ID G3W837_SARHA Unreviewed; 871 AA.
AC G3W837;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Protein phosphatase 4 regulatory subunit 4 {ECO:0000313|Ensembl:ENSSHAP00000011592.2};
GN Name=PPP4R4 {ECO:0000313|Ensembl:ENSSHAP00000011592.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011592.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011592.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011592.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3W837; -.
DR STRING; 9305.ENSSHAP00000011592; -.
DR Ensembl; ENSSHAT00000011688.2; ENSSHAP00000011592.2; ENSSHAG00000009960.2.
DR eggNOG; KOG0211; Eukaryota.
DR GeneTree; ENSGT00510000047895; -.
DR HOGENOM; CLU_010601_0_0_1; -.
DR InParanoid; G3W837; -.
DR TreeFam; TF313717; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0008287; C:protein serine/threonine phosphatase complex; IEA:Ensembl.
DR GO; GO:0019888; F:protein phosphatase regulator activity; IEA:Ensembl.
DR GO; GO:0001835; P:blastocyst hatching; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR039918; PPP4R4.
DR PANTHER; PTHR21467; PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4 PPP4R4; 1.
DR PANTHER; PTHR21467:SF0; SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02985; HEAT; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 213..250
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 252..290
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REGION 714..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 811..871
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..739
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..763
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..859
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 871 AA; 99486 MW; ED0EE972B0F0136C CRC64;
MHPLPLFAEM DFSQNSLFGY IEDLQELTII ERPVRRSLKT PEEIERLTVD EELNDIERAV
YLLSSGQDVQ GTSVVANLPF LMRQNPAETL RRVLPKVREV LHVAGVEMQL TAAASFLTIL
QEESVSIQNY SHSFLHIILQ HVEHRDAGVS NAWLETLLSV IESLPKETLR HEILNPLVSK
AQLSQTLQSR LVSCKLLGKL ANKFEAHIIK REILPLVKSL CQDVEYEVRS CMCRQLDIIA
HGIGTELTKS VVLPELIELA RDESSSVRLA AFETLVNLLE MFDADDRSQT ILPLVKSFCE
KSFKTDETIL LSLSLHLGKL CHGLYGILTP DQHLRFLEFY KKLCTLGLQQ ENGHNDNQIP
PPNQEQEKRY ASVRKNCAYN FPAMIIFVDP KNFHMELYST FFCLCHDPEV PVRHTIAICF
YEVSKLLSTG VYLIYKELIA LLQDESLEVL DALVDHLPET LELLTTGGES SVQENKLLAV
PDLIPALTAA EQRAAGSLKW RTHEKILQKY ACLPHIISSD QIYYRFLHRM FTIMMTNNVL
PVQKAASRTL CIFLRYNRKQ EQRHEIIQKL IEQLGQGKSY WYRLRFLDTC EFIIELFSKS
FFCKYFFLPA LELTHDPVAN VRMKLCYLLP KVKSTLKIPA DKHLLQQLEL CVRKLLCQEK
DKDVLAIVKR TVLELDRMEM SMDAFQKRFY EKDLLDQEKE REELLLLEME QLEKEKQQNE
GRPSSDKIFE KKRRDNKTTA VLPKTIPMSV AGSSSCTPST SKEIKKSKLV RSQSFSSQAL
HPKYGNLEKC TGKNSTTGYA SVSGIGKPSV LSYTDDSFRT RNSSGNISPY SSNTSLPSTS
RNMSNSVDQK NNGSKDTQPR KATLKSRKSN P
//
