ID G3W337_SARHA Unreviewed; 1273 AA.
AC G3W337;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Regulatory associated protein of MTOR complex 1 {ECO:0000313|Ensembl:ENSSHAP00000009842.2};
GN Name=RPTOR {ECO:0000313|Ensembl:ENSSHAP00000009842.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000009842.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000009842.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000009842.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat RAPTOR family.
CC {ECO:0000256|ARBA:ARBA00009257}.
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DR AlphaFoldDB; G3W337; -.
DR STRING; 9305.ENSSHAP00000009842; -.
DR Ensembl; ENSSHAT00000009929.2; ENSSHAP00000009842.2; ENSSHAG00000008522.2.
DR eggNOG; KOG1517; Eukaryota.
DR GeneTree; ENSGT00640000091541; -.
DR HOGENOM; CLU_001136_3_0_1; -.
DR TreeFam; TF105729; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0031931; C:TORC1 complex; IEA:InterPro.
DR GO; GO:0031929; P:TOR signaling; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR004083; Raptor.
DR InterPro; IPR029347; Raptor_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR12848; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR PANTHER; PTHR12848:SF16; REGULATORY-ASSOCIATED PROTEIN OF MTOR; 1.
DR Pfam; PF02985; HEAT; 2.
DR Pfam; PF14538; Raptor_N; 1.
DR Pfam; PF00400; WD40; 1.
DR PRINTS; PR01547; YEAST176DUF.
DR SMART; SM01302; Raptor_N; 1.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 18..145
FT /note="Raptor N-terminal CASPase-like"
FT /evidence="ECO:0000259|SMART:SM01302"
FT REGION 687..709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 792..850
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 813..835
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1273 AA; 142837 MW; 046683B3EC86C91C CRC64;
MESEMLQSPL LGLGEEDESD LTDWNLPLTF MKKRHCEKIE GSKSLAQSWR MKDRARYKQS
LDPTVDEVKK LCTSLRRNAK EERVLFHYNG HGVPRPTVNG EIWVFNKNYT QYIPLSIYDL
QTWMGSPSIF VYDCSNAGLI VKSFKQFALQ REQELEVAAI NPSHPLAQMP LPPSMKNCIQ
LAACEANELL PMIPDLPADL FTSCLTTPIK IALRWFCMQK CVSLVPGVTL DLIEKIPGRL
NDRRTPLGEL NWIFTAITDT IAWNVLPRDL FQKLFRQDLL VASLFRNFLL AERIMRSYNC
TPVSSPRLPP TYMHAMWQAW DLAVDICLSQ LPTIIEEGTA FRHSPFFAEQ LTAFQVWLTM
GVENRNPPEQ LPIVLQVLLS QVHRLRALDL LGRFLDLGPW AVSLALSVGI FPYVLKLLQS
SARELRPLLV FIWAKILAVD SSCQADLVKD NGHKYFLSVL ADPYMPAEHR TMTAFILAVI
VNSYNTGQEA CLQGNLIAIC LEQLNDPHPL LRQWVAICLG RIWQNFDSAR WCGVRDSAHE
KLYSLLSDPI PEVRCAAVFA LGTFVGNSTE RTDHSTTIDH NVAMMLAQLI NDGSPMVRKE
LVVALSHLVV QYESNFCTVA LQFIEEEKNY PLPSPAATEG GSLTPVRDGP CTPRLRSVSS
YGNIRAVTTA RSLNKSLQNL SLTEESGSSV AFSPGNLSTS SSASSTLGSP ENEEYILSFE
TIDKMRRVSS YSSLNSLIGV SFNSVYTQIW RVLLHLAADP YPDVSDLAMK VLNSIAYKAT
VNARPQRILD TSSLTQSAPA SPTNKGMHIH QVGGSPPTSS TSSSSLTNDV TKQPGSRDIP
SGRPANVGAM GVQYTPHSHQ FPRTRKMFDK GPDQTTDDAD DTVGHKSFIS ATMQTGFCDW
SAKYFAQPVM KIPEEHDLES QIRKEREWRF LRNTRVRKQA QQIIQKGITR LDDQIFLNRN
PGVPSVVKFH PFTPCIAVAD KDSICFWDWE KGEKLDYFHN GNPRYTRVTA MEYLNGQDCS
LLLTATDDGA IRVWKNFADV EKNPEMVTAW QGLSDMLPTT RGAGMVVDWE QETGLLMTSG
DVRIIRIWDT DREMKVQDIP TGADSCVTSL SCDSHRSLIV AGLGDGSIRV YDRRMALSEC
RVMTYREHTA WVVKAHLQKH PEGHIMSVSV NGDVRFFDPR MPESVNVLQI VKGLTALDIH
PQANLFACGS MNQFTAIYNG NGELINNIKY YDGFMGQRVG AISCLAFHPH WPHLAVGSND
YYISVYSVEK RIR
//
