ID G3W7I7_SARHA Unreviewed; 1894 AA.
AC G3W7I7;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Plexin B3 {ECO:0000313|Ensembl:ENSSHAP00000011392.2};
GN Name=PLXNB3 {ECO:0000313|Ensembl:ENSSHAP00000011392.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011392.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011392.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011392.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR STRING; 9305.ENSSHAP00000011392; -.
DR Ensembl; ENSSHAT00000011488.2; ENSSHAP00000011392.2; ENSSHAG00000009796.2.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01020000230394; -.
DR HOGENOM; CLU_001436_1_1_1; -.
DR InParanoid; G3W7I7; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IEA:Ensembl.
DR GO; GO:0019904; F:protein domain specific binding; IEA:Ensembl.
DR GO; GO:0051022; F:Rho GDP-dissociation inhibitor binding; IEA:Ensembl.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:Ensembl.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:Ensembl.
DR GO; GO:0007162; P:negative regulation of cell adhesion; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IEA:Ensembl.
DR GO; GO:0050918; P:positive chemotaxis; IEA:Ensembl.
DR GO; GO:0001938; P:positive regulation of endothelial cell proliferation; IEA:Ensembl.
DR GO; GO:0010976; P:positive regulation of neuron projection development; IEA:Ensembl.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd12791; RasGAP_plexin_B3; 1.
DR CDD; cd11277; Sema_plexin_B3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF33; PLEXIN-B3; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 3.
DR SMART; SM00630; Sema; 1.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..1894
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5029873227"
FT TRANSMEM 1249..1269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 10..455
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
SQ SEQUENCE 1894 AA; 208968 MW; 9240BCB8F0EF69DA CRC64;
MARLLPSPFL LLLSLSSWKS WHFVLAHHFF APNTTFNHLA MDADTGMLYV GAVNHLYQLT
PDLEQVGEAV TGPIWDSPDC LPFRDPAECP QARPTDNANQ LLLVSGRARE LVACGQVRQG
VCEKRSLRNV AQLLFRAEDP GDGQFVAANA PGVATVGLVV STPGRDLLYV ARGLAGKLSA
GVPPLTVRQL AGPQAFSSEG LGRLVVGDFS DYNNSYVGAF AGTQFAYFVF RRRGSRTQAD
YRSYVARVCL NDANLYSYVE MPLICRGHSL VQAAYLAPGQ GGGTLLVVAS PGPTGGSALC
AFPLQEVDRQ MERARRLCYT VGGQGPAGEE VTIEYGVTSR CVFLPSDSPD SYPCGDEHTP
SPIASHQPLE AEPLLTSVPH LSAVAALEEV GHTIVFLGDT QGQLHKVFLN GSTGQLYSSL
PVGPPDTAVS PDLLLNRNGS HLYVMTTSQV TKLPISSCQN FTDCPSCLQA QDPFCGWCVL
QGRCVRKEEC VGFEQSHQWL WSYGPPEGRR CLAIESLVPS QQPRQEQGQV TMVVPQLPSL
APDKYFHCAF HNYETLAHVE GTQVVCESPP QDQLPPNAEG TDHVTVPLAL MFEDVSVAVT
NFSFYDCKAT GALDIAAPCS ACVRSPWRCH WCPQSAFCVY GDGCPDGEKT VYHAQEVDVL
MKGPDFCPHV EGLGTSHLVP VGWETRLALR VRNLHYYQNK AASYHCWLEL PGALLGLQAS
LEEGDRGSQL IRCQAQQFRP SPPRKELRVP IYVTRGNTQR VDNAADIYVT LYDCTVGHED
CSHCQAADRN LNCVWCGQGR PVCNYRPLCP PEAVESLCPL PSIHSIKPLT GPPEGGVVLT
ILGSNLGSRL EDVTNAVSVA GQPCRLDPTL YRISTQIVCV TSPAPKDTTG PIKVTIKNRP
PSKSAQLFSY RDPVLSALSP WQGPKAGGTL LTIFGQHLLT ENNVRAFLGD EPCLIQGPVC
PETIVCLTGP RATPGEADLL VVFGLAQRTL AKGHFSYRPD PQLLSAEPSV SFRGGGRVIR
VTGSNLDVVQ RPLLSVWLAE APAGPQQLEP KQAAEHQCED GGRPQAARRR AASQTCTWLE
AGLLECSTVC WANSSGLLLC PSPAIPGVAR LRRMFFTLDN VLVDFANVSG GKDFLYQPNP
RLHPLSRDRP AHPYRLKPGN VLDVEGEGLN LGISKEEVQV QIGKGECVVK TLTLTHLYCE
PPMWAPQPLN SSSALPEFIV QMGNLQLNLG PVKYEVETTL PSFPTEAQIG LGVGVAVLIS
MVLLLILMYR RKSKQAMRDY KKVLVQLENL EISVGDQCRK EFTDLMTEMT DLSSDLEGSG
IPFLDYKTFT ERVFFPGHHG SPLRSEIDVP DARQATVKQG LNQLANLLNS KLFLIKFIHT
LEEQPTFSQR DRCYVASLLS LALHGKLEYL TDIMKTLLSD LTAQYVHKNP KLMLRRTETM
VEKLLTNWMS ICLYSFLKEV AGEPLYMLFR AIKYQVDKGP VDAVTGKAKR TLNDSRLLRE
DVEFWPLTLT VLVGPATGTG EPQRVPARVL NTDTITQVKE KVLDQIYKGT PFSQRPSVHA
LDLEWRSGVA GHLTLSDEDL TSVTQNQWKR LNTLQHYKVP DGATVGLIPR MHNGSSISKS
PNQSFLSGES LPMLEDGDES GIRLWHLVKS TEEPEVAKQR RSSLRDRERA KAIPEIYLTR
LLSMKGTLQK FVDDTFQAIL SVDRPVPIAV KYLFDFLDEL ADKHGIEDQE TLHIWKTNSL
LLRFWVNTLK NPQFIFDVRV SDNVDAILTV IAQTFIDSCT ISEHKVGRDS PVNKLLYARE
IPRYKQMVEK YYSDIRQNTT ASYQEMNSAL TELSGNYASD ITCLVALHEL YNYINKYYDQ
IISALEEDPV GQKMQLAYRL QQIAALVENK VTDL
//
