ID G3WHQ5_SARHA Unreviewed; 385 AA.
AC G3WHQ5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Homocysteine inducible ER protein with ubiquitin like domain 1 {ECO:0000313|Ensembl:ENSSHAP00000014960.2};
GN Name=HERPUD1 {ECO:0000313|Ensembl:ENSSHAP00000014960.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000014960.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000014960.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000014960.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003757321.1; XM_003757273.2.
DR RefSeq; XP_012409293.1; XM_012553839.1.
DR RefSeq; XP_012409294.1; XM_012553840.1.
DR AlphaFoldDB; G3WHQ5; -.
DR STRING; 9305.ENSSHAP00000014960; -.
DR Ensembl; ENSSHAT00000015085.2; ENSSHAP00000014960.2; ENSSHAG00000012764.2.
DR eggNOG; KOG4583; Eukaryota.
DR GeneTree; ENSGT00390000017671; -.
DR HOGENOM; CLU_058243_0_0_1; -.
DR TreeFam; TF324319; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd17118; Ubl_HERP1; 1.
DR InterPro; IPR039751; HERPUD1/2.
DR InterPro; IPR000626; Ubiquitin-like_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR12943:SF7; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 1 PROTEIN; 1.
DR PANTHER; PTHR12943; HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UNIQUITIN-LIKE DOMAIN HERPUD PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF00240; ubiquitin; 1.
DR SMART; SM00213; UBQ; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50053; UBIQUITIN_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT DOMAIN 6..67
FT /note="Ubiquitin-like"
FT /evidence="ECO:0000259|PROSITE:PS50053"
FT REGION 89..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 312..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 385 AA; 43307 MW; 2A338525A0F3D13A CRC64;
MESEPVTLLV KSPNQRHRDL ELSGDLNWSV GRLKAHLSRV YPERPREEDQ RLIYSGKLLL
DHLYLRDILP KHEKRHVLHL VCSIRNPSKM PEKISESSEQ PTGLNQDQHS SVDSLSSGLR
QRDVLHNPSS LAWENNSRME AIQQTFQGVS PGFSGYTTYG WLQLSWFQQI YARQYYMQYL
AATAASGAFT SSPSAQEIPV VSTPTPAPIH NQFPAENQPG NQNAAAQVVV NPGANQNLRM
NAQGGPLVEE DDEMNRDWLD WIYSATTFSV FLSILYFYSS LSRFLMVMGA TLVMYLHHVG
WFPFRQRPAP QIPNNMPPRV PINQDPNNNL QEENADGDGE PGLVPPQQDL LEGQQGSPSI
MSTAWLVFKT FFASLLPEGP PAVVN
//
