ID G3WGG2_SARHA Unreviewed; 586 AA.
AC G3WGG2;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Lamin B1 {ECO:0000313|Ensembl:ENSSHAP00000014517.1};
GN Name=LMNB1 {ECO:0000313|Ensembl:ENSSHAP00000014517.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000014517.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000014517.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000014517.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer
CC on the nucleoplasmic side of the inner nuclear membrane, which is
CC thought to provide a framework for the nuclear envelope and may also
CC interact with chromatin. {ECO:0000256|ARBA:ARBA00037635}.
CC -!- SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000256|ARBA:ARBA00024186}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR RefSeq; XP_003759549.1; XM_003759501.2.
DR AlphaFoldDB; G3WGG2; -.
DR STRING; 9305.ENSSHAP00000014517; -.
DR Ensembl; ENSSHAT00000014639.2; ENSSHAP00000014517.1; ENSSHAG00000012393.2.
DR GeneID; 100929634; -.
DR KEGG; shr:100929634; -.
DR CTD; 4001; -.
DR eggNOG; KOG0977; Eukaryota.
DR GeneTree; ENSGT00940000157199; -.
DR HOGENOM; CLU_012560_9_2_1; -.
DR InParanoid; G3WGG2; -.
DR OMA; IGQWAIK; -.
DR OrthoDB; 72418at2759; -.
DR TreeFam; TF101181; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005638; C:lamin filament; IEA:Ensembl.
DR GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0043274; F:phospholipase binding; IEA:Ensembl.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:Ensembl.
DR GO; GO:0006998; P:nuclear envelope organization; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 2.60.40.1260; Lamin Tail domain; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 2.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR001322; Lamin_tail_dom.
DR InterPro; IPR036415; Lamin_tail_dom_sf.
DR PANTHER; PTHR45721; LAMIN DM0-RELATED; 1.
DR PANTHER; PTHR45721:SF3; LAMIN-B1; 1.
DR Pfam; PF00038; Filament; 1.
DR Pfam; PF00932; LTD; 1.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR SUPFAM; SSF74853; Lamin A/C globular tail domain; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
DR PROSITE; PS51841; LTD; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023289};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT DOMAIN 32..384
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT DOMAIN 426..542
FT /note="LTD"
FT /evidence="ECO:0000259|PROSITE:PS51841"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 387..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 545..586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 29..366
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 388..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 586 AA; 66949 MW; E2C9DBD209864CD5 CRC64;
MATTTPMVQR TGGRASGPST PLSPTRLSRL REKEELRELN DRLAVYIDKV RSLELEKSVL
QLQVTEHDRE LTGLKTLYET ELADARRALD DTACERAKLQ IELGKFKAEH DQLLLNYTKK
ESDLNGAQIK LREYEASLNA KEAALATALG DKKSLENDLK ELRDQIVQLE ASLAATKNQL
ADETLLKVDL ENHCQSLTED LEFRKNMYEE EINETRRKHE TRLVEVDSGR QIEYEYKLAQ
AVHEMREQHN EQVKLYKEEL EQSYHAKLEN ARLSSEMTAF TVNSAREELM ESQMRIESLS
SQLSNLQKEY RACLDRMQEL EDLLVKERDN SRRLLSDKER EMAEVRNQMQ QQLNEYEQLL
DVKLALDVEI RAYRKLLEVE EERLKLSPTP SSRVTVSRAS SSQSVRTTKG KRKRVDVEES
EASSSISISH SASATGNVCI EKIDVDGKFI CLKNTSEQDQ PMGGWEMIRK IGDSSVTYKY
SSRYVLKAGQ TVTIWAANAG VTASPPTDLI WKNQNSWGTG EDVKVILKNS QGEEVAQRST
VFKTTLPEEE EEEEEGKKEV IEAVEEENVS RQQGDLRTSK RSCAIM
//
