ID G3W5B7_SARHA Unreviewed; 463 AA.
AC G3W5B7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Riboflavin transporter {ECO:0000256|RuleBase:RU368035};
GN Name=SLC52A3 {ECO:0000313|Ensembl:ENSSHAP00000010622.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000010622.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000010622.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000010622.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plasma membrane transporter mediating the uptake by cells of
CC the water soluble vitamin B2/riboflavin that plays a key role in
CC biochemical oxidation-reduction reactions of the carbohydrate, lipid,
CC and amino acid metabolism. {ECO:0000256|RuleBase:RU368035}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=riboflavin(in) = riboflavin(out); Xref=Rhea:RHEA:35015,
CC ChEBI:CHEBI:57986; Evidence={ECO:0000256|ARBA:ARBA00000215,
CC ECO:0000256|RuleBase:RU368035};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU368035}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU368035}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the riboflavin transporter family.
CC {ECO:0000256|ARBA:ARBA00006366, ECO:0000256|RuleBase:RU368035}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_012409086.1; XM_012553632.1.
DR AlphaFoldDB; G3W5B7; -.
DR STRING; 9305.ENSSHAP00000010622; -.
DR Ensembl; ENSSHAT00000010715.2; ENSSHAP00000010622.1; ENSSHAG00000009166.2.
DR GeneID; 100920084; -.
DR KEGG; shr:100920084; -.
DR CTD; 113278; -.
DR eggNOG; KOG4255; Eukaryota.
DR GeneTree; ENSGT00390000003774; -.
DR HOGENOM; CLU_034789_1_0_1; -.
DR InParanoid; G3W5B7; -.
DR OMA; CGAAAQM; -.
DR OrthoDB; 5477759at2759; -.
DR TreeFam; TF314820; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032217; F:riboflavin transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR009357; Riboflavin_transptr.
DR PANTHER; PTHR12929; SOLUTE CARRIER FAMILY 52; 1.
DR PANTHER; PTHR12929:SF4; SOLUTE CARRIER FAMILY 52, RIBOFLAVIN TRANSPORTER, MEMBER 3; 1.
DR Pfam; PF06237; SLC52_ribofla_tr; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU368035};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368035};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368035}; Transport {ECO:0000256|RuleBase:RU368035}.
FT TRANSMEM 42..61
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 73..93
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 105..129
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 141..158
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 218..238
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 294..315
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 327..349
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 356..379
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 391..415
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
FT TRANSMEM 422..445
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368035"
SQ SEQUENCE 463 AA; 49912 MW; B450A7D8D8226DBA CRC64;
MALLIHLLVC IFGSGSWVAI NGLWVELPLL VEKLPEGWYL PSYLTIIIQL ANVGPLLITL
LHRFRPGCLP EIPIIYVVLA VGTTACLLFA FLWEKTSVVA GAPHSTAFLV LTFFLALVDC
TSSVTFLPFM ARLPARYLTS YFVGEGLSGL LPALVALAQG SGLNTCAQVT NSSITTEPPN
STKASFILES LNITVKPDLT TSTPQPETCY LQANFSPFVF FLLLTVMMAS CLAAFFGLTR
LPKQWELSTE DLLVSQVTLR SFQLQETGSS NRDSCPSVVL PEEKQVTIRP QAQLAFIYFL
VVFVNALTNG ILPSVQTYSC MPYSSMAYHL SAALSAMANP LSCLLAMCLS SRSLSWLGMI
TVVGTGFGAF NMATAVLSPC PPLKGSPWGE ALIVISWVLF TGTLSYVKVM TGVLLRDLSH
SALVWCGAAE QLGSAFGAIL MFPLVNVLHF FKSADGSGLQ CPS
//
