ID G3WII6_SARHA Unreviewed; 766 AA.
AC G3WII6;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=BRCA1 associated RING domain 1 {ECO:0000313|Ensembl:ENSSHAP00000015241.2};
GN Name=BARD1 {ECO:0000313|Ensembl:ENSSHAP00000015241.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015241.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000015241.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000015241.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G3WII6; -.
DR STRING; 9305.ENSSHAP00000015241; -.
DR Ensembl; ENSSHAT00000015368.2; ENSSHAP00000015241.2; ENSSHAG00000012998.2.
DR eggNOG; KOG0504; Eukaryota.
DR eggNOG; KOG4362; Eukaryota.
DR GeneTree; ENSGT00940000156532; -.
DR HOGENOM; CLU_021642_0_0_1; -.
DR TreeFam; TF326440; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd17734; BRCT_Bard1_rpt1; 1.
DR CDD; cd17720; BRCT_Bard1_rpt2; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039503; BARD1_Znf-RING.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR24171; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR PANTHER; PTHR24171:SF8; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF14835; zf-RING_6; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SMART; SM00292; BRCT; 2.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF52113; BRCT domain; 2.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT REPEAT 415..447
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 448..480
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 481..513
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 559..642
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 656..766
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 78..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 236..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 356..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 766 AA; 85551 MW; 30A9412F67F302AE CRC64;
MEGKIIIFKS CGINILREPV CLGGCEHIFC STCVSDCIGA ECPVCHTPAW IQDVKINRQL
DNMIQLCSKL RNLLHNSSGT DLEESTSGTR TSPDEGENDK KFIKMWFSPR SKKVRYVLNK
TSVQTQPQPV EDEQVYQAFE FTSSSLEQDS PQKPKKVSRK SRKKQKKRSL AEINQEWNLE
DENQKEVQEF DQSISEKLKE KSVSFCFQPS VLETPDLNGG GIDLLSYVSM TEASPAEKAD
EVCPSSTPQV DSVETERESE IASSFGDSLG ENSFVPETLL SLNNGRTTER QPSDSFMVPL
SKRPRRRSQQ RARRTSVNQD ILTELLLPSK ENAASPKSKC VVDDPSLKAR NSDVLNDSIS
FSPSKSSSTP SSSIMNSPSQ SWIVASPSAM KLSPTSPSTG KLSPTSPVII KRNHRGETPL
HIASIKGDVP SVEYLLQNGS DPNVKDHAGW TPLHEACNHG HQKVVELLLQ HKALVNTTGY
QNDSPLHDAV RNGHVSIAKL LLFHGASRNA VNIFGLRPVD YAETEAMRSV LSLPEESKIY
KSRHCSGPVN TSQRRDDPVI LLSSGLNSDQ QKLLSELVAV LKAKKYTEFN STVTHIIVPG
DTVQRTMKCI LGIISGCWIL KFDWVKACLE SRMCEPEEKY EMPGGPQRSR LNREQLLPKL
FDGCYFYFEG TFKHHSKDEL IKLAKASGGQ ILNRKPKPDS DVTQTINTVS YHARPDSDQR
FCTQYIIYDA FSNYCPQKIR QGKVWMAPSS WFIDCLVSFQ VLPVAK
//
