ID G3W845_SARHA Unreviewed; 842 AA.
AC G3W845;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=FYN binding protein 1 {ECO:0000313|Ensembl:ENSSHAP00000011600.1};
GN Name=FYB1 {ECO:0000313|Ensembl:ENSSHAP00000011600.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011600.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011600.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011600.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_012396889.1; XM_012541435.1.
DR RefSeq; XP_012396890.1; XM_012541436.1.
DR RefSeq; XP_012396891.1; XM_012541437.1.
DR RefSeq; XP_012396892.1; XM_012541438.1.
DR AlphaFoldDB; G3W845; -.
DR STRING; 9305.ENSSHAP00000011600; -.
DR Ensembl; ENSSHAT00000011696.2; ENSSHAP00000011600.1; ENSSHAG00000009968.2.
DR GeneID; 100933793; -.
DR KEGG; shr:100933793; -.
DR CTD; 2533; -.
DR eggNOG; ENOG502QTTQ; Eukaryota.
DR GeneTree; ENSGT00530000063460; -.
DR HOGENOM; CLU_339375_0_0_1; -.
DR InParanoid; G3W845; -.
DR OMA; KSSTWSW; -.
DR OrthoDB; 5403214at2759; -.
DR TreeFam; TF337003; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032991; C:protein-containing complex; IEA:Ensembl.
DR GO; GO:0008289; F:lipid binding; IEA:InterPro.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:Ensembl.
DR CDD; cd11867; hSH3_ADAP; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR043443; FYB1/2-like.
DR InterPro; IPR035540; FYB_hSH3.
DR InterPro; IPR029294; hSH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR16830:SF13; FYN-BINDING PROTEIN 1; 1.
DR PANTHER; PTHR16830; SH2 CONTAINING ADAPTOR PRAM-1 RELATED; 1.
DR Pfam; PF14603; hSH3; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 523..584
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 759..827
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 27..513
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..655
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..702
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 58..72
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 287..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..473
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..513
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..689
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 842 AA; 92850 MW; E15982D2E658AB02 CRC64;
MDGKADVKSL MAKFNTGGNL TEEISIGSRP FKAGGHPAPS GIQAKKNIFT NQENASPPPG
PNNLPKFGTP RPPLGVKPSF EEKNDKDPKP PYLKPTGVGQ RFGTPASSAN RDSEVKPGFL
KPVGPRAFDQ PKEESKPVFP RPSGNKALLH AVNQENDLKA PGQKPVFNAS AQENESKPVF
AKLAGPKGKF LTSSQDHDHK PPFTKPPIGQ KPFLNADISP DDQSPNKGTF PQKGPPSKPK
VNPLKPTKED TENKDQSIDP STMPFPGVTL KPVASRGTPG LAPSLPKNSE EKKEERKIDA
AKNVFMSKMS QDDSSSGATP PKLPKPPSKL TVVGPWDRSQ EKEKGDKHSA VPKQKPLPAL
FTLGPAPQKP SRPPTVDLAR FRKASAANIS NKGTVPYSVT TSPPPPPPAH PSAQPALPTS
YPTQPPVPSL PPRNIKISPE PRSSINEENY DDVDMQSNDP GNPDEDQDSN EETYEDIEAT
KEREKKRDKE EKKRLEQEKK EQREKEKKEQ EIKKKFKLTG PVQVLHQAKA CCDVKGGKNE
LSVKQGEEIE IIRITDNPEG KWLGRTSRGT YGYIKTTAVE IDYDSLKRKK NSMNTLPSRP
TEDDQELYDD VAEHSSISSH SQSGSGGMFP IKDDEIYDGV EEDDDNGSTL QGEEKSNSWT
WGILKMLKGK DEKKKSIRKK SKDTESDSNE DMVFPSPPKN LGLDVGDEVY DDVDSSDFPA
PPIEVSLGAN FGKSKSEEKD LKKLKKQEKE EKEFKKKFKF DGEIRVLYTT QVVPTLPSKK
WGTRDLQLKP GESLEVIQST DDTKVLCRNE EGKYGYVLRS CLVDNEGEIY DDIADGCIYD
ND
//
