ID G3WPW5_SARHA Unreviewed; 719 AA.
AC G3WPW5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Sulfate anion transporter 1 {ECO:0000256|RuleBase:RU362052};
DE AltName: Full=Solute carrier family 26 member 1 {ECO:0000256|RuleBase:RU362052};
GN Name=SLC26A1 {ECO:0000313|Ensembl:ENSSHAP00000017470.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000017470.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000017470.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000017470.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Sodium-independent sulfate anion transporter. Can transport
CC other anions including bicarbonate, thiosulfate and oxalate.
CC {ECO:0000256|RuleBase:RU362052}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362052}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362052}.
CC -!- SIMILARITY: Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
CC {ECO:0000256|RuleBase:RU362052}.
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DR RefSeq; XP_012407874.1; XM_012552420.1.
DR AlphaFoldDB; G3WPW5; -.
DR STRING; 9305.ENSSHAP00000017470; -.
DR Ensembl; ENSSHAT00000017615.2; ENSSHAP00000017470.2; ENSSHAG00000014844.2.
DR GeneID; 105750931; -.
DR KEGG; shr:105750931; -.
DR CTD; 10861; -.
DR eggNOG; KOG0236; Eukaryota.
DR GeneTree; ENSGT01100000263544; -.
DR HOGENOM; CLU_003182_9_4_1; -.
DR InParanoid; G3WPW5; -.
DR TreeFam; TF313784; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008271; F:secondary active sulfate transmembrane transporter activity; IEA:InterPro.
DR CDD; cd07042; STAS_SulP_like_sulfate_transporter; 1.
DR Gene3D; 3.30.750.24; STAS domain; 1.
DR InterPro; IPR018045; S04_transporter_CS.
DR InterPro; IPR011547; SLC26A/SulP_dom.
DR InterPro; IPR001902; SLC26A/SulP_fam.
DR InterPro; IPR002645; STAS_dom.
DR InterPro; IPR036513; STAS_dom_sf.
DR NCBIfam; TIGR00815; sulP; 1.
DR PANTHER; PTHR11814:SF31; SULFATE ANION TRANSPORTER 1; 1.
DR PANTHER; PTHR11814; SULFATE TRANSPORTER; 1.
DR Pfam; PF01740; STAS; 1.
DR Pfam; PF00916; Sulfate_transp; 1.
DR SUPFAM; SSF52091; SpoIIaa-like; 1.
DR PROSITE; PS01130; SLC26A; 1.
DR PROSITE; PS50801; STAS; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|RuleBase:RU362052};
KW Antiport {ECO:0000256|RuleBase:RU362052};
KW Ion transport {ECO:0000256|RuleBase:RU362052};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362052};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362052};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362052}; Transport {ECO:0000256|RuleBase:RU362052}.
FT TRANSMEM 82..103
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 123..146
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 195..214
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 396..417
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 437..470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT TRANSMEM 491..519
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362052"
FT DOMAIN 547..708
FT /note="STAS"
FT /evidence="ECO:0000259|PROSITE:PS50801"
SQ SEQUENCE 719 AA; 78967 MW; 08B689DBBD2DB81B CRC64;
MLVDSMNAPR MDGQAELERT DPGLQIPILI QRQAPPQKSL RETAKASLRK KCSLTPTTLK
DAILGFFPVI GWLPKYRFRE YIVGDIMSGL VIGVILVPQA IAYSLLAGLK PIYSLYTSFF
SNIIYFLMGT SRHVSVGIFS LLCLMVGQVV DRELQLAGFD LNEDVAAAGR NDSNETFPAS
ELPLGGLSPE CGKECYAISI ATALTFLAGV YQVLMGLFRL GFVSTYLSQP LLDGFATGAS
LTILTSQVKY LFGIKLPRYQ GYGMFLATWV NMIRNITQAN VCDVLTSAVC LTVLITAKEL
TERYKKKLRV PLPTELVVIV TATLVSHFGK LHERYGSSIS GDIPTGFIPP QAPSFGLMHR
VALDAVPIAV IGFAFTVSLS EMFAKNYGYT IRANQEMFAV GFCNIIPSFF HCYTTSAALS
KTLVKTSTGC HTQVSSVVSA AVVLLVLLFL APLFYSLQKC VLACIIIVSL KGALWKFRDV
PRQYRVNKTD ALIWCVTMAS CALISIEIGL LVGVLFSVFC VVGRTQHPHV ALLGQIESTV
FYEDNRKYEN LLPIPKIRIF RFEAPLYYAN KDFFLKSLYK MTGLDPTLEA AKRKKCERGK
APMDGGHVGK GALGELGQAD PSCHLVPKQG EFHTIIIDCS SVLFLDTAGI GTLKNVWKDY
KAVNVAILLA GCNPSVTESL RRGGYFGNDD SSMKELLFYN VHGAVQFVRS REQVVDSTL
//
