GenomeNet

Database: UniProt
Entry: G3WLK3_SARHA
LinkDB: G3WLK3_SARHA
Original site: G3WLK3_SARHA 
ID   G3WLK3_SARHA            Unreviewed;       545 AA.
AC   G3WLK3;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   07-APR-2021, sequence version 2.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=HMG box domain-containing protein {ECO:0000259|PROSITE:PS50118};
GN   Name=TOX2 {ECO:0000313|Ensembl:ENSSHAP00000016308.2};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016308.2, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000016308.2, ECO:0000313|Proteomes:UP000007648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA   Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA   Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA   Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA   Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA   Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered marsupial
RT   Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000016308.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; G3WLK3; -.
DR   STRING; 9305.ENSSHAP00000016308; -.
DR   Ensembl; ENSSHAT00000016443.2; ENSSHAP00000016308.2; ENSSHAG00000013874.2.
DR   eggNOG; KOG0381; Eukaryota.
DR   GeneTree; ENSGT00940000158764; -.
DR   HOGENOM; CLU_030650_2_0_1; -.
DR   InParanoid; G3WLK3; -.
DR   OrthoDB; 4252846at2759; -.
DR   TreeFam; TF106481; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   CDD; cd21995; HMG-box_TOX-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR45781; AGAP000281-PA; 1.
DR   PANTHER; PTHR45781:SF5; TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 2; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PRINTS; PR00886; HIGHMOBLTY12.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648}.
FT   DOMAIN          276..344
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        276..344
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          213..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          348..438
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          464..526
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        213..239
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..261
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        348..363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        364..382
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..437
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..480
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        481..520
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   545 AA;  59127 MW;  C979F363387192C3 CRC64;
     MDVRFYPAAP TAVGALPGAD PTCLGHLDYY HCNKFDGENM YMGMNEANQE FLSANQPSTS
     LTKASVGGNL LTNLSSSAHK LPRERTYNGQ SENNEDYEIP PITPPNLPDP SLLHLVDHET
     GYHSLCHSLP PNSLIPTYSY QNMDLPAIMV SNMLTQDGHL LSSQLPTIQE MVHAEASSYD
     STRQVSLLNR PTMLASHMSA LSQSQLISQM GIRSGVSHGS PSPPGSKSAT PSPSSSTQEE
     ETEAHYKVTG EKRPSADLGK KPKSQKKKKK KDPNEPQKPV SAYALFFRDT QAAIKGQNPN
     ATFGDVSKIV ASMWDSLGEE QKQAYKRKTE AAKKEYLKAL AAYRASLVSK SSAEQTEAKT
     TPPNPPSKMI PPKQPMYSIP PQASSPYPGL GSFLSPSDLQ GYRGHPHPSL SRTLNSKSML
     PSISASPPPP PPSFQISPPL HQQLALHHPQ SAILNQSLTM QPVPQQSILS PPPMALQVQP
     PMSTSPPGQQ DFSHISPEFQ SSVGSCSPGT SNTPGNSDWD SDYPNRECGI NHCSMLPRDK
     SLYLT
//
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