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Database: UniProt
Entry: G3WHC9_SARHA
LinkDB: G3WHC9_SARHA
Original site: G3WHC9_SARHA 
ID   G3WHC9_SARHA            Unreviewed;      2696 AA.
AC   G3WHC9;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   22-NOV-2017, entry version 39.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor type 1 {ECO:0000313|Ensembl:ENSSHAP00000014834};
GN   Name=ITPR1 {ECO:0000313|Ensembl:ENSSHAP00000014834};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000014834, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000014834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000014834}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000014834}.
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DR   EMBL; AEFK01084617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084618; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084619; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084620; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01084625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000014834; -.
DR   Ensembl; ENSSHAT00000014959; ENSSHAP00000014834; ENSSHAG00000012663.
DR   eggNOG; KOG3533; Eukaryota.
DR   eggNOG; ENOG410XR97; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G3WHC9; -.
DR   OMA; DPDDHYQ; -.
DR   OrthoDB; EOG091G00T2; -.
DR   TreeFam; TF312815; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005955; C:calcineurin complex; IEA:Ensembl.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005637; C:nuclear inner membrane; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0031088; C:platelet dense granule membrane; IEA:Ensembl.
DR   GO; GO:0031094; C:platelet dense tubular network; IEA:Ensembl.
DR   GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR   GO; GO:0043234; C:protein complex; IEA:Ensembl.
DR   GO; GO:0016529; C:sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0019855; F:calcium channel inhibitor activity; IEA:Ensembl.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0035091; F:phosphatidylinositol binding; IEA:Ensembl.
DR   GO; GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IEA:Ensembl.
DR   GO; GO:0042045; P:epithelial fluid transport; IEA:Ensembl.
DR   GO; GO:0070059; P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; IEA:Ensembl.
DR   GO; GO:0050849; P:negative regulation of calcium-mediated signaling; IEA:Ensembl.
DR   GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0050882; P:voluntary musculoskeletal movement; IEA:Ensembl.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt-bd.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 6.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2220   2242       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2254   2272       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2278   2304       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2341   2366       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2386   2408       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2517   2540       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       58    112       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      119    169       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      177    233       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      240    319       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      325    381       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED     2634   2675       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2696 AA;  307422 MW;  A1BCBBE1BB050EF6 CRC64;
