GenomeNet

Database: UniProt
Entry: G3WI54_SARHA
LinkDB: G3WI54_SARHA
Original site: G3WI54_SARHA 
ID   G3WI54_SARHA            Unreviewed;      1834 AA.
AC   G3WI54;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 40.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1I {ECO:0000313|Ensembl:ENSSHAP00000015109};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015109, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000015109}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000015109}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000015109}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AEFK01190943; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190944; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190945; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190947; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190948; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AEFK01190952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000015109; -.
DR   Ensembl; ENSSHAT00000015235; ENSSHAP00000015109; ENSSHAG00000012891.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G3WI54; -.
DR   OMA; SPSVNCT; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:InterPro.
DR   GO; GO:0070509; P:calcium ion import; IEA:InterPro.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   GO; GO:0030431; P:sleep; IEA:Ensembl.
DR   InterPro; IPR030162; CACNA1I.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF258; PTHR10037:SF258; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   1834       Voltage-dependent T-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003458982.
FT   TRANSMEM     42     61       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    134    152       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    266    288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    300    320       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    491    517       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    537    554       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    667    685       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    705    723       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    788    810       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    866    888       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1267   1288       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1300   1329       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1364   1386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1466   1490       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1559   1582       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1603   1624       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1702   1721       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1788   1810       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    330       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      666    894       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1227   1500       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1567   1820       Ion_trans. {ECO:0000259|Pfam:PF00520}.
SQ   SEQUENCE   1834 AA;  207454 MW;  5E63608772BEF6BC CRC64;
     WFECVSMLVI LLNCVTLGMY QPCEDMDCLS DRCKILQVFD DFIFIFFAME MVLKMVALGI
     FGRKCYLGDT WNRLDFFIVM AGMVEYSLDL QNINLSAIRT VRVLRPLKAI NRVPRRGQMG
     TLRLPVIPLA ANPAFNMLCK FIIFIAGIAG VSRWKTDQAR SLCWTPIQFS LPLKAHLHTH
     TQTETETETE TETGRERETE TDSLGATRSG DGGTSEPCPM GLQAQQDLVF EKCINWPPGP
     LHRLCPGGAH EPFPESLEKD FEGLKYLFLG IDYLSLTLSF LVSLWVSVLD FVSLKSLCMY
     ISLFLVGSFF MINLCLVVIA TQFSETKQRE HQLMQEQRRR YLSSSTVASY AEPGDCYEEI
     FQYVCHILRK AKRRSLGLYH ALRSRHQGQV EPGVGAKPEA GSAKEPRRDS KCWGGEASSR
     SPDHSLRKIA YYDRKWWRRG RKEGRCDHRQ GRKRDKKKKK KKKKKNPPKD PQTSFLPSFL
     PSFLPSFLPP FLLSFLPPSL PLSLTPFLLF SLLSFLIANK MPTPPKDEEC DLVENSLSFV
     LFILTFPLGP FGNYHKKFIK KHIPLDYPSH TLVQPISVTQ TSDPGNCPHC QQERDQRLSL
     AESDDDFGRE EGSANDDEGE GGGSSEGTLD LEKEEEEGEK GSGAASLCGD IWREVRAKLR
     GIVDSKYFNR GIMIAILVNT VSMGIEHHEQ PEELTNILEI SNVVFTSMFA LEMILKLAAF
     GLFDYLRNPY NIFDSIIVII SIWEIIGQSD GGLSVLRTFR LLRVLKLVRF MPALRRQLVV
     LMKTMDNVAT FCMLLMLFIF IFSILGMHIF GCKFSLKTDT GDTVPDRKNF DSLLWAIVTV
     FQILTQEDWN MVLYNGMAST SPWASLYFVA LMTFGNYVLF NLLVAILVEG FQAETLWSSL
     EALASLLPSL PTPGDDRNGD ANRSYSDEDQ SSSNMGSERG MKAILVRDAL PAHVGDPHQS
     RPDLALAHSF SPQARRGKTL TGGEGPAALG PDHLAARSLS PGSAPFGLSE EMQSSSRSSY
     YGAWGHSGAW ASRRSSWNSL ARGHSLKHRA PSAEHESLLS GERGQSAEGE RDDSAPRGPS
     HHLPPHTHPH PHHHHLHHPH RYRHRRTLSL DTKDSLDLAE LPLPAPHAHL RSTRKVGSGL
     GASEHQDCNG KMPNIAKDVF TKMDNRKDHA EDEEEIDYEA HLKEIEGIRK MIDVYKPDWC
     EIREDWSVYL FSPENRFRVL CQTIITHKLF DYVVLAFIFL NCITIALERP QIEAGSTERI
     FLTVSNYIFT AIFVGEMTLK VVSLGLYFGE QAYLRSSWNI LDGFLVFVSL IDIVVSVASA
     GGATILGVLR VLRLLRTLRP LRVISRAPGL KLVVETLISS LKPIGNIVLI CCAFFIIFGI
     LGVQLFKGKF YHCLGVDIRN ITNRSDCMAA NYRWVHHKYN FDNLGQQALM SLFVLASKDG
     WVNIMYNGLD AVAVDQQPVT NHNPWMLLYF ISFLLIVSFF VLNMFVGVVV ENFHKCRQHQ
     EAEEARRREE KRLRRLEKKR RTCLLIHGLS SLRVGPLPFA SAEAQRLPYY ATYCPTRLLI
     HSVCTSHYLD IFITFIICLN VVTMSLEHYN QPMSLEIALK YCNYMFTTVF VLEAMLKLVA
     FGLRRFFKDR WNQLDLAIVL LSVMGITLEE IEINAALPIN PTIIRIMRVL RIARVLKLLK
     MATGMRALLD TVVQALPQVG NLGLLFMLLF FIYAALGVEL FGKLVCSDEH PCEGMSRHAT
     FENFGMAFLT LFQVSTGDNW NGIMKDTLRD CTHDERSCLS NLQFISPLYF VSFVLTAQFV
     LINVVVAVLM KHLDDSNKEA QEDAEMDAEI ELEM
//
DBGET integrated database retrieval system