ID G3WLY8_SARHA Unreviewed; 408 AA.
AC G3WLY8;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 16-NOV-2011, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=tRNA N(3)-methylcytidine methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
DE EC=2.1.1.- {ECO:0000256|PIRNR:PIRNR037755};
GN Name=METTL8 {ECO:0000313|Ensembl:ENSSHAP00000016443.1};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016443.1, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000016443.1, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000016443.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase.
CC {ECO:0000256|PIRNR:PIRNR037755}.
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. METL family.
CC {ECO:0000256|ARBA:ARBA00009725, ECO:0000256|PIRNR:PIRNR037755}.
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DR RefSeq; XP_003764011.1; XM_003763963.2.
DR AlphaFoldDB; G3WLY8; -.
DR STRING; 9305.ENSSHAP00000016443; -.
DR Ensembl; ENSSHAT00000016580.2; ENSSHAP00000016443.1; ENSSHAG00000013987.2.
DR GeneID; 100930691; -.
DR KEGG; shr:100930691; -.
DR CTD; 79828; -.
DR eggNOG; KOG2361; Eukaryota.
DR GeneTree; ENSGT00940000159683; -.
DR HOGENOM; CLU_029724_0_2_1; -.
DR InParanoid; G3WLY8; -.
DR OMA; MFLFRDY; -.
DR OrthoDB; 5471626at2759; -.
DR TreeFam; TF323232; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0008174; F:mRNA methyltransferase activity; IEA:Ensembl.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR013217; Methyltransf_12.
DR InterPro; IPR026113; METTL2/6/8-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR22809; METHYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR22809:SF3; TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL8, MITOCHONDRIAL; 1.
DR Pfam; PF08242; Methyltransf_12; 1.
DR PIRSF; PIRSF037755; Mettl2_prd; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|PIRNR:PIRNR037755};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transferase {ECO:0000256|PIRNR:PIRNR037755};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694}.
FT DOMAIN 202..306
FT /note="Methyltransferase type 12"
FT /evidence="ECO:0000259|Pfam:PF08242"
SQ SEQUENCE 408 AA; 46620 MW; CAB32A61045BC416 CRC64;
MNAVQILLAS RLMKRRILIR FQSNDRPTVP LGSRILTDPA KVYEHNMWDH IEWTEEEEAI
AREKTTENSS VKVQLEDQVK YESQASKYWN NFYKTHKNKF FKDRNWLLRE FPEILPFGLQ
TKEEKGKLSW DHVKTNATDS FSKIHCPALP KGVESCKNDS VGDCAYSQSE ISSGDNQHTK
KKRREAAKTQ LFPGSHATFR ILEVGCGAGN SVFPILNALK NAPETFLYCC DFASGAVELV
KSHSAYSPAQ CSAFVHDVCD DGLSYPFPDG ILDVILLVFV LSSIHPDRMQ GVVNRLSKLL
RPGGMLLFRD HGRYDLTQLR FKKGCCLSEN FYVRGDGTRA YFFTKGEVHD MFHQAGLDEK
QNLIDRRLQV NRKEKVRMHR VWIQGKFQKP LHSFHNDSDD LIPGVSAG
//