     DCLFKLCPMN RYSAQKQFWK AAKPGANSTT DAVLLNKLHH AADLEKKQNE TENRKLLGTV
     IQYGNVIQLL HLKSNKYLTV NKRLPALLEK NAMRVTLDEA GNEGSWFYIQ PFYKLRSIGD
     SVVIGDKVVL NPVNAGQPLH ASSHQLVDNP GCNEVNSVNC NTSWKIVLFM KWSDNKDDIL
     KGGDVVRLFH AEQEKFLTCD EHRKKQHVFL RTTGRQSATS ATSSKALWEV EVVQHDPCRG
     GAGYWNSLFR FKHLATGHYL AAEVDPDYEE ECLEFQSSMD SDQDTSRSRL RNAQEKMAYS
     LVSVPEGNDI SSIFELDPTT LRGGDSLVPR NSYVRLRHLC TNTWVHSTNI PIDKEEEKPV
     MLKIGTSPVK EDKEAFAIVP VSPAEVRDLD FANDASKVLG SIAGKLEKGT ITQNERRSVT
     KLLEDLVYFV TGGTNSGQDV LEVVFSKPNR ERQKLMREQN ILKQIFKLLQ APFTDCGDGP
     MLRLEELGDQ RHAPFRHICR LCYRVLRHSQ QDYRKNQEYI AKQFGFMQKQ IGYDVLAEDT
     ITALLHNNRK LLEKHITAAE IDTFVSLVRK NREPRFLDYL SDLCVSMNKS IPVTQELICK
     AVLNPTNADI LIETKLVLSR FEFEGVSTGE NPLEAGEDEE EVWLFWRDSN KEIRSKSVRE
     LAQDAKEGQK EDRDVLSYYR YQLNLFARMC LDRQYLAINE ISGQLDVDLI LRCMSDENLP
     YDLRASFCRL MLHMHVDRDP QEQVTPVKYA RLWSEIPSEI AIDDYDSSGT SKDEIKERFA
     QTMEFVEEYL RDVVCQRFPF SDKEKNKLTF EVVNLARNLI YFGFYNFSDL LRLTKILLAI
     LDCVHVTTIF PISKMAKGEE NKGSNVMRSI HGVGELMTQV VLRGGGFLPM TPMAAAPEGN
     VKQTEPEKED IMVMDTKLKI IEILQFILNV RLDYRISCLL CIFKREFDES NSQTSETSSG
     SSNQEGPSNV PGALDFEHIE EQAEGIFGGS EENTPLDLDD HGGRTFLRVL LHLTMHDYPP
     LVSGALQLLF RHFSQRQEVL QAFKQVQLLV TSQDVDNYKQ IKQDLDQLRS IVEKSELWVY
     KGQGPDETMD GASGENEHKK TEEGNNKSQK HESTSSYNYR VVKEILIRLS KLCVQESASV
     RKSRKQQQRL LRNMGAHAVV LELLQIPYEK AEDTRMQEIM KLAHEFLQNF CAGNQQNQAL
     LHKHINLFLN PGILEAVTMQ HIFMNNFQLC SEINERVVQH FVHCIETHGR NVQYIKFLQT
     IVKAEGKFIK KCQDMVMAEL VNSGEDVLVF YNDRASFQTL IQMMRSERDR MDENSPLMYH
     IHLVELLAVC TEGKNVYTEI KCNSLLPLDD IVRVVTHEDC IPEVKIAYIN FLNHCYVDTE
     VEMKEIYTSN HMWKLFENFL VDICRACNNT SDRKHADSIL EKYVTEIVMS IVTTFFSSPF
     SDQSTTLQTR QPVFVQLLQG VFRVYHCNWL MPSQKASVES CIRVLSDVAK SRAIAIPVDL
     DSQVNNLFLK SHNIVQKTAM NWRLSARNAA RRDSVLAASR DYRNIIERLQ DIVSALEDRL
     RPLVQAELSV LVDVLHRPEL LFPENTDARR KCESGGFICK LIKHTKQLLE ENEEKLCIKV
     LQTLREMMTK DRGYGEKLIS IDESDNTELP QPPETENSVE EVDQSLPLRQ LEDHKRGEAL
     RQILVNRYYG NIRPAGRRES LTSFGNGPLS PGGPSKAGGG GGSSGSSTMS RGEMSLADVQ
     CHLDKEGASN LVIDLIMNAS SDRVFHESIL LAIALLEGGN TTIQHSFFCR LTEDKKSEKF
     FKVFYDRMKV AQQEIKATVT VNTSDLGNKK KDDDPDRDAP SRKRAKEPST QITEEVRDQL
     LEATAATRKA FTTYRREADP EDHFPSGEGG TQATPDKPKD DLEMSAVITI MQPILRFLQL
     LCENHNRDLQ NFLRCQNNKT NYNLVCETLQ FLDCICGSTT GGLGLLGLYI NEKNVALINQ
     TLESLTEYCQ GPCHENQNCI ATHESNGIDI ITALILNDIN PLGKKRMDLV LELKNNASKL
     LLAIMESRHD SENAERILYN MRPKELVEVI KKAYMQGEVE FEDAENGEDV AASPRNVGHN
     IYILAHQLAR HNKELQNMLK PGGQVEGDEA LEFYAKHTAQ IEIVRLDRTM EQIVFPVPSI
     CEFLTKESKL RIYYTTERDE QGSKINDFFL RSEDLFNEMN WQKKLRAQPV LYWCSRNMSF
     WSSISFNLAV LMNLLVAFFY PFKGVRGGTL EPHLSGLLWT AMLISLAIVI ALPKPHGIRA
     LIASTILRLI FSVGLQPTLF LLGAFNVCNK IIFLMSFVGN CGTFTRGYRA MILDVEFLYH
     LLYLLICAMG LFVHEFFYSL LLFDLVYREE TLLNVIKSVT RNGRSIILTA VLALILVYLF
     SIVGYLFFKD DFILEVDRLP NETSLPDTSE SLAGEFLYSD VCRLGAGENC SSPVSTEAEL
     TPAEQIEEDK EHTCETLLMC IVTVLSHGLR SGGGVGDVLR KPSKEEPLFA ARVIYDLLFF
     FMVIIIVLNL IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVTFEEHIKE
     EHNMWHYLCF IVLVKVKDST EYTGPESYVA EMIKERNLDW FPRMRAMSLV SSDSEGEQNE
     LRNLQEKLES TMKLVTNLSG QLSELKDQMT EQRKQKQRIG LLGHPPHMNV NPQQPA
//
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