ID G3WJ00_SARHA Unreviewed; 1021 AA.
AC G3WJ00;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Pleckstrin homology and RUN domain containing M1 {ECO:0008006|Google:ProtNLM};
GN Name=PLEKHM1 {ECO:0000313|Ensembl:ENSSHAP00000015405.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000015405.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000015405.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000015405.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003768484.1; XM_003768436.2.
DR AlphaFoldDB; G3WJ00; -.
DR STRING; 9305.ENSSHAP00000015405; -.
DR Ensembl; ENSSHAT00000015532.2; ENSSHAP00000015405.2; ENSSHAG00000013130.2.
DR eggNOG; KOG1829; Eukaryota.
DR GeneTree; ENSGT00940000155111; -.
DR HOGENOM; CLU_011318_0_0_1; -.
DR InParanoid; G3WJ00; -.
DR TreeFam; TF317067; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0044754; C:autolysosome; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0061909; P:autophagosome-lysosome fusion; IEA:Ensembl.
DR GO; GO:1902774; P:late endosome to lysosome transport; IEA:Ensembl.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; IEA:Ensembl.
DR CDD; cd00821; PH; 1.
DR CDD; cd17679; RUN_PLEKHM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047326; RUN_PLEKHM1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 41..183
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 499..590
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 648..742
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 951..1005
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 209..236
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 364..442
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 595..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 290..304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1021 AA; 114661 MW; 50F90F0C703CDB4D CRC64;
MLSTVENGLD PKAPIPVIKK KLVGSVKALQ KQYAASDAVV TSEDGEANVM CSALEAVFIH
GLQAKYIKAD AGGKRKKKGG QTPLPQPAFW PLLKTITHRN TITDLEHLTF INTDVGRCRA
WLRLALNDGL MECYLKLLLQ EKSQLCKYYQ PTALLLDPEE SEIFLSLLQG LTSLSFELSY
KSAILNEWTL TPLALSGLCP LSELDSPPGG AELHRKKSLD SISQSSGSED IEVQHSSSKI
RCGMKLTSSS LSLNTASSSQ LSCSLNSDSC LLQENGARSP ARSEDPMSCD SDLGTANTFD
SDRSLQDPTV HLHLDGSAGL LTAPRCPLDI THKQVPISLV SSALRLPQTF LIDIDHAGRS
SSLQLHSTKD DTHTSCVSNG QETSREHDSS EIDYYLASSA PSPESKSWIS EDDFYRPSPE
RIPDSASDLS GGGTPETRPS DIHSLASEEP MKNQIMGPSD QTCIPSLEAR PTKPISDPEY
KHFWVVHRRQ IGLYNPFRGL IKLGTLERRG AMGIWKEFFC ELAPLEFRLY LNDEDRECVE
NCSLLRCESV GPAQSDGRFE VVFSNKKLTL RAPCQDEAED WLDRLHEALQ KCRPQQEQEW
ETLQPPDPLE ELEHPQGSSF SQPIPAFQEE ASLGGHFDWP FPLMPELDAI KESILYMHTE
KTWTPLIFSL SLESLKCFKM RNNEKILSDS HGIETIRDIL PDTSLGSPAF FKIITAKATL
KLKAQNAEEA TAWRELVRKV LTSYLETAEE ALTLGGSLDE NSQEILRYTT GKNGFLLQYL
VAIPTEKGLD SQSFFCAGCS RQIGFSFVRP KLCAFSGLYY CDICHQDDNS VIPARLIHNW
DLTKRTVCRQ ALKFLIQIRN QPLINLQLVN KSLYDHVERM NHIWRSREQL KLLGDYLILC
RSGALKELSK RLNHRNYLLE SPHKYSVADL QQIADGSFEG FLQDLIQYAS QHVYHCDLCT
QRGFICQICH HNGIIFPFEF DTTTRCRECK TVFHSSCQTQ MKNGCPRCAR RKKYQEQSLY
T
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