ID G3WLZ9_SARHA Unreviewed; 1039 AA.
AC G3WLZ9;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Toll like receptor 8 {ECO:0000313|Ensembl:ENSSHAP00000016454.2};
GN Name=TLR8 {ECO:0000313|Ensembl:ENSSHAP00000016454.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000016454.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000016454.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000016454.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_003765627.2; XM_003765579.2.
DR RefSeq; XP_012401535.1; XM_012546081.1.
DR AlphaFoldDB; G3WLZ9; -.
DR STRING; 9305.ENSSHAP00000016454; -.
DR Ensembl; ENSSHAT00000016591.2; ENSSHAP00000016454.2; ENSSHAG00000013998.2.
DR GeneID; 100923069; -.
DR KEGG; shr:100923069; -.
DR CTD; 51311; -.
DR eggNOG; KOG4641; Eukaryota.
DR GeneTree; ENSGT00940000160879; -.
DR HOGENOM; CLU_006000_2_0_1; -.
DR InParanoid; G3WLZ9; -.
DR TreeFam; TF351113; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0007249; P:canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0071260; P:cellular response to mechanical stimulus; IEA:Ensembl.
DR GO; GO:0051607; P:defense response to virus; IEA:Ensembl.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0032695; P:negative regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0032727; P:positive regulation of interferon-alpha production; IEA:Ensembl.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0032757; P:positive regulation of interleukin-8 production; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0001932; P:regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0034158; P:toll-like receptor 8 signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR47410; TOLL-LIKE RECEPTOR 7-RELATED; 1.
DR PANTHER; PTHR47410:SF1; TOLL-LIKE RECEPTOR 8; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01582; TIR; 1.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 16.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 3.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..1039
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030171908"
FT TRANSMEM 826..848
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 878..1022
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1039 AA; 119944 MW; 0489A76910B68652 CRC64;
MVTMILQSLN FICLCFLVIC SPELLDQKVN LRDYPCSIKR QNSSVIANCL ACRLHSVPKS
LDHNVTEIDL SFNFIKNITS ESFVGLNNLT KINLNSNTNS QVEDRNFMKI SDGAFFNLTN
LKELLLEDNH LQKIPIHLPP SLTTISLVLN NIYHITKNCT SGLIQLKSLY LGWNCFYGNE
CKKNVLIDDG AFEDLANLTV LSLSFNNLSH VPTKLPPSLN ELYLSNNKIK NISQDDFKNL
GNLRVLDLSG NCPRCFNNPY PCTPCENSAS IQIHPDAFQN LGQLTHLNLS STSLKSLPAS
WFSNMTNLEV LLLEFNYLVK EIATGDFFTK LPKLEILDFS YNYLKNSYPQ YIVISGNFSK
LVSLKTLHLK GYVFQELRKE DFQPLTKLQN LQSINLGINF INHIDFTLFE EFNNLSLIYL
SENRISPQVT NSLGEKSNSL SFTNHVIHQR SIDSDNEPLG HYEIDPHRNF YHHTYPLMKP
ECTSYGKALD LSLNSIFFVN HNLFEGLHDI VCLNLSSNGN AQVLNGSEFS SINRTKYLDL
SHNRLDFDDD GAFQELRELE VLDLSNNEHY FRIAGVTHRL GFIQNLPQLK VLNLSQNGIF
TLTENQLISK SLKELVFKGN RLDILWKKED KRYLAIFKEL SNLTLLDLSI NRLHRIPNEA
FLNLPHSLEE LRLNNNHLSI FNWTSLQYFH SLRVLDLQSN SLSTINFDLS NSSLKILLLG
KNRISHLPDD LLSKAKGLYQ LDLSYNHIKM INKSTFQMKA SNHLKILELR GNPFDCTCEI
RDFRKWMDEN LNVTIPKLVE VTCSTPGDQM GKSIMELELN TCISDVIAAI FFFFSFIITV
SSMVIATFHH LFYWDIWYIY HLCSAKIKGY KSVSTSKTFY DAFIAYDTKD TCVTDWVINE
LRFQLEENEE KKVLLCLEER DWDPGIAIID NLMQSINQSK KTIFVLTKKY AKNWNFKTAF
YLALQRLMDD NMDVIIFILL EPVLQHSQYL RLRRRICKSS VLKWPDNPKA EELFWQSLKN
VVLTDNDTRY NNLYVKFIK
//
