GenomeNet

Database: UniProt
Entry: G3W717_SARHA
LinkDB: G3W717_SARHA
Original site: G3W717_SARHA 
ID   G3W717_SARHA            Unreviewed;      3999 AA.
AC   G3W717;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   22-NOV-2017, entry version 42.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSSHAP00000011222};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011222, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000011222}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000011222}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000011222}.
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DR   EMBL; AEFK01159958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159965; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159966; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01159967; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000011222; -.
DR   Ensembl; ENSSHAT00000011316; ENSSHAP00000011222; ENSSHAG00000009656.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3W717; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 3.
DR   Pfam; PF00622; SPRY; 2.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3311   3330       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3532   3552       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3606   3625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3742   3763       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3800   3821       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3876   3899       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       57    254       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      389    594       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3055   3090       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   3999 AA;  456651 MW;  7D91A7FAAC37FD55 CRC64;
     SYQLTSGYKP APMDLSFIKL TPSQEAMVDK LAENAHNVWA RDRIRQGWTY GIQQDVKNRR
     NPRLVPYALL DDRTKKSNKD SLREAVRTLL GYGYNLEAPD QDHATRSEVC SGTGEKFRIF
     RAEKTYAVKA GRWYFEFEAV TAGDMRVGWS RPGCQPDQEL GSDERAFAFD GFKAQRWHQG
     SEHYGRSWQA GDVVGCMVDM NEHTMMFTLN GEILLDDSGS ELAFKDFEVI DGFIPVCSLG
     VAQVGRMNFG KDVSTLKFFT ICGLQEGYEP FAVNTNRDIT MWLSKRLPQF LQVPSNHEHI
     EVTRIDGTID SSPCLKVTQK SFSSQNSGTD IMFYRLSMPI ECAEVFSKTA AGGLPGNSLF
     GPKNDLEDYD ADSDFEVLMK TAHGHLVPDR VEKEKEATKP EFNNHKDYAQ EKPSRLKQRF
     MLRRTKPDYS TSHSARLTED VLADDRDDYD YLMQTSTYYY SVRIFPGQEP ANVWVGWITS
     DFHQYDTVFD LDRVRTVTVT LGDEKGKVHE SIKRSNCYMV CAGESMSPGQ GRNNNGLEIG
     CVVDAASGLL TFTANGKELS TYYQVEPSTK LFPAVFAQAT SPNVFQFELG RIKNVMPLSA
     GLFKSEHKNP IPQCPPRLHV QFLTHVLWSR MPNQFLKVDV SRISERQGWL VQCVDPLQFM
     SLHIPEENRS VDILELTEQE ELLKFHYHTL RLYSAVCALG NNRVAHALCS HVDEPQLLYA
     IENKYMPGLL RTGYYDLLID IHLSSYATAR LMMNNEFIVP MTDETKSITL FPDENKKHGL
     PGIGLSTSLR PRMQFSSPSF VSISSEYYQY SPEFPLDILK SKTIQMLTEA VKEGSLHARD
     PVGGTTEFLF VPLIKLFYTL LIMGIFNNED LKHILQLIEP SVFKEAASQE EENEVLEKEH
     NIEEPVLEGG SEEETKGRKM PKEGLLQMKL PEPVKLQMCL LLQYLCDCQV RHRIEAIVAF
     SDDFVAKLQD NQRFRYNEVG NGLAFWALLV MGVSNYFKNP YLFKLINMLL NFKDEKNECP
     CPEDIRDQLL DFHEDLMTHC GIELDEDGGL DGNSDLTIRG RLLYLVEKVT YLKKKQTEKP
     VENDSRKPST LQQLISETMV RWAQESVIED PELVRAMFVL LHRQYDGIGG LVRALPKTYT
     INGVSVEDTI NLLASLGQIR SLLSVRMGKE EEKLMIRGLG DIMNNKVFYQ HPNLMRALGM
     HETVMEVMVN VLGGGESKEI TFPKMVANCC RFLCYFCRIS RQNQKAMFDH LSYLLENSSV
