ID G3WDH1_SARHA Unreviewed; 1036 AA.
AC G3WDH1;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Myosin IH {ECO:0000313|Ensembl:ENSSHAP00000013476.2};
GN Name=MYO1H {ECO:0000313|Ensembl:ENSSHAP00000013476.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013476.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000013476.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000013476.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR AlphaFoldDB; G3WDH1; -.
DR STRING; 9305.ENSSHAP00000013476; -.
DR Ensembl; ENSSHAT00000013587.2; ENSSHAP00000013476.2; ENSSHAG00000011518.2.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000156430; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; G3WDH1; -.
DR TreeFam; TF312960; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 1.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF353; UNCONVENTIONAL MYOSIN-IH; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Membrane {ECO:0000256|SAM:Phobius};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 55..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..707
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 859..1033
FT /note="TH1"
FT /evidence="ECO:0000259|PROSITE:PS51757"
FT REGION 584..606
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT BINDING 121..128
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1036 AA; 119984 MW; DA8A8DAC1EB9E640 CRC64;
MDSKKEEMRR KHIKLHMEGA LTARDKVGVQ DFVLLDSYTS ESAFMDNLRK RYRENLIYTY
IGTLLVSVNP YQELGIYTMK QMELYQGVNF FELPPHVYAI ADNAYRMMCS ELNNHFILIS
GESGAGKTEA SKKILQYLAV TCPMTESLQI ARDRLLLSNP VLEAFGNAKT LRNDNSSRFG
KYMDIQFDFK GIPVGGHIIS YLIEKSRVVF QNHGERNFHI FYQLLEGGED DLLSYLGLVR
STQAYFYLNQ GRCAKVTSID DKNDWETVVK AFSIIDFNET DLENLFGIVA SVLHLGNVHF
VEDGDGCVTI PDNSQIRWIA KLLGIHLSAL QEALTYRKIE AKSEEVLCPL NIDLSVYSRD
AMAKAIYGRT FTWLVNKING SLANKDFTRK TVIGLLDIYG FEVFDKNGFE QFCINYCNEK
LQQLLIEMTL KAEQIEYELE GIEWEPIQYF NNKIICDLVE EKHKGIISIL DEECLRPGTP
TDLSFLEKLE EKVGKHAHFQ TRKLAGPKAK KRISWLEFRL LHYAGEVTYC ARGFLEKNND
LLFRHLKKVL CGSKNGIIKE CFHVEELENR KRPTTVGTQF KNSVANLINI LMSKEPSYIR
CIKPNEGKEP SKFDDFLIRH QIKYLGLMEH LRVRRAGFAY RRKYEHFLQR YKSLCPDTWP
HWHGSPLEGV EKLIKYIGYK PEEYKLGRTM IFIRFPKTLF ATEDAFEFSK HQLVAKIQST
YKGCLERRNY LKKKQAAITL EAYWRGALAR KEIKRRKWAV QIIRKFIRGF ISRNKTVCSE
NEDYIIFVRK NYILNLRKHV PQNVLDKRWL KPPAMLENTS EMLKKLCTRN LVRRYCRGVT
ARRKMQQKVV ASDLFQGKKA GYPESLDQPF ADSRIDEADI NPKVLQLLGS EKIQYGTPVV
KYDRNGFKAR QRQLILTEKA LYVVELAKIK QRIDYESLKG ISTSNLNDGL FVIHVFPEDN
KQKGDIILLC ERIFETVTKL SMVAKKEGLV RIVQGSLQFY ISLGKEGTII FNTGQEEQIY
KDKDGQLIVV SVPMKS
//
