GenomeNet

Database: UniProt
Entry: G3WPK8_SARHA
LinkDB: G3WPK8_SARHA
Original site: G3WPK8_SARHA 
ID   G3WPK8_SARHA            Unreviewed;       782 AA.
AC   G3WPK8;
DT   16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT   16-NOV-2011, sequence version 1.
DT   27-SEP-2017, entry version 29.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   Name=ATP6V0A2 {ECO:0000313|Ensembl:ENSSHAP00000017363};
OS   Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX   NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017363, ECO:0000313|Proteomes:UP000007648};
RN   [1] {ECO:0000313|Ensembl:ENSSHAP00000017363}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA   Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E.,
RA   Miller J., Walenz B., Knight J., Qi J., Zhao F., Wang Q.,
RA   Bedoya-Reina O.C., Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A.,
RA   Woodbridge P., Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S.,
RA   Helgen K.M., Lesk A.M., Pringle T.H., Patterson N., Zhang Y.,
RA   Kreiss A., Woods G.M., Jones M.E., Schuster S.C.;
RT   "Genetic diversity and population structure of the endangered
RT   marsupial Sarcophilus harrisii (Tasmanian devil).";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN   [2] {ECO:0000313|Ensembl:ENSSHAP00000017363}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSSHAP00000017363}.
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DR   EMBL; AEFK01067357; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9305.ENSSHAP00000017363; -.
DR   Ensembl; ENSSHAT00000017508; ENSSHAP00000017363; ENSSHAG00000014753.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   GeneTree; ENSGT00390000004941; -.
DR   InParanoid; G3WPK8; -.
DR   OMA; TIPSFMN; -.
DR   OrthoDB; EOG091G01BI; -.
DR   TreeFam; TF300346; -.
DR   Proteomes; UP000007648; Unassembled WGS sequence.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
DR   GO; GO:0036295; P:cellular response to increased oxygen levels; IEA:Ensembl.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000007648};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    367    391       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    412    430       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    514    532       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    544    567       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    579    600       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    612    634       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    714    734       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    746    768       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       55     89       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   782 AA;  89367 MW;  704FC2186BE5CF72 CRC64;
     LNQNVSAFQR KFVGEVKRCE ELERILAYLV QEIKKADIPL PDGDTSPPAP PFKQVLEMQE
     QLQKLEVELR EVTKNKEKLR KNLLELIEYT HMLRVTKTFV KRNIEFEPSY EEFPSLEKDS
     LLDYNCMQRL GAKLGFVSGL IHQTKVEAFE KMLWRVCKGY TIVTHAELDE CLEDPETGDV
     TKWYVFLISF WGDQIGQKVK KICDCYHCHV YPYPSTVEER KEVHEGLNTR IQDLYTVLHK
     TEDYLRQVLS KAAESVCTRV VQVQKMKAIY HTLNMCSFDV TNKCLIAEVW CPEADLHNLR
     QALLEGSRES GVTIPSFMNT IPTTETPPTL IRTNKFTEGF QNIVDAYGVG SYREVNPALY
     TIITFPFLFA VMFGDFGHGF LMFLFALLLV LNENHPRLKH SQDEIMKMFF DGRYVILLMG
     LFSVYTGLIY NDCFSKSVNL FGSGWNVSAM FKSTLDDTNT SGHWNDNDIK ANAFLQLDPD
     TTGVFQGAYP FGIDPIWNLA TNRLSFLNSF KMKMSVIFGV THMTFGVVLG IFNHLHFKKK
     FNIYLVCLPE LLFMLCIFGY LIFMIIYKWL TYSAANSRLA PSILIEFINM FLFPSGGAAS
     GLYQGQSHVQ KFLLVVAAVS VPVLFLGKPL YLLWLHNGGR LFGLHKSGYT LVRKDSEEDV
     CLLGSQNVEE GISHFEGEGR KDEEEFNFGE IFMAQAIHAI EYCLGCISNT ASYLRLWALS
     LAHAQLSEVL WAMIMRVGLR VDRTYGVLLL IPLVALFAVL TILILLVMEG LSAFLHAIRL
     HW
//
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