ID G3W225_SARHA Unreviewed; 1015 AA.
AC G3W225;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Ubiquitin like modifier activating enzyme 6 {ECO:0000313|Ensembl:ENSSHAP00000009480.2};
GN Name=UBA6 {ECO:0000313|Ensembl:ENSSHAP00000009480.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009480.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009480.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009480.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ubiquitin-activating E1 family.
CC {ECO:0000256|ARBA:ARBA00005673}.
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DR AlphaFoldDB; G3W225; -.
DR STRING; 9305.ENSSHAP00000009480; -.
DR Ensembl; ENSSHAT00000009563.2; ENSSHAP00000009480.2; ENSSHAG00000008202.2.
DR eggNOG; KOG2012; Eukaryota.
DR GeneTree; ENSGT00940000158826; -.
DR HOGENOM; CLU_002556_0_0_1; -.
DR InParanoid; G3W225; -.
DR TreeFam; TF300586; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0019780; F:FAT10 activating enzyme activity; IEA:Ensembl.
DR GO; GO:0004839; F:ubiquitin activating enzyme activity; IEA:Ensembl.
DR GO; GO:0021764; P:amygdala development; IEA:Ensembl.
DR GO; GO:0060996; P:dendritic spine development; IEA:Ensembl.
DR GO; GO:0021766; P:hippocampus development; IEA:Ensembl.
DR GO; GO:0007612; P:learning; IEA:Ensembl.
DR GO; GO:0007626; P:locomotory behavior; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR CDD; cd01491; Ube1_repeat1; 1.
DR CDD; cd01490; Ube1_repeat2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 2.40.30.180; Ubiquitin-activating enzyme E1, FCCH domain; 1.
DR Gene3D; 3.50.50.80; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1; 1.
DR Gene3D; 3.40.50.12550; Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2; 1.
DR Gene3D; 1.10.10.2660; Ubiquitin-activating enzyme E1, SCCH domain; 1.
DR Gene3D; 3.10.290.60; Ubiquitin-activating enzyme E1, UFD domain; 1.
DR InterPro; IPR032420; E1_4HB.
DR InterPro; IPR032418; E1_FCCH.
DR InterPro; IPR042302; E1_FCCH_sf.
DR InterPro; IPR045886; ThiF/MoeB/HesA.
DR InterPro; IPR000594; ThiF_NAD_FAD-bd.
DR InterPro; IPR018965; Ub-activating_enz_E1_C.
DR InterPro; IPR042449; Ub-E1_IAD_1.
DR InterPro; IPR038252; UBA_E1_C_sf.
DR InterPro; IPR019572; UBA_E1_SCCH.
DR InterPro; IPR042063; Ubi_acti_E1_SCCH.
DR InterPro; IPR035985; Ubiquitin-activating_enz.
DR InterPro; IPR018075; UBQ-activ_enz_E1.
DR InterPro; IPR000011; UBQ/SUMO-activ_enz_E1-like.
DR NCBIfam; TIGR01408; Ube1; 1.
DR PANTHER; PTHR10953; UBIQUITIN-ACTIVATING ENZYME E1; 1.
DR PANTHER; PTHR10953:SF186; UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 6; 1.
DR Pfam; PF16191; E1_4HB; 1.
DR Pfam; PF16190; E1_FCCH; 1.
DR Pfam; PF09358; E1_UFD; 1.
DR Pfam; PF00899; ThiF; 2.
DR Pfam; PF10585; UBA_E1_SCCH; 1.
DR PRINTS; PR01849; UBIQUITINACT.
DR SMART; SM00985; UBA_e1_C; 1.
DR SUPFAM; SSF69572; Activating enzymes of the ubiquitin-like proteins; 2.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 885..1007
FT /note="Ubiquitin-activating enzyme E1 C-terminal"
FT /evidence="ECO:0000259|SMART:SM00985"
SQ SEQUENCE 1015 AA; 114260 MW; 5466BD2A35AF9D57 CRC64;
MEIDDALYSR QRYVLGDSAM QKMARSHVFL SGMGGLGVEI AKNVVLAGIK ALTIHDTKQC
QAWDLGTNFF ICEDDVINRR NRAEAVIHHV AELNPYVHVT SSSVSLDETT DLSFLKQYQC
IVLTEIRLPL QKKINDFCRA QHPPIKFISA DVFGIWSRLF CDFGEEFEVL DTSGEEPKEI
FISNITQANP GIVTCLENHP HRLETGNFVT FREINGMTGL NGFAKQITVV SPFSFSIGDT
TEMEPYLHGG IAVQVKTSQT FCFECLEKQI KHPTCLIADF SKPEAPLQIH AAMLALDQFQ
ENYNRKPNIG CRQDSEELLK LATSISATLQ EKPEVNVNIV NWLSWTAQGF LAPLAAAIGG
VASQEVLKAV TGKFSPLCQW LYIEAADLFE SLDKSNCEEF LPRGDRYDAL RACIGDTLCQ
KLQNLNIFLV GCGAIGCEML KNFALLGIGT GKEKGMVTIT DPDLIEKSNL NRQFLFRPHH
IQKPKSYTAA AATLSINPQL KIESHLHKVC PATEMIYSDE FYTKQDIIVT ALDNVEARRY
VDSRCLANLR PLLDSGTMGT KGHTEAIIPH LTESYNSHRD PPEEEIPFCT LKSFPAAIEH
TIQWARDKFE SSFSHKPSLF NKFWQTYSSA EEVLQRIQSG ESLEGCFQVI KSLSRRPRNW
SHCVELARMK FEKYFNHKAL QLLHCFPLDT RLKDGSLFWQ SPKRPPSPIK FEFNDPLHFS
FIQTAAKLFA TIYCIPFTEK DLSVEVFSNI LSKLDIPEFK PSNKVVQTDE TARKPDHVPV
SSEDERNAVF QLEKAISSSE ATKNDLQMVV LSFEKDDDSN GHIDFITAAS NLRAKMYNIE
PADRLKTKRI AGKIIPAIAT STAAVSGLVA LELIKIAGGL PFEAYRNCFL NLAIPIIVFT
ETAEVKKIEI RNGITFTIWD RWTIHGKEDF TLSDFINAVR EKYGIEPTMV VQGVKMLYVP
VMPGHIKRLK LTMHKLVKPS SEKKYVDLTV SFAPENDGDE DLPGPPVRYY FSQDD
//