ID G3WU27_SARHA Unreviewed; 1039 AA.
AC G3WU27;
DT 16-NOV-2011, integrated into UniProtKB/TrEMBL.
DT 07-APR-2021, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=Integrin subunit alpha 2b {ECO:0000313|Ensembl:ENSSHAP00000018932.2};
GN Name=ITGA2B {ECO:0000313|Ensembl:ENSSHAP00000018932.2};
OS Sarcophilus harrisii (Tasmanian devil) (Sarcophilus laniarius).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Metatheria; Dasyuromorphia; Dasyuridae; Sarcophilus.
OX NCBI_TaxID=9305 {ECO:0000313|Ensembl:ENSSHAP00000018932.2, ECO:0000313|Proteomes:UP000007648};
RN [1] {ECO:0000313|Ensembl:ENSSHAP00000018932.2, ECO:0000313|Proteomes:UP000007648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=21709235; DOI=10.1073/pnas.1102838108;
RA Miller W., Hayes V.M., Ratan A., Petersen D.C., Wittekindt N.E., Miller J.,
RA Walenz B., Knight J., Qi J., Zhao F., Wang Q., Bedoya-Reina O.C.,
RA Katiyar N., Tomsho L.P., Kasson L.M., Hardie R.A., Woodbridge P.,
RA Tindall E.A., Bertelsen M.F., Dixon D., Pyecroft S., Helgen K.M.,
RA Lesk A.M., Pringle T.H., Patterson N., Zhang Y., Kreiss A., Woods G.M.,
RA Jones M.E., Schuster S.C.;
RT "Genetic diversity and population structure of the endangered marsupial
RT Sarcophilus harrisii (Tasmanian devil).";
RL Proc. Natl. Acad. Sci. U.S.A. 108:12348-12353(2011).
RN [2] {ECO:0000313|Ensembl:ENSSHAP00000018932.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; G3WU27; -.
DR STRING; 9305.ENSSHAP00000018932; -.
DR Ensembl; ENSSHAT00000019088.2; ENSSHAP00000018932.2; ENSSHAG00000016072.2.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000160724; -.
DR HOGENOM; CLU_004111_4_1_1; -.
DR InParanoid; G3WU27; -.
DR OrthoDB; 3816176at2759; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000007648; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005925; C:focal adhesion; IEA:Ensembl.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0050840; F:extracellular matrix binding; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR018184; Integrin_alpha_C_CS.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF73; INTEGRIN ALPHA-IIB; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00357; Integrin_alpha; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 4.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS00242; INTEGRIN_ALPHA; 1.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000007648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 32..1039
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5029936927"
FT TRANSMEM 999..1020
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 33..96
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 292..358
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 359..418
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 421..482
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 467..619
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 621..761
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 767..987
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
SQ SEQUENCE 1039 AA; 114382 MW; 53413B7ADDB3454A CRC64;
MVRTHCLLPT LWLLRWIYLL LVLGGVPPAW ALNLDAAQPA FYMGPDGSHF GFALDFYQDD
YGGIGIVVGA PRAVGRPGEA TGGVFLCPWA AKGSNCSTLK FDLDDKNNSV GAITFKTFKA
NQGLGASVVS WKDIIVACAP WQHWNVLELT EEAGKTPVGS CFVAQPKSGR RAEFAPCREN
AMNQLYLGNY VYLGNYRRDL RYCEVGFSST VTQSGELVLG APGGYYFIGL LARAQLSDIM
SSYTTSSLLW TVPSQRLSKD VFKSEYRDAY RGYSVAVGEF NGNPKDTEYV LGVPNWSTTL
GAVASYFGHT VAVTDINRDG KDDLLVGAPL FMEQRANRKL AEVGRVYVYL QLRTPHSLGN
PKHLTGTELY GRFGSAIAPL GDLDQDGYND IAIGAPFGGP NGRGRVFIFQ GQDEGLSPRP
SQVLDSPFHQ GPGFGFALKG ATDIDANGYP DLLVGAFGAN QVAIYRAQPV VWATVRLLVP
EVLNPTVKNC TLSNPKTTVA VSCFKIQMCM SITGHSIPEK LRINAELQLD RMKPRQGRRV
LLLGSQQSGT TLDLELSSGH VPFCHDTEAF LRDEAEFRDK LSPIVISLNV SLKSKGTEGP
LPLILNGDTH VQEQTRIILD CGEDDLCVPQ LQLKANVEGS PLVIGADNVL KLQVDTSNEG
EGAYEAELAI HLPQGSHFMQ ALSDIKNFEK LLCIQKKENE SQLVLCELGN PMKKDAKIRV
LMLVSVGNLE EVGDSVSFML QIKSKNRQNP NSEVFLLEVP VRAKALVELF GNSFPATLVF
SPPPEETLRN KDPTTVNRNT HKMEDASKVE HAFELHNQGP GAVSGLQLWV GFPSRSESDD
LLYVLDIQDH GGLQCSVQPP PNPFNLKVGQ PTPAPSSTHA HPFQHERERR SAFIPEHLGP
SGQQEPILVN CDAWPCTWVE CKLKQMERGQ RAMLTISTML WMPGLLKRPL EQFVLQSKAW
FNVSGLPYDV PAESLPHGHV VVETKLLQVR LEETEIPTWW VVVGVIGGLL LLVLLILVMW
KVGFFKRNRP PLEEEEEEE
//
