ID G3VYF8_SARHA Unreviewed; 617 AA.
AC G3VYF8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=SRY-box transcription factor 13 {ECO:0000313|Ensembl:ENSSHAP00000008213.1};
GN Name=SOX13 {ECO:0000313|Ensembl:ENSSHAP00000008213.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000008213.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000008213.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000008213.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003767655.1; XM_003767607.2.
DR AlphaFoldDB; G3VYF8; -.
DR STRING; 9305.ENSSHAP00000008213; -.
DR Ensembl; ENSSHAT00000008280.2; ENSSHAP00000008213.1; ENSSHAG00000007118.2.
DR GeneID; 100929833; -.
DR KEGG; shr:100929833; -.
DR CTD; 9580; -.
DR eggNOG; KOG0528; Eukaryota.
DR GeneTree; ENSGT00940000158759; -.
DR HOGENOM; CLU_018522_1_1_1; -.
DR InParanoid; G3VYF8; -.
DR OMA; MEETPGH; -.
DR OrthoDB; 2902801at2759; -.
DR TreeFam; TF320471; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0042492; P:gamma-delta T cell differentiation; IEA:Ensembl.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0090336; P:positive regulation of brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IEA:Ensembl.
DR GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IEA:Ensembl.
DR CDD; cd22030; HMG-box_SoxD; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR45789; FI18025P1; 1.
DR PANTHER; PTHR45789:SF4; TRANSCRIPTION FACTOR SOX-13; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; HMG-box; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 419..487
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 419..487
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 32..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 596..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 176..213
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 278..312
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 68902 MW; 47037F259E53B107 CRC64;
MSMRSPISPQ LALDGIGTMV NCTVKAEEKK DICQEAPSGQ QVPAPAAEPL TGDPARPPQD
GADSSGPPQD CGSPRSDGPP EPRRSGPELA TGSQEKLDFN RNLKEVMPTI EKLLSSDWRE
RLLGRSTVET KDVKGTQESL AEKELQLLVM IHQLSTLRDQ LLTAHSEQKN MAAMLFEKQQ
QQMELARQQQ EQIAKQQQQL IQQQHKINLL QQQIQQVNMP YVMIPAFPPS HQPMPVTPDS
QLALPIQPIP CKPVEYPLQL LHSPSTPAVK RPGAVSTHHP LQESSQPLNL TAKPKGPELP
NTSSSPNLKI SSCGPLPANH GAPTRDLQAS PPSLPLGFLG EGDAITKAIQ DARQLLHGHS
APMESSPNAS FRKDLINLES SPAKDRLEES CGHQLDETIL SCDMDGSRHF PESRNNNHIK
RPMNAFMVWA KDERRKILQA CPDMHNSSIS KILGSRWKSM TNQEKQPYYE EQARLSRQHL
EKYPDYKYKP RPKRTCIVEG KRLRVGEYKA LMRNRRQDAR QNYVIPPPGN QMQMSSPDVL
YPRAPGMPLA QPLLEHYVPR SLDPSMPIIV NTRSLKEENE GAEDGHSVAD GEMFRYSEEE
DSEVEEKSDG ELVVLTD
//
