ID G3W2R2_SARHA Unreviewed; 823 AA.
AC G3W2R2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Unk like zinc finger {ECO:0000313|Ensembl:ENSSHAP00000009717.2};
GN Name=UNKL {ECO:0000313|Ensembl:ENSSHAP00000009717.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009717.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009717.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009717.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the unkempt family.
CC {ECO:0000256|ARBA:ARBA00008808}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; G3W2R2; -.
DR STRING; 9305.ENSSHAP00000009717; -.
DR Ensembl; ENSSHAT00000009802.2; ENSSHAP00000009717.2; ENSSHAG00000008411.2.
DR eggNOG; KOG1100; Eukaryota.
DR eggNOG; KOG1595; Eukaryota.
DR GeneTree; ENSGT00940000158822; -.
DR HOGENOM; CLU_014526_1_0_1; -.
DR InParanoid; G3W2R2; -.
DR TreeFam; TF314982; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd16772; RING-HC_UNKL; 1.
DR Gene3D; 4.10.1000.10; Zinc finger, CCCH-type; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045234; Unkempt-like.
DR InterPro; IPR040594; Unkempt_Znf.
DR InterPro; IPR000571; Znf_CCCH.
DR InterPro; IPR036855; Znf_CCCH_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14493:SF37; E3 UBIQUITIN-PROTEIN LIGASE UNKL-RELATED; 1.
DR PANTHER; PTHR14493; UNKEMPT FAMILY MEMBER; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR Pfam; PF00642; zf-CCCH; 1.
DR Pfam; PF18384; zf_CCCH_5; 1.
DR SMART; SM00356; ZnF_C3H1; 4.
DR SUPFAM; SSF90229; CCCH zinc finger; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50103; ZF_C3H1; 4.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 77..106
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 117..147
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 245..279
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 287..315
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT DOMAIN 782..817
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT ZN_FING 77..106
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 117..147
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 245..279
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT ZN_FING 287..315
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 354..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 404..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 660..736
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 404..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 91234 MW; 2D62B24BD7FE7B09 CRC64;
MPSVSKAAAA AVALSGSPPQ TEKPTHYRYL KEFRTEQCPL FLQHKCTQHR PFTCFHWHFL
NQRRRRPIRR RDGTFNYSPD VYCTKYDETT GICPDGDECP YLHRTTGDTE RKYHLRYYKT
GTCIHETDAR GHCVKNGLHC AFAHGPLDLR PPVYDIRELQ AQEALQNGQL GSGDSIPDLQ
PGVLASQAMI EKILGEDPRW QDTNFVLGGY KTEQCPKPPR LCRQGYACPH YHNSRDRRRN
PRKFKYRSTP CPSVKHGDEW GEPSKCESGD NCQYCHSRTE QQFHPEIYKS TKCNDMRQTG
YCPRGPFCAF AHVEKDTMNV VMMQNSNQSK PGAHMFSAES IGITNDWNCH DPNSTNNITN
NNGQSGNISC SNSPTVTSSS GSSSSLSPIG PLCRQRSLAN GGLCSESTTS GVSSPTSSYP
KAPGFEREDQ AKQRNLPAEN NQKISEQDNK QNHLSVFAVV NPLASSITSS ITSSLASSIG
SGSSSPTTLS AINAKALPFY PPSNTVESVI GSALDLHFSD INVASLDKEL EDQETSDLGL
TSQRLLGSSA PVNIPGSLPR SPSLHSSSSL STSPLSSLSQ SLSQPLIPST MTPHQQQPQH
LKSEHNVLGT SASSHNSLGL NGVNGSIWDF VTGSFSPSPS PILSTGTGPS ANSSAHGTEL
ARVRRELDEA KRKIKQWEDS WQQVKQACDA WQREAHEAKE RAKVADTDKQ LALQKKEEVE
NKFKRLQEEF ERLGLSSKFP VLRSYGDIET IPLPKLHSLQ SQLRLDLETV DGVIFQLHSK
KCVVCHEHDR SIVLQPCQHY VLCEHCVSNQ LECPYCKAQP IKW
//
