ID G3W8U6_SARHA Unreviewed; 885 AA.
AC G3W8U6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Epithelial cell transforming 2 {ECO:0000313|Ensembl:ENSSHAP00000011851.2};
GN Name=ECT2 {ECO:0000313|Ensembl:ENSSHAP00000011851.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000011851.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000011851.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000011851.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3W8U6; -.
DR Ensembl; ENSSHAT00000011948.2; ENSSHAP00000011851.2; ENSSHAG00000010171.2.
DR GeneTree; ENSGT00940000156299; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:2000431; P:regulation of cytokinesis, actomyosin contractile ring assembly; IEA:InterPro.
DR CDD; cd17733; BRCT_Ect2_rpt1; 1.
DR CDD; cd17732; BRCT_Ect2_rpt2; 1.
DR CDD; cd01229; PH_Ect2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 3.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR026817; Ect2.
DR InterPro; IPR049396; ECT2_BRCT0.
DR InterPro; IPR049395; ECT2_PH.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR PANTHER; PTHR16777; PROTEIN ECT2; 1.
DR PANTHER; PTHR16777:SF2; PROTEIN ECT2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF21243; ECT2_BRCT0; 1.
DR Pfam; PF21242; ECT2_PH; 1.
DR Pfam; PF12738; PTCB-BRCT; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00292; BRCT; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 147..220
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 235..324
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 422..611
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 361..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 383..421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 885 AA; 99987 MW; 80A7D3DA795BBCFB CRC64;
MADNSLLVST AVKSLLADTS IFDSKVPEIS KENELTGSTS DAEEEMPQIE TRVILVQEAE
RQEQLIRALE EIKVPYLKME SVKDFEASDS PEFENIFVVM DFEDAVFSDL YKADYRIVGP
PVVLNCAKKG EPLPYSCRPL YCASMLNLVL CFTGFRKKEE LVKLVTLAHY MGGTIRKDFN
SKVTHLVANC TQGEKFRVAV SLGTPIVKPE WIFKAWERRN EQDFCAAADE FINEFKVPPF
QDCMLSFLGF SDEEKANMEE MTEMQGGGHY LPVGDERCTH LIVEENAIKE LPFEPSKKLY
VVKQEWFWGS IQMDARAGES MYLYEKANTP ELKKSVSLLS LSTPNSNRKR RRLKETLAQL
ARETDISPFP PRKRPSAEHS LSIGSLLDIS NTPESSTSYG ETPKSCTKPS KNSTPVPPKQ
SARWQVAKEL YQTESNYVNI LATIIQLFQV PLEEEGQRGG PILAPEEIKA IFGSIPDIFD
VHTKIKEDLE DLIINWNESK SIGDIFLKYS KDLVKIYPPF VNFFEMSKET IVKCEKLKPR
FHAFLKINQA KPECGRQSLA ELLIRPVQRL PSVALLLNDL KKHTAEDNPD KNTLERAIGS
LKEVMTHINE DKRKTEAQKQ IFDVVYEVDG CPANLLSSHR SLVQRVETIS LGEHPCDRGE
QVTLFLFNDC LEIARKRHKV IGTFKSPHGH TRPPAALKHI HLMPLSQIKK VLDIKETEDC
HNAFGLLVRP PTEQANVLLS FQMTSEDLPK DTWLKMLCRH VANTICKADA ENLIYSADPE
SFEVNTKDMD STLSRASRAI KKTSKRVTRA FSFTKTPKRA FRRTLITAQS SVEGRSPCSS
SDTYIGSRLT STTSLAGIPS PSLVSLPSFF EKRSHTLSRS TTHLI
//
