ID G3WSE5_SARHA Unreviewed; 1310 AA.
AC G3WSE5;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=STK36 {ECO:0000313|Ensembl:ENSSHAP00000018350.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000018350.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000018350.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000018350.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
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DR STRING; 9305.ENSSHAP00000018350; -.
DR Ensembl; ENSSHAT00000018500.2; ENSSHAP00000018350.2; ENSSHAG00000015575.2.
DR eggNOG; KOG0597; Eukaryota.
DR GeneTree; ENSGT00940000158375; -.
DR HOGENOM; CLU_002453_2_0_1; -.
DR InParanoid; G3WSE5; -.
DR TreeFam; TF105340; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0001222; F:transcription corepressor binding; IEA:Ensembl.
DR GO; GO:0035082; P:axoneme assembly; IEA:Ensembl.
DR GO; GO:0007420; P:brain development; IEA:Ensembl.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; IEA:Ensembl.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0045880; P:positive regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0009791; P:post-embryonic development; IEA:Ensembl.
DR GO; GO:0007224; P:smoothened signaling pathway; IEA:Ensembl.
DR CDD; cd14002; STKc_STK36; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22983; PROTEIN KINASE RELATED; 1.
DR PANTHER; PTHR22983:SF6; SERINE_THREONINE-PROTEIN KINASE 36; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 4..254
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 33
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1310 AA; 144004 MW; 45D0D721F90C30AF CRC64;
MEKYHVLEMI GEGSFGRVYK GRKKYSAQVV ALKFIPKLGR SEKELRNLQR EIEIMRGLRH
PNIVQMLDSF ETDKEVVVVT DYAEGELFQI LEDDGKLPED QVQAIAAQLV SALYYLHSHR
ILHRDMKPQN ILLAKGGGIK LCDFGFARAM STNTMVLTSI KGTPLYMSPE LVEERPYDHT
ADLWSVGCIL YELAVGTPPF YTTSIFQLVS LILKDPVRWP PTISQCFKSF LQGLLTKDPR
QRLAWPELLY HPFIAGRVTV TSESVTSDLG TPFTSRLPPE LQVLKEEQAH WLAPKSGQSR
ILRQARKRMT EEARQKKHLN PGLPFEQVDK AGKAVPMTAL LSRLRTTSHD LNLSSGASSP
EDKNEWADWV ASEPPLPTRE PQVTQEYDQQ FPELKREAEE NMNAVNLETE EPDSDNEWQH
LLEPTAPSNF QLKAPLTLLC NPDFCQRVQN QLHGAGGQVL EGILDGASRL LPALRVVKSL
LISCSDSSLL YAFCREAGLP GLLLNLLRHS QSSISIQQQP WCGTFLRDLV ATIQAYFASN
FNLEKSQTGD SLQVFQEAAN LFLNLLGKLL AQPDDAEQTL RRDGLMCFTD LCKTMDGSSL
SISKSFYSSL LTTHRPVLDG LLHGMALPQL PLHTPPGAPQ VSQPLREQDE DLPRAFATAL
AAICTLPVGL PGCWDSKEQV SRYLADQLTE EGSQLRPYLF SSLQHPSLSL HLLKVLYACC
HVSENLCRRL DQEPVALESL LLLVQGKVDV MDPEEAAEAT LHLLSLLVLR LQVLPPGVKK
IGNELAVLFV HSPVVSLVSA AAGLLSQLSQ QGVAFNLQPK EWTAAAAHAL SAPAELRRTP
PGGSGFYDGL LFLLLQLITQ GGAEIVQDVA NSELWTILWH RFFMTLRLSE EVPSSEDKRN
LPSQTIPEPE WTLISPRGIT ALLNLALAVF TQEPHLCLPH LIQHGSILMS TLKHLLSPSF
LQQLGQAPHG SELLPAVVLP VCQLLCFPFA MDVDVDILLS ILTDLRDSEV PANLLQVCCR
YLLLPQAELP VSLLTRLALT DSTTLNQFVA AVAASPNTIT FLSAALLGDQ PLLTSDILSL
LAHAARVWPP THLFFLQDLL AGPDESYWPL RCLLGHPENP VRARAYGLLG HLLHHSTALR
GALQSQAGLL SLLLAGLRDK DPAVRRSASF AVGNAAYQAG PLAAALAPAV PRVTQLLGDP
QTGTRRNAAS ALGNLGPEGL GEELLRCQVP HRLLETACGD PQPTVREAAL IALRSLRQEP
CIHQVLVSLD ASEKLASLSS SGPLPPGSPR PSSARHCKKL IHLLRPAHST
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