ID   G3WEL1_SARHA            Unreviewed;       630 AA.
AC   G3WEL1;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   27-MAR-2024, entry version 55.
DE   RecName: Full=Galactose-3-O-sulfotransferase 2 {ECO:0008006|Google:ProtNLM};
GN   Name=LOC111719705 {ECO:0000313|Ensembl:ENSSHAP00000013866.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000013866.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000013866.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000013866.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the galactose-3-O-sulfotransferase family.
CC       {ECO:0000256|ARBA:ARBA00008124}.
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DR   AlphaFoldDB; G3WEL1; -.
DR   Ensembl; ENSSHAT00000013983.2; ENSSHAP00000013866.2; ENSSHAG00000011858.2.
DR   eggNOG; ENOG502QTXT; Eukaryota.
DR   GeneTree; ENSGT00950000182923; -.
DR   HOGENOM; CLU_040616_1_1_1; -.
DR   TreeFam; TF314802; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0001733; F:galactosylceramide sulfotransferase activity; IEA:InterPro.
DR   GO; GO:0009247; P:glycolipid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR009729; Gal-3-0_sulfotransfrase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR14647; GALACTOSE-3-O-SULFOTRANSFERASE; 1.
DR   PANTHER; PTHR14647:SF62; GALACTOSE-3-O-SULFOTRANSFERASE 2-LIKE ISOFORM X1; 1.
DR   Pfam; PF06990; Gal-3-0_sulfotr; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        18..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   REGION          152..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          607..630
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        186..207
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   630 AA;  72903 MW;  A0CC2BE46955C9CC CRC64;
     MYVLKKAQLV PKTQLGRFWI LITFISILCI SLQMLGNLQQ SCKQEIKHLI LQQNINLPQT
     SQVQKNCNST LSPHSLNRVP IGHTEAIPTQ VSLQRMKQNK ALNPTLQMQN DLNYSEENAL
     VDLWWLSYSS KHPKPSLWGS KKVAKDKDWT LPQIKSSKPP PKAAQMNKKR DLGKKMEMVV
     SSASRSFDSV GGSQQNHPQS TIPKYGRAQS QGKIMKDSLF RQKISLKDPI TRSRTPLSPS
     LTPRLRDGLF SSHEAACTSK THIFFLKVHK SASSTIMNIL FRFGEQRNLT FALPINQNSQ
     LFYPSYFVAE VVEGFTGETS PSFDIMCHHL RFLQTEVQRV MPNDTFYFSI MRNPIHLMES
     SFSYYKGSSS FFNAKSLDDF LNNTSKFYDP LKTDSQYSRN LMAFDFGFNH NGKASAQHTR
     LLARVIESQF DLVLIAEYFD ESMVLLKDAL CWSLDDVMSF PINQQDASYR SSLSPSTIQK
     IKSWNKLDWE LYLHFNRTFW ERINQSMSRE YLQQEVAALR KRRKQLAKIC LQKEQSVHSW
     NIEDKLLKPF QYGRAKILGY NLRHGLDEAT KQACQSFVMP ELQYSKRLYE RQFPQKALWL
     SQAKKYSKAH SKKKERPPKS YSQTSEASFF
//