     GLASPAMRGS TPLDVAAASV MDNNELALAL REPDLEKVVR YLAGCGLQSC QMLVTKGYPD
     IGWNPVEGER YLDFLRFAVF CNGESVEENA NVVVRLLIRR PECFGPALRG EGGNGLLSAM
     EEAIKIAEDP SRDGPSPTNG SSKTLDLTTE EDDTIHMGNA IMTFYAALID LLGRCAPEMH
     LIHAGKGEAI RIRSILRSLI PLGDLVGVIS IAFQMPTIAK DGNVVEPDMS AGFCPDHKAA
     MVLFLDRVYG IEVQDFLLHL LEVGFLPDLR AAASLDTAAL SATDMALALN RYLCTAVLPL
     LTRCAPLFAG TEHHASLIDS LLHTVYRLSK GCSLTKAQRD SIEVCLLSIC GQLRPSMMQH
     LLRRLVFDVP LLNEHAKMPL KLLTNHYERC WKYYCLPGGW GNFGAASEEE LHLSRKLFWG
     IFDALSQKKY DFYLVEMAKK ILSWIGGKKC PSMYLNANVS SYSSKILIID EIAVLIPVPI
     PTRPSMLIFA LFSVKYNIKT NCYWHLFQLA NGWIYGEIYS DSSKVQPLMK PYKLLSEKEK
     EIYRWPIKES LKTMLAWGWR IERTREGDSM ALYTRTRRIS QTSQVSIDTA HGYSPRAIDM
     SNVTLSRDLH AMAEMMAENY HNIWAKKKKL ELEAKGGGNH PLLVPYDTLT AKEKAKDREK
     AQDILKFLQI NGYAVSRGFK DLELDTPSIE KRFAYSFLQQ LIRYVDEAHQ YILEFDGGSR
     SKGEHFPYEQ EIKFFAKVVL PLIDQYFKNH RLYFLSAASR PLSTGGHASN KEKEMVTSLF
     CKLGVLVRHR ISLFGNDASS IVNCLHILGQ TLDARTVMKT GMDSVKTALR AFLDNAAEDL
     EKTMENLKQG QFTHTRNQPK GVTQIINYTT VALLPMLSSL FEHIGQHQFG EDLILEDVQV
     SCYRILTSLY ALGTSKSIYV ERQRSALGEC LAAFAGAFPV AFLETHLNKH NTYSIYNTKS
     TRERTALNLP ASVEEVCPNI PSLEKLMDEI VELAESGIRY TQMPHVMEVI LPMLCSYMSR
     WWEHGPENNP DRVDTCCTAL NSEHMNTLLG NILKIIYNNL GIDEGAWMKR LAVFSQPIIN
     KVKSQLLKSH FLPLMEKLKN KAAIVVSDED HLKAEARGDM SEAELLILDE FTTLARDLYA
     FYPLLIRFVD FNRAKWLKEP NSEAEELFRM VAEVFIYWSK SHNFKREEQN FVVQNEINNM
     SFLITDTKSK MSKAAVTDQE RKKMKRKGDR YSMQTSLIVA ALKRLLPIGL NICAPGDQEL
     IALAKNRFSM KDTEDEVRDI IRSNLHLQGK LEDPAIRWQM ALYKDLPNRT EETSDPEKTV
     ERVLDIANVL FHLEQRPTNM GRRYYSVVEH PQRSKKAVWH KLLSKQRKRA VVACFRMAPL
     YNLPRHRAVN LFLQGYEKSW IETEEHYFED KLIEDLAKPG IEPPEEDEDI KKVDPLHQLI
     LLFSRTALTE KCKLEEDFLY MAYADIMAKS CHDEEDDDGE EEVKSFEEKE MEKQKLLYQQ
     ARLHDRGAAE MVLQTISASK GETGPMVAAT LKLGIAILNG GNSTVQQKML DYLKEKKDVG
     FFQSLAGLMQ SCSVLDLNAF ERQNKAEGLG MVTEEGSGEK VLQDDEFTCD LFRFLQLLCE
     GHNSDFQNYL RTQTGNNTTV NIIISTVDYL LRVQESISDF YWYYSGKDVI DEQGQRNFSK
     AIQVAKQVFN TLTEYIQGPC TGNQQSLAHS RLWDAVVGFL HVFAHMQMKL SQDSSQIELL
     KELMDLQKDM VVMLLSMLEG NVVNGTIGKQ MVDMLVESSN NVEMILKFFD MFLKLKDLTS
     SDTFKEYDPD GKGIISKRDF HKAMESHKHY TQSETEFLLS CAETDENETL DYEEFVKRFH
     EPAKDIGFNV AVLLTNLSEH MPNDTRLQTF LELAESVLNY FQPFLGRIEI MGSAKRIERV
     YFEISESSRT QWEKPQVKES KRQFIFDVVN EGGEKEKMEL FVNFCEDTIF EMQLAAQISE
     SDLNERSVNK EETEKENPEE QEPRMGFFSI TTVKSALIAL RYNILTLMKM LTLKSLKKQM
     KKVKKMTMKD LVMALFSSYW SILVGLLHFI SSVFRGFFRI MCSLLLGGSL VEGAKKIKVA
     ELLANMPDPT QDEVRGEGEE GERKAIEMAL PTEDLTDLKE LTEESDLLSD IFGLDLKREG
     GQYKLIPHNP NAGLSDLMSN PIPVPEVQEK CQEQKVKEDE KEEKEEMKSE PEKAEGEDGE
     KEEKSKEDKG KQKLRQLHTH RYGEPEVPES AFWKKIIAYQ QKLLNYFARN FYNMRMLALF
     VAFAINFILL FYKVSTSSVV EGKEIPSPSA SENSRISSLD STSHRLITVH YVLEESSGYM
     EPTLRILAIL HTVISFFCII GYYCLKVPLV IFKREKEVAR KLEFDGLYIT EQPSEDDIKG
     QWDRLVINTQ SFPNNYWDKF VKRKVMDKYG EFYGRDRISE LLGMDKAALD FSDAREKKKP
     KKDSSLSAVL NSIDVKYQMW KLGVVFTDNS FLYLAWYMTM SVLGHYNNFF FAAHLLDIAM
     GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED GDTPDMKCDD
     MLTCYMFHMY VGVRAGGGIG DEIEDPAGDE YEIYRIIFDI TFFFFVIVIL LAIIQGLIID
     AFGELRDQQE QVKEDMETKC FICGIGNDYF DTVPHGFETH TLQEHNLANY LFFLMYLINK
     DETEHTGQES YVWKMYQERC WEFFPAGDCF RKQYEDQLN
//
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