ID   G3W1V2_SARHA            Unreviewed;       886 AA.
AC   G3W1V2;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-MAR-2024, entry version 59.
DE   RecName: Full=Tetratricopeptide repeat protein 27 {ECO:0000256|ARBA:ARBA00024124};
GN   Name=TTC27 {ECO:0000313|Ensembl:ENSSHAP00000009407.1};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009407.1, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000009407.1, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000009407.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC27 family.
CC       {ECO:0000256|ARBA:ARBA00024020}.
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DR   AlphaFoldDB; G3W1V2; -.
DR   STRING; 9305.ENSSHAP00000009407; -.
DR   Ensembl; ENSSHAT00000009488.2; ENSSHAP00000009407.1; ENSSHAG00000008140.2.
DR   eggNOG; KOG1128; Eukaryota.
DR   GeneTree; ENSGT00500000044929; -.
DR   HOGENOM; CLU_004905_2_0_1; -.
DR   InParanoid; G3W1V2; -.
DR   OMA; NNRYARA; -.
DR   OrthoDB; 23605at2759; -.
DR   TreeFam; TF105894; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR044244; TTC27/Emw1.
DR   PANTHER; PTHR16193:SF0; TETRATRICOPEPTIDE REPEAT PROTEIN 27; 1.
DR   PANTHER; PTHR16193; UNCHARACTERIZED; 1.
DR   Pfam; PF13431; TPR_17; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 4.
DR   SUPFAM; SSF48452; TPR-like; 1.
DR   PROSITE; PS50005; TPR; 3.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          570..603
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          604..637
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          638..671
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          1..39
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..19
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   886 AA;  101505 MW;  048CAD120C8BFA49 CRC64;
     MLPGTRFSTW NSSSPAELES GRPWVSPPEQ PPRSPWSVPG SGVAMWPPEL ALLRGFPTHV
     EQQRWKQVEE AGAESGSFLQ LMLEGNYEAI FLNTVIQNIF TASILKEEKI DSYLEKQILS
     FLDCSDLYET ERQQMIFLLG VSSLQLFVQS NWTGPPVDLQ PQDFLPPVLL QQFTETKELC
     TIVLSLLVLD GESIYSLTSH PVLLLLARII LVNLRHKFPS IQTLPWWTLR CVNIHQQLLE
     ERSPELFSLA QTSIEQVMKL ENLLTKETCG YLNVQFHLEC AHTYLYYYEY AKAKDQFNIA
     KDITKLKIDL TGALGKRTRF QENYVAQLIL DVQRGEDNFP HNELSPAPTP LENLTKNLEL
     NDDTVLNEIK LADCEQYQMP DLCAEELAVV LGVCTNFQKT NPVHKLTEEE LLAFTSCLLS
     QPKFWAIQTT ALILRTKLEK GSTRRVERAM MQTQALADQF EDKNTSILER LKIFYCCQVP
     TRWAIQRQLA TLLFELGCTS SALQIFEKLE MWEDVVICHE RAGHHGKAEE ILRQELEKKE
     TPSLYCLLGD VLRDHHYYDK AWELSNHRSA RAQRSKGLLH LRNKEFKECV ECFERSVKIN
     PMQLGVWFSL GCAYIALEDW GGSAKAFQRC VTLEPDNAEA WNNLSTAYIR LKQKIKAFRT
     LQEALKCNYE HWQIWENYIL TSTDVGEFSE AIKAYHRLMD LRDKYKDVQV LKILVRAVTD
     GMTDRSGDIA TGLKGKLQEL FGRVTSRVTN DGEIWRLYAQ IYGNGQSDNP DENEKVLQYL
     TKAYKCDTHS NSWEKDIASF KEIVKGAVEL AHVALHCSKN KSDPQEAVQI LSSARLNLRG
     LSSKAKQLFV DLASGEISPE LAEEMTTMDI LITELQDMSN QLRNQY
//