTDLEL
KIRDWYQKQA PGPAKDYSGY YQTIEDLKNK ILTATVDNAN ILLQIDNARL AADDFRTKYE
TELALRTSVE ADINGLRRVL DELTLSRADL EMQIENLKEE LAYLKKNHDE EMNALRGQVS
GEINVEMDAA PGVDLSRTLA EMRDQYEKMA EKNRKDAEDW FFSKTEELNR EVATNSELLQ
SGKSEISELR RSVQALEIEL QSQLSMKASL EGSLAETESR YCVQLSQIQG LISSVEEQLA
QLRCEMEQQN QEYKVLLDVK TRLEQEIATY RRLLEGEDAH LSQYKPKEPM TTRQVRTIVE
EVQDGKVISS REQVHQSTR
//